Zehbe, Ingeborg - Lakehead University

研究领域

Human papillomavirus (HPV) concerns us all: worldwide, HPV is the most common sexually transmitted infection in men and women. In women it is most common between the ages of 20 and 30, but in men it is equally prevalent throughout life. There are low and high-risk HPV types. If a high-risk type persists more than one year in the host then the risk of developing certain types of cancer (e.g. head and neck, cervical, and anal cancer) can increase up to 100-fold. The research of my group focuses on reasons of viral persistence, non-invasive treatment options learning from the human body's own molecular systems and prevention of cancer. We use state of the art molecular & cell biology methods as well as high throughput data analyses in a patient-centered health approach.

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Strontium doped poly-ε-caprolactone composite scaffolds made by reactive foaming. Zehbe R, Zehbe K. Mater Sci Eng C Mater Biol Appl. 2016 Oct 1;67:259-66. doi: 10.1016/j.msec.2016.05.045. The human papillomavirus 16 European-T350G E6 variant can immortalize but not transform keratinocytes in the absence of E7. Togtema M, Jackson R, Richard C, Niccoli S, Zehbe I. Virology. 2015 Nov;485:274-82. doi: 10.1016/j.virol.2015.07.025. Lopinavir up-regulates expression of the antiviral protein ribonuclease L in human papillomavirus-positive cervical carcinoma cells. Batman G, Oliver AW, Zehbe I, Richard C, Hampson L, Hampson IN. Antivir Ther. 2011;16(4):515-25. doi: 10.3851/IMP1786. Expression of integrins and Toll-like receptors in cervical cancer: effect of infectious agents. Werner J, Decarlo CA, Escott N, Zehbe I, Ulanova M. Innate Immun. 2012 Feb;18(1):55-69. doi: 10.1177/1753425910392934. Stability of prostaglandin E(2) (PGE (2)) embedded in poly-D,L: -lactide-co-glycolide microspheres: a pre-conditioning approach for tissue engineering applications. Watzer B, Zehbe R, Halstenberg S, James Kirkpatrick C, Brochhausen C. J Mater Sci Mater Med. 2009 Jun;20(6):1357-65. doi: 10.1007/s10856-008-3678-9. Immobilization and controlled release of prostaglandin E2 from poly-L-lactide-co-glycolide microspheres. Brochhausen C, Zehbe R, Watzer B, Halstenberg S, Gabler F, Schubert H, Kirkpatrick CJ. J Biomed Mater Res A. 2009 Nov;91(2):454-62. doi: 10.1002/jbm.a.32215. Inverse inkjet printed gold micro electrodes for the structured deposition of epithelial cells and fibrin. Zehbe R, Gross U, Schubert H. Biomol Eng. 2007 Nov;24(5):537-42.