Atkinson, Jeffrey - Brock University - Department of Chemistry

研究领域

Organic Chemistry; Vitamin E Biochemistry; Lipid transfer proteins

近期论文

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Mikel Ghelfi, Lynn Ulatowski, Danny Manor, and Jeffrey Atkinson. Synthesis and characterization of a fluorescent probe for α-tocopherol suitable for fluorescence microscopy. Submitted to Bioorganic & Medicinal Chemistry, 2105 Xiaoling Leng, Jacob J. Kinnun, Drew Marquardt, Mikel Ghefli, Norbert Kučerka, John Katsaras, Jeffrey Atkinson, Thad A. Harroun, Scott E. Feller and Stephen R. Wassall. Tocopherol is well-designed to protect polyunsaturated phospholipids: md simulations Submitted to Biophysical Journal, 2015 Desiree Bailey; Jeffrey Atkinson; Solomon Fixon-Owoo; Martin C Henman; Graham G Shaw; Karen M Doyle, Brian P Kirby. Hydroxycinnamic acid amide derivatives of polyamines reverse spermine-induced CNS excitation. Pharmacology, Biochemistry and Behavior. [PubMed] 133:57-64, 2015 Baptist, M., Panagabko, C., Nickels, J. D., Katsaras, J., & Atkinson, J. 2,2′-Bis(monoacylglycero) PO4 (BMP), but not 3,1′-BMP, increases membrane curvature stress to enhance α-tocopherol transfer protein binding to membranes. Lipids. 50(3):323-8, 2015 [PubMed] Jianfei Jiang, Ahmet Bakan, Alexandr A Kapralov , Zhentai Huang, Andrew A Amoscato, Venkata K Garapati; Kulakulasooriyag I Ishara, Sunil K Saxena, Hülya Bayir, Jeffrey Atkinson, Ivet Bahar, Valerian E Kagan. Designing Inhibitors of Cytochrome c/Cardiolipin Peroxidase Complexes: Mitochondria-Targeted Imidazole-Substituted Fatty Acids. Free Rad. Biol. Med. 71, 221-230, 2014, [PubMed] Marquardt D, Williams JA, Kinnun JJ, Kučerka N, Atkinson J, Wassall SR, Katsaras J, Harroun TA. Dimyristoyl Phosphatidylcholine: A Remarkable Exception to α-Tocopherol's Membrane Presence. J. Am. Chem. Soc. 2014, 136(1): 203-10. [PubMed] Julie Goff, Donna Shields, Hong Wang, Erin Skoda, Melissa Sprachman, Peter Wipf , Venkata Krishna Garapati, Jeffrey Atkinson, Barry London, John Lazo, Valerian Kagan, Michael Epperly and Joel S. Greenberger. Evaluation of ionizing irradiation protectors and mitigators using clonogenic survival of human umbilical cord blood hematopoietic progenitor cells. (In Press: Experimental Hematology, 41(11):957-66 2013, 41(11):957-66. [PubMed] Marquardt, Drew; Williams, Justin; Kucerka, Norbert; Atkinson, Jeffrey; Wassall, Stephen; Katsaras, John; Harroun, Thad "Tocopherol activity correlates with its location in a membrane: A new perspective on the anti-oxidant Vitamin E." J. Am. Chem. Soc., 2013, 135 (20), pp 7523–7533.[PubMed] Bo Li, Jitendra R. Harjani, Nicholas S. Cormier, Hasam Madarati, Jeffrey Atkinson and Derek A. Pratt. Besting Vitamin E: The role of sidechain substitution on the reactivity of naphthyridinol antioxidants in lipid bilayers. J. Amer. Chem. Soc. 135, 1394–1405, 2013. [PubMed] Galen W Miller, Lynn Ulatowski, Edwin M Labut, Katie M Lebold, Danny Manor, Jeffrey Atkinson, Carrie L Barton, Robert L Tanguay, Maret G Traber. The α-tocopherol transfer protein is essential for vertebrate embryogenesis. PLoS ONE 7(10): e47402. doi:10.1371/journal.pone.0047402. 2013 [PubMed] Christine A. McCary, Youngdae Yoon, Candace Panagabko, Wonhwa Cho, Jeffrey Atkinson, and Joan M. Cook-Mills. Vitamin E isoforms directly bind PKCα and differentially regulate activation of PKCα. Biochemical Journal, 2012, 441, 189-198 [PubMed] Ulatowski, L., Parker, R., Davidson, C., Yanjanin, N., Kelley, T. J., Corey, D., Atkinson, J., Porter, F., Arai, H., Walkley, S. U., and D. Manor. Altered vitamin E status in Niemann-Pick type C disease. J. Lipid. Res., 2011,52,1400–1410. [PubMed] Jeffrey Atkinson, Alexandr A. Kapralov, Naveena Yanamala, Linda Pierce, James Peterson, Yulia Y. Tyurina, Michael Epperly, Zhentai Huang, Jianfei Jiang, Akihiro Maeda, Weihong Feng, Karla Wasserlos, Natalia A. Belikova, Vladimir A. Tyurin, Jackie Fletcher, Yongsheng Wang, Judith Klein-Seetharaman, Detcho A. Stoyanovsky, Hülya Bayîr, Bruce R. Pitt, Joel S. Greenberger, Valerian E. Kagan. A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death. Nature Communications 2, 2011, Article number: 497 (doi:10.1038/ncomms1499). [PubMed] Nishio, K., Ishida, N., Saito, Y., Ogawa-Akazawa, Y., Shichiri, M., Yoshida, Y., Hagihara, Y., Noguchi, N., Chirico, J., Atkinson, J., and Etsuo Niki. α-Tocopheryl phosphate: uptake, hydrolysis, and antioxidant action in cultured cells and mouse Free Radical Biology and Medicine, 2011, 50(12), 1794–1800. [PubMed] Wen Xiao Zhang, Varsha Thakur, Andrei Lomize, Irina Pogozheva, Candace Panagabko, Matt Cecchini, Matilda Baptist, Samantha Morley, Danny Manor and Jeffrey Atkinson. The Contribution of Surface Residues to Membrane Binding and Ligand Transfer by the α-Tocopherol Transfer Protein (α-TTP). J. Mol. Biol. 2010, 405, 972-988. [PubMed] Samantha Morley, Varsha Thakur, David Danielpour, Robert Parker, Hiroyuki Arai, Jeffrey Atkinson, Jill Barnholtz-Sloan, Eric Klein, and Danny Manor. The tocopherol transfer protein sensitizes prostate cancer cells to vitamin E. J. Biol. Chem. 2010, 285(46), 35578-35589. [PubMed] Ryan West, Candace Panagabko, and Jeffrey Atkinson. Synthesis and Characterization of BODIPY-α-Tocopherol: A Fluorescent Form of Vitamin E. J. Org. Chem. 2010, 75(9), 2883–2892. [PubMed] Yongsheng Wang, Candace Panagabko, Jeffrey Atkinson. Synthesis of α-tocohexaenol (α-T6) a fluorescent, oxidatively sensitive polyene analogue of α-tocopherol. Bioorganic & Medicinal Chemistry. 2010 18, 777–786. [PubMed] (Invited Review) Jeffrey Atkinson, Thad Harroun, Stephen R. Wassall, William Stillwell and John Katsaras. The location and behavior of α-tocopherol in membranes. Mol. Nutr. Food Res. 2010, 54, 1–11. [PubMed] Wen Xiao Zhang, Grant Frahm, Samantha Morley, Danny Manor and Jeffrey Atkinson. Effect of Bilayer Phospholipid Composition and Curvature on Ligand Transfer by the α-Tocopherol Transfer Protein. Lipids 2009 (in press)