Yan, Tony (Hongbin) - Brock University - Department of Chemistry

研究领域

Natural and modified nucleic acids (light-responsive nucleic acids, glycosylated nucleic acids, sequence specific modification of nucleic acids); mucosal vaccine adjuvant development; colorimetric and fluorescent labeling of nucleic acids; DNA damage in bacterial spores. Undergraduate students interested in completing their CHEM/BTEC/BCHM 4F90/4F91 research projects in my lab are welcome to contact me. Undergraduate students interested in an NSERC USRA summer research award are also welcome to contact me.

近期论文

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Impact of selected flavonoids on bacterial biofilm formation is dependent on solid surfaces, manuscript under preparation. A novel colorimetric probe for dual sensing of Hg2+ and Cu2+ ions in water. 2017, submitted. Mazinani, S. A.; Yan, H.* Escherichia coli DE3 growth is slowed by microwave irradiation at constant bulk temperature, 2017, manuscript under revision. Yang, L.; Drew, B.; Yalagala, R.; Chaviwala, R.; Simionescu, R.; Lough, A.;* Yan, H.* Solvent-dependent behaviours of 3-amino-1,6-diethyl-4,4-diphenyl-2,5,7-trimethyl-1,5,7,8-tetramethyl-2,6-diethyl-4-bora-3a,4a-diaza-s-indacene, Acta Crystallogr. E. 2017, E73, 378. Yan, H.;* Powers, R.; Gibbons, A.; Joshi, D. Z-DNA–chemistry and biology, 2017, in press (invited). Yang, L.; Liao, D.-J.; Wu, A.-W.;* Yan, H.* Synthesis and fluorescent properties of aza-crown ether tethered BODIPY fluorophores, Tetrahedron Lett. 2017, 58, 889. Qiu, H.; Li, Z.; KuoLee, R.; Harris, G.; Gao, X.; Yan, H.; Xu, H.; Chen, W.* Host resistance to intranasal Acinetobacter baumannii reinfection in mice, Pathog. Dis. 2016, 74, pii: ftw048. doi: 10.1093/femspd/ftw048. Mazinani, S. A.; Yan, H.* Impact of microwave irradiation on enzymatic activity at constant bulk temperature is enzyme-dependent, Tetrahedron Lett. 2016, 57, 1589. Yalagala, R.; Mazinani, S. A.; Maddalena, L. A.; Stuart, J. A.; Yan, F.; Yan, H.* Microwave assisted synthesis of BODIPY-sugar conjugates through the Click chemistry and assembly of the conjugate into bilayers. Carbohydrate Res. 2016, 424, 15. Eljabu, F.; Dhruval, J.; Yan, H.* Incorporation of cyclic azobenzene into oligodeoxynucleotides for the photo-regulation of DNA hybridization. Bioorg. Med. Chem. Lett. 2015, 25, 5594. Mazinani, S. A.; DeLong B.; Yan, H.* Microwave radiation accelerates trypsin-catalyzed peptide hydrolysis. Tetrahedron Lett. 2015, 56, 5804. Yan, H.;* Yalagala, R.; Yan, F. Fluorescently labelled glycans and their applications, Glycoconjug. J. 2015, 32, 559. Kuolee, R.; Harris, G.; Yan, H.; Xu, H. H.; Conlan, W. J.; Patel, G. B.; Chen, W.* Intranasal immunization protects against Acinetobacter baumannii-associated pneumonia in mice, Vaccine 2015, 33, 260. Bordeleau, E.; Oberc, C.; Ameen, E.; Mendes da Silva, A.; Yan, H.* Identification of cytidine 2’,3’-cyclic monophosphate and uridine 2’,3’-cyclic monophosphate in Pseudomonas fluorescens pfo-1 culture. Bioorg. Med. Chem. Lett. 2014,24, 4520. Yang, L.; Yalagala, R. S.; Hutton, S.; Lough, A. J.; Yan, H.* Reactions of BODIPY with nitrates, Synlett 2014, 25, 2661. Yalagala, R. S.; Yan, H.* Reactions of alkynes with trisubstituted (Z)-bromoalkenyl-pinacolboronates towards the synthesis of 1,2,4,6-tetrasubstituted benzenes. Tetrahedron Lett. 2014, 55, 4830. Yalagala, R. S.; Zhou, N.; Yan, H.* Palladium(II)–copper(I) mediated homotrimerization and homotetramerization of terminal alkynes, Tetrahedron Lett. 2014, 55, 1883. Yang, L.; Li, J.; Simionescu, R.; Yan, H*. Observation of two N2-isobutyrylguanine tautomers by NMR spectroscopy, Magn. Reson. Chem. 2013, 51, 60–64. Dhruval, J.; Mitchell, M.; Bruce, D.; Lough, A.; Yan, H.* Synthesis of cyclic azobenzene analogues, Tetrahedron, 2012, 68, 8670. Zhou, N.; Wang, Q.; Lough, A.; Yan, H.* Preparation of (Z)-1,2-dichloroalkenes from terminal alkynes, Can. J. Chem. 2012, 90, 625. Yang, L.; Yan, H.* A Mannich-type reaction at the meso-methyl position of the BODIPY fluorophore, Synlett. 2012, 23, 1526. Cheng, H-J; Yan, H.; Sun, Y-L; Lu, C-Y; Huang, T-Y; Chen, S-J; Hu, C-H; Wu, Y-Y; Wu, A-T.* A simple and highly selective receptor for iodide in aqueous solution, Analyst 2012, 137, 571. Yang, L.; Simionescu, R.; Lough, A.; Yan, H.* Some observations relating to the stability of the BODIPY fluorophore under acidic and basic conditions, Dyes Pigments 2011, 91, 264. Zhao L, KuoLee R, Harris G, Tram K, Yan H, Chen W.* c-di-GMP protects against intranasal Acinetobacter baumannii infection in mice by chemokine induction and enhanced neutrophil recruitment, Int. Immunopharmacol. 2011, 11, 1378. Tram, K.; Sangvi, Y.; Yan, H.* Further studies on the detritylation in solid phase oligodeoxyribonucleotide synthesis, Nucleoside, Nucleotides & Nucleic Acids. 2011, 30, 12.