Després, Charles - Brock University - Department of Biological Sciences

研究领域

The Després lab’s basic research interests are focused on understanding the signal transduction pathway and the biochemical mechanisms by which NPR1 regulates gene expression in the model system Arabidopsis. Given that the salicylic acid-receptor, NPR1, interacts with transition metals, the lab has also an interest in metal chemistry as it relates to proteins. The lab employs a multidisciplinary approach using molecular, biochemical, biophysical, genomic, and chemical tools to reach its objectives.

近期论文

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Wu Y., Zhang D., Chu J.Y., Boyle P., Wang Y., Brindle I. D., De Luca V., Després, C. (2012). The Arabidopsis NPR1 protein is a receptor for the plant defense hormone salicylic acid. Cell Reports 1: 639-647. Boyle P., Le S.E., Rochon A., Shearer H.L., Murmu J., Chu J.Y., Fobert P.R., Després C. (2009). The BTB/POZ domain of the Arabidopsis disease resistance protein NPR1 interacts with the repression domain of TGA2 to negate its function. Plant Cell 21: 3700-3713. González-Lamothe, R., Boyle P., Dulude, A., Roy, V., Lezin-Doumbou, C., Kaur, G.S., Bouarab, K., Després, C., Brisson, N. (2008). The transcriptional activator Pti4 is required for the recruitment of a repressosome nucleated by repressor SEBF at the potato PR-10a gene. Plant Cell 20: 3136-3147. Rochon, A., Boyle, P., Wignes, T., Fobert, P.R., Després, C. (2006). The co-activator function of the Arabidopsis NPR1 requires the core of its BTB/POZ and the oxidation of C-terminal cysteines. Plant Cell 18: 3670–3685. Shearer H.L., Cheng Y.T., Wang L., Liu J., Boyle P., Després, C., Zhang Y., Li X., and Fobert, P.R. (2012). Arabidopsis Clade I TGA Transcription Factors Regulate Plant Defenses in an NPR1-Independent Fashion. Mol. Plant Microbe Interact. 25:1459-1468. Boyle P. and Després, C. (2010). Dual-function transcription factors and their entourage. Unique and unifying themes governing two pathogenesis-related genes. Plant Signaling and Behavior. 6: 629-634. Cheng, Y.T., Germain, H., Wiermer, M., Bi, D., Xu, F., Garcia, A.V., Wirthmueller, L., Després, C., Parker, J.E., Zhang, Y., and Li, X. (2009). Nuclear pore complex component MOS7/Nup88 is required for innate immunity and nuclear accumulation of defense regulators in Arabidopsis. Plant Cell 21: 2503-2516. Shearer, H.L., Wang, L., DeLong, C., Després, C., and Pierre R. Fobert (2009). NPR1 enhances the DNA binding activity of the Arabidopsis bZIP transcription factor TGA7. Botany 87: 561-570. Boyle P., Fobert, P.R., and Després, C. (2009). Disease Resistance in Arabidopsis, Starring TGA2 and also Featuring NPR1. Chapter 4 In: Molecular Plant Microbe-Interaction. Bouarab K, Brisson N, Daayf, F (Eds). CABI, Cambridge, MA.: 75-93. Després, C. and Fobert, P.R. (2006). In vivo biochemical characterization of transcription factors regulating plant defense response to disease. Can. J. Plant Pathol. 28: 3-15. Fobert, P.R. and Després, C. (2005). Redox control of systemic acquired resistance. Curr. Opin. Plant Biol. 8: 378-382. Desveaux, D., Subramaniam, R., Després, C., Mess, J.-N., Lévesque, C., Fobert, P., Dangl, J., and Brisson, N. (2004). A “Whirly” transcription factor is required for salicylic acid-dependent disease resistance in Arabidopsis. Developmental Cell 6: 229-240. Després, C., Chuback, C., Rochon, A., Clark, R., Bethune, T., Desveaux, D., and Fobert, P.R. (2003). The Arabidopsis NPR1 disease resistance protein is a novel cofactor that confers redox regulation of DNA binding activity to the basic domain/leucine zipper transcription factor TGA1. The Plant Cell 15: 2181-2191. Chakravarthy, S., Tuori, R.P., D’Ascenzo, M.D., Fobert, P.R., Després, C., and Martin,G.B. (2003). The tomato transcription factor Pti4 regulates defense-related gene expression via GCC box- and non-GCC box cis elements. The Plant Cell15: 3033-3050. Desveaux, D., Després, C., Joyeux, A., Subramaniam, R., and Brisson, N. (2000). PBF-2 is a novel single-stranded DNA binding factor implicated in PR-10a gene activation in potato. The Plant Cell 12: 1477-1489. Després, C., DeLong, C., Glaze, S., Liu, E., and Fobert, P.R. (2000). The Arabidopsis NPR1/NIM1 enhances the DNA binding activity of a subgroup of the TGA family of bZIP transcription factors. The Plant Cell 12: 279-290. Subramaniam, R., Després, C., and Brisson, N. (1997). A functional homolog of mammalian protein kinase C participates in the elicitor-induced defense response in potato. The Plant Cell 9: 653-664. Després, C., Subramaniam, R., Matton, D., and Brisson, N. (1995). The activation of the potato PR-10a gene requires the phosphorylation of the nuclear factor PBF-1. The Plant Cell 7: 589-598. Després, C., Saba El Leil, M., Rivard, S., Morse, D., and Cappadocia, M. (1994). Molecular cloning of two Solanum chacoense S-alleles and a hypothesis concerning their evolution. Sex. Plant. Reprod. 7: 169-176.