个人简介

Education Ph.D. Chemistry, University of Cambridge, 2001 B.Sc. (1st class Hon) Chemistry, University of Auckland, 1998 Research Experiences Principal Investigator, Agency for Science, Technology and Research, Singapore, 2005-2011 Senior Research Chemist, Merck Research Laboratory, Rahway, USA, 2003-2005 Research Associate, Scripps Research Institute, La Jolla, USA, 2002-2003 Research Assistant, Auckland Cancer Society Research Center, New Zealand, 1998

研究领域

ORG

urrent Research Interests Total synthesis, a research field that renders the preparation of larger molecular constructs from their structurally simplified progenitor(s) through a series of carefully coordinated synthetic operations, has admirably served the scientific community through its contributions in both fundamental chemical research and in a wide-spectrum of physical and biological applications. Our research activity rests its foundation on complexity-inspired total synthesis, with strong emphasis on the design and orchestration of innovative synthetic strategies by employing modern synthetic technologies based on transition-metal and organo-catalysis. Convergent and yet flexible approach are pursued in order to maximize overall synthetic efficiency, and enable the preparation of rationally designed analogues for chemical-biology investigations. Novel reactivities bestowed by complex molecular architectures are explored in a methodological manner and further applied in the context of target-oriented synthesis.

近期论文

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Synthesis of the C18-Norditerpenoid Alkaloid Neofinaconitine: A Lesson in Convergent Synthesis Planning. Xiao-Yu Liu, David Yu-Kai Chen, Angewandte Chemie-International Edition 53(4), pp.924-926 (2014) Transition-metal and Organocatalysis in Natural Product Synthesis. David Yu-Kai Chen, Dawei Ma, Beilstein Journal of Organic Chemistry 9(1), pp.1192-1193 (2013) A Mast Cell Degranulation Screening Assay for the Identification of Novel Mast Cell Activating Agents. Herman F. Staats, Shaun M. Kirwan, Hae Woong Choi, Christopher P. Shelburne, Soman N. Abraham, Gulice Y. C. Leung, David Yu-Kai Chen, MedChemComm 4(1), pp.88-94 (2013) A Case Study of Single-Pill Combination Therapy: The Ezetimibe/Simvastatin Combination for Treatment of Hyperlipidemia. Xianhai Huang, David Yu-Kai Chen, ChemMedChem 7(11), pp.1882-1894 (2012) C-H Activation: A Complementary Tool in the Total Synthesis of Complex Natural Products. David Yu-Kai Chen, So Won Youn, Chemistry-A European Journal 18(31), pp.9452-9474 (2012) Recent Advances in the Total Synthesis of Cyclopropane-containing Natural Products. David Yu-Kai Chen, Rebecca H. Pouwer, Jean-Alexandre Richard, Chemical Society Reviews 41(13), pp.4631-4642 (2012) The Chemistry of the Polycyclic Polyprenylated Acylphloroglucinols. Jean-Alexandre Richard, Rebecca H. Pouwer, David Yu-Kai Chen, Angewandte Chemie-International Edition 51(19), pp.4536-4561 (2012) Chemical Synthesis of the Englerins. Rebecca H. Pouwer, Jean-Alexandre Richard, Chih-Chung Tseng, David Yu-Kai Chen, Chemistry-An Asian Journal 7(1), pp.22-35 (2012) A Chiral-Pool-Based Approach to the Core Structure of (+)-Hyperforin. Jean-Alexandre Richard, David Yu-Kai Chen, European Journal of Organic Chemistry 2012(3), pp.484-487 (2012) Lagunamide C, a Cytotoxic Cyclodepsipeptide from the Marine Cyanobacterium Lyngbya Majuscula. Ashootosh Tripathi, Jonathan Puddick, Michele R. Prinsep, Matthias Rottmann, Kok Ping Chan, David Yu-Kai Chen, Lik Tong Tan, Phytochemistry 72(18), pp.2369-2375 (2011) Total Synthesis of Echinopines A and B: Exploiting a Bioinspired Late-Stage Intramolecular Cyclopropanation. Philippe A. Peixoto, Jean-Alexandre Richard, Rene Severin, David Yu-Kai Chen, Organic Letters 13(21), pp.5724-5727 (2011) Adventures in Total Synthesis: A Personal Account. David Yu-Kai Chen, Synlett 22(17), pp.2459-2481 (2011) A Modular Synthesis of Salvileucalin B Structural Domains. Chih-Chung Tseng, Hanfeng Ding, Ang Li, Yucui Guan, David Yu-Kai Chen, Organic Letters 13(16), pp.4410-4413 (2011) Proteomic Signature of Fatty Acid Biosynthesis Inhibition Available for In Vivo Mechanism-of-Action Studies. Michaela Wenzel, Malay Patra, Dirk Albrecht, David Yu-Kai Chen, K. C. Nicolaou, Nils Metzler-Nolte, Julia E. Bandow, Antimicrobial Agents and Chemotherapy 55(6), pp.2590-2596 (2011) Synthesis of an Advanced Maoecrystal V Core Structure. Lin Dong, Lujiang Deng, Yee Hwee Lim, Gulice Y. C. Leung, David Yu-Kai Chen, Chemistry-A European Journal 17(21), pp.5778-5781 (2011) Synthesis of ent-Nanolobatolide. Hau Man Cheng, Weiwei Tian, Philippe A. Peixoto, Bhartesh Dhudshia, David Yu-Kai Chen, Angewandte Chemie-International Edition 50(18), pp.4165-4168 (2011) Formal Asymmetric Synthesis of Echinopine A and B. Philippe A. Peixoto, Rene Severin, Chih-Chung Tseng, David Yu-Kai Chen, Angewandte Chemie-International Edition 50(13), pp.3013-3016 (2011) Chemical Synthesis and Biological Evaluation of the Englerin Analogues. Kok Ping Chan, David Yu-Kai Chen, ChemMedChem 6(3), pp.420-423 (2011) A Second-Generation Formal Synthesis of (+)-Haplophytine. Weiwei Tian, Lohitha Rao Chennamaneni, Takahiro Suzuki, David Yu-Kai Chen, European Journal of Organic Chemistry 2011(6), pp.1027-1031 (2011) Formal Syntheses of (-)- and (+)-Phalarine. Hanfeng Ding, David Yu-Kai Chen, Angewandte Chemie-International Edition 50(3), pp.676-679 (2011)