个人简介

Education B.S. Chemistry, Seoul National University, Korea, 1982 M.S. Chemistry, Seoul National University, Korea, 1984 Ph.D. Chemistry, Columbia University, USA, 1990 Research Experiences Postdoctoral Fellow, MIT, USA, 1991-1992

研究领域

ORG/MATER

Current Research Interests Hong"s group research involves the fields of molecular recognition and supramolecular chemistry. A major focus of the group is on the development of organic functional materials such as chemosensors and optoelectronic materials. They aim to develop optical and electrochemiluminescent sensors for biologically important molecules such as ions, amino acids, peptides, proteins, phosphates, pyrophosphates, carbohydrates, nucleotides and nucleic acids. Recently, they developed highly selective fluorescent sensors for various phophobiomolecules. Continuous works are directed at the bioanalytical applications such as an enzyme assay, a DNA/RNA sequencing technique, disease diagnosis and bioimaging. They are also involved in investigations on two-photon absorption (TPA) systems for sensing of signal molecules to ultimately address cellular processes involving biological ions and molecules in situ. They are investigating new methods for the construction of activity-based fluorescent probes that are useful for detecting specific proteins and enzymes that can be used as diagnostic or prognostic biomarkers in homogeneous solution. This area opens up new opportunities in a non-immunological diagnostic probe and its application to new drug development. Other important projects include the development of optoelectronic materials for organic light-emitting diodes (OLEDs), organic thin film transistors (OTFTs), dye-sensitized solar cells (DSSCs) and organic solar cells (OSCs). This project covers the molecular design of highly efficient organic and organometallic compounds, synthesis, photophysical studies, device fabrication and characterization. One of the specific research programs involves the development of functional supramolecuar nanostructures produced via self-assembly processes. They are particularly interested in the generation of nanosheet structures, nanofiber structures, organogels, and hydrogels. These supramolecules will be applied to the construction of advanced materials for optoelectronic and biological applications.

近期论文

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"Versatile RNA Interference Nanoplatform for Systemic Delivery of RNAs", Ki Young Choi, Oscar F. Silvestre, Xinglu Huang, Kyung Hyun Min, Gregory P. Howard, Naoki Hida, Albert J. Jin, Nicole Carvajal, Sang Wook Lee, Jong-In Hong, Xiaoyuan Chen. ACS Nano, 2014, 8 (5), 4559 - 4570. doi: 10.1021/nn500085k "Microfluidic Bead-based Sensing Platform for Monitoring Kinase Activity", Seung Hwan Lee, Hyun-Woo Rhee, Danny van Noort, Hong Jai Lee, Hee Ho Park, Ik-Soo Shin, Jong-In Hong, Tai Hyun Park. Biosensors and Bioelectronics, 2014, 57 (1), 1 - 9. doi: 10.1016/j.bios.2014.01.039 "A Nanoparticle Formula for Delivering siRNA or miRNAs to Tumor Cells in Cell Culture and in vivo", Ki Young Choi, Oscar F Silvestre, Xinglu Huang, Naoki Hida, Gang Liu, Don N Ho, Seulki Lee, Sang Wook Lee, Jong-In Hong, Xiaoyuan Chen. Nature Protocols , 2014, 9 (8), 1900 - 1915. doi: 10.1038/nprot.2014.128 "Phosphorescent Sensor for Phosphorylated Peptides Based on an Iridium Complex", Jung Hyun Kang, Hee Jin Kim, Tae-Hyuk Kwon, Jong-In Hong. Jo. Org. Chem., 2014, 79 (13), 6000 - 6005. doi: 10.1021/jo5005263 "Vacuum Processable Donor Material Based on Dithieno[3,2-b:2,3-d]thiophene and Pyrene for Efficient Organic Solar Cells", Jongchul Kwon, Tae-Min Kim, Hong-Se Oh, Jang-Joo Kim, Jong-In Hong. RSC Advances , 2014, 4 (47), 24453 - 24457. doi: 10.1039/C4RA02895C "Oligothiophene-modified Silver/silica Core-shell Nanoparticles for Inhibiting Open-circuit Voltage Drop and Aggregation in Polymer Solar Cells", Woochul Lee, Joohyun Lim, Jin-Kyu Lee, Jong-In Hong. J. Mater. Chem. A, 2014, 2 (37), 15357 - 15364. doi: 10.1039/C4TA02763A "Direct Exfoliation of Carbon Allotropes with Structural Analogues of Self-assembled Nanostructures and Their Photovoltaic Applications", Woochul Lee, Dong-Woo Lee, Myongsoo Lee, Jong-In Hong. Chem. Commun., 2014, 50 (94), 14851 - 14854. doi: 10.1039/C4CC05929H "Fluorescent Assay of Cyclic Nucleotide Phosphodiesterase Activity in a Neutral Aqueous Solution", So Jung Choi, Hyun-Woo Rhee, Jihye Kim, Doo Soo Chung, Jong-In Hong. Bull. Korean Chem. Soc., 2013, 34 (1), 31 - 32. doi: 10.5012/bkcs.2013.34.1.31 "Fluorescent Chemosensor for Biological Zinc Ions", Se Won Bae, Eunha Kim, Ik-Soo Shin, Seung Bum Park, Jong-In Hong. Supramolecular Chemistry, 2013, 25 (1), 2 - 6. doi: 10.1080/10610278.2012.720020 "Fluorescent Probes Designed for Detecting Human Serum Albumin on the Basis of Its Pseudo-esterase Activity", Sung-Jean Kim, Hyun-Woo Rhee, Hyun-Joo Park, Hye-Yeon Kim, Hyo-Soo Kim, Jong-In Hong. Bioorg. Med. Chem. Lett., 2013, 23 (7), 2093 - 2097. doi: 10.1016/j.bmcl.2013.01.124 "Discrimination of Redox-Responsible Biomolecules by a Single Molecular Sensor", Jinrok Oh, Jong-In Hong. Org. Lett., 2013, 15 (6), 1210 - 1213. doi: 10.1021/ol303403x "Two-Dimensional Sensor Array for Discrimination of Amines", Jung-Deog Lee, Jong-In Hong. Tet. Lett., 2013, 54 (22), 2890 - 2893. doi: 10.1016/j.tetlet.2013.03.118 "A Multifunctional Material Based on Triphenylamine and a Naphthyl Unit for Organic Light-Emitting Diodes, Organic Solar Cells, and Organic Thin-Film Transistors", Jongchul Kwon, Myoung Ki Kim, Jung-Pyo Hong, Woochul Lee, Seonghoon Lee, Jong-In Hong. Bull. Korean Chem. Soc., 2013, 34 (5), 1355 - 1360. doi: 10.5012/bkcs.2013.34.5.1355 "Real-time Monitoring of S-adenosyl-l-homocysteine Hydrolase Using a Chemodosimetric Fluorescence 'turn-on' sensor", Kyung-Sik Lee, Seung Hwan Lee, Jinrok Oh, Ik-Soo Shin, Tai Hyun Park, Jong-In Hong. Sensors and Actuators B: Chemical, 2013, 185 (1), 663 - 668. doi: 10.1016/j.snb.2013.05.045 "Efficient Deep-blue Emitters Based on Triphenylamine-linked Benzimidazole Derivatives for Nondoped Fluorescent Organic Light-emitting Diodes", Seongjin Jeong, Myoung-Ki Kim, Sung Hyun Kim, Jong-In Hong. Org. Electron., 2013, 14 (10), 2497 - 2504. doi: 10.1016/j.orgel.2013.06.022 "4,4-Di(pyren-1-yl)-1,1-biphenyl as an Efficient Material for Organic Light-Emitting Diodes and Thin-Film Transistors", Jongchul Kwon, Jung-Pyo Hong, Seonghoon Lee, Jong-In Hong. New J. Chem., 2013, 37 (9), 2881 - 2887. doi: 10.1039/C3NJ00295K "Focused Fluorescent Probe Library for Metal Cations and Biological Anions", Hyun-Woo Rhee, Sang Wook Lee, Jun-Seok Lee, Young-Tae Chang, Jong-In Hong. ACS Comb. Sci., 2013, 15 (9), 483 - 490. doi: 10.1021/co400034x "Metal-Free Organic Dyes with Benzothiadiazole as an Internal Acceptor for Dye-Sensitized Solar Cells", Woochul Lee, Ji yeon Seng, Jong-In Hong. Tetrahedron, 2013, 69 (44), 9175 - 9182. doi: 10.1016/j.tet.2013.08.075 "Ratiometric Fluorescent Probes for Hydrogen Peroxide from a Focused Library", Sang Wook Lee, Hyun-Woo Rhee, Young-Tae Chang, Jong-In Hong. Chem. Eur. J., 2013, 19 (44), 14791 - 14794. doi: 10.1002/chem.201302523