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Novel ligands balance estrogen receptor β and α agonism for safe and effective suppression of the vasomotor response in the ovariectomized female rat model of menopause. McGregor, Chelsea; Sau, Andrea; Ruddy, Samantha C.; Leung, Dan; Webb, Murray; Durst, Tony; Wright, James S.; Lagace, Diane; Pratt, M. A. Christine. Endocrinology (2014), 155(7), 2480-2491. Synthesis and receptor binding in trans-​CD ring-​fused A-​CD estrogens: Comparison with the cis-​fused isomers. Dabrota, Cristian; Asim, Muhammad; Choueiri, Christine; Gargaun, Ana; Korobkov, Ilia; Butt, Ammara; Carlson, Kathryn E.; Katzenellenbogen, John A.; Wright, James S.; Durst, Tony. Bioorganic & Medicinal Chemistry Letters (2014), 24(16), 3841-3844. Preferential Estrogen Receptor β Ligands Reduce Bcl-​2 Expression in Hormone-​Resistant Breast Cancer Cells to Increase Autophagy. Ruddy, Samantha C.; Lau, Rosanna; Cabrita, Miguel A.; McGregor, Chelsea; McKay, Bruce C.; Murphy, Leigh C.; Wright, James S.; Durst, Tony; Pratt, M. A. Christine. Molecular Cancer Therapeutics (2014), 13(7), 1882-1893. Experimental versus predicted affinities for ligand binding to estrogen receptor: iterative selection and rescoring of docked poses systematically improves the correlation. Wright, James S.; Anderson, James M.; Shadnia, Hooman; Durst, Tony; Katzenellenbogen, John A. Journal of Computer-Aided Molecular Design (2013), 27(8), 707-721. Family of Diazapentalene Chromophores and Narrow-​Band-​Gap Polymers: Synthesis, Halochromism, Halofluorism, and Visible-​Near Infrared Photodetectivity. Qian, Gang; Qi, Ji; Davey, James A.; Wright, James S.; Wang, Zhi Yuan. Chemistry of Materials (2012), 24(12), 2364-2372. A-​CD Estrogens. I. Substituent Effects, Hormone Potency, and Receptor Subtype Selectivity in a New Family of Flexible Estrogenic Compounds. Wright, James S.; Shadnia, Hooman; Anderson, James M.; Durst, Tony; Asim, Muhammad; El-Salfiti, Mohamed; Choueiri, Christine; Pratt, M. A. Christine; Ruddy, Samantha C.; Lau, Rosanna; et al. Journal of Medicinal Chemistry (2011), 54(2), 433-448. Development of small-​molecule ligands and inhibitors. Chepelev, Leonid L.; Chepelev, Nikolai L.; Shadnia, Hooman; Willmore, William G.; Wright, James S.; Dumontier, Michel. Protein Targeting with Small Molecules (2009), 115-147. Deconstructing estradiol: Removal of B-​ring generates compounds which are potent and subtype-​selective estrogen receptor agonists. [Erratum to document cited in CA150:423383]. Asim, Muhammad; El-Salfiti, Mohamed; Qian, Yiming; Choueiri, Christine; Salari, Samira; Cheng, James; Shadnia, Hooman; Bal, Manpartap; Christine Pratt, M. A.; Carlson, Kathryn E.; et al. Bioorganic & Medicinal Chemistry Letters (2010), 20(22), 6861-6862. Genotoxicity of endogenous estrogens. Wright, James S. Edited by O’Brien, Peter; Bruce, W. Robert. Endogenous Toxins (2010), 2, 859-879. Oxidative modification of citrate synthase by peroxyl radicals and protection with novel antioxidants. Chepelev, Nikolai L.; Bennitz, Joshua D.; Wright, James S.; Smith, Jeffrey C.; Willmore, William G. Journal of Enzyme Inhibition and Medicinal Chemistry (2009), 24(6), 1319-1331. Rational design, synthesis, and optical properties of film-​forming, near-​infrared absorbing, and fluorescent chromophores with multidonors and large heterocyclic acceptors. Luo, Min; Shadnia, Hooman; Qian, Gang; Du, Xiaobo; Yu, Dengbin; Ma, Dongge; Wright, James S.; Wang, Zhi Yuan. Chemistry – A European Journal (2009), 15(35), 8902-8908, Preparation of estrogenic compounds for pharmaceutical use. Wright, James S.; Asim, Muhammad; Shadnia, Hooman; Durst, Tony. Can. Pat. Appl. (2009), CA 2653189 A1 20090804 Investigation of residues Lys112, Glu136, His138, Gly247, Tyr248, and Asp249 in the active site of yeast cystathionine β-​synthase. Lodha, Pratik H.; Shadnia, Hooman; Woodhouse, Colleen M.; Wright, James S.; Aitken, Susan M. Biochemistry and Cell Biology (2009), 87(3), 531-540. Stability of carbon-​centered radicals: effect of functional groups on the energetics of addition of molecular oxygen. Wright, James S.; Shadnia, Hooman; Chepelev, Leonid L. Journal of Computational Chemistry (2009), 30(7), 1016-1026. Using Molecular Strain and Aromaticity To Create Ultraweak C-​H Bonds and Stabilized Carbon-​Centered Radicals. Shadnia, Hooman; Wright, James S. Journal of Chemical Theory and Computation (2009), 5(4), 1129-1136. Deconstructing estradiol: Removal of B-​ring generates compounds which are potent and subtype-​selective estrogen receptor agonists. Asim, Mohammud; El-Salfiti, Mohamed; Qian, Yiming; Choueiri, Christine; Salari, Samira; Cheng, James; Shadnia, Hooman; Bal, Manpartap; Christine Pratt, M. A.; Carlson, Kathryn E.; et al. Bioorganic & Medicinal Chemistry Letters (2009), 19(4), 1250-1253. Interaction force diagrams: new insight into ligand-​receptor binding. Shadnia, Hooman; Wright, James S.; Anderson, James M. Journal of Computer-Aided Molecular Design (2009), 23(3), 185-194.