PELKA, Peter - University of Manitoba - Department of Microbiology

个人简介

PhD Biochemistry and Biomedical Sciences Sept. '02--Oct. '06 -- McMaster University, Hamilton, ON Advisor: Dr. Peter F. Whyte MSc Biology Sept. '98-‐Nov. '00 ‐ McMaster University, Hamilton, ON Advisor: Dr. Ana R. Campos BSc Molecular Biology, Biotechnology and Genetic Engineering Sept. '94‐June '98 -‐ McMaster University, Hamilton, ON Post--‐doctoral training: Jan. 2011--‐May 2012 – Post--‐doctoral fellow, McMaster University, Institute for Infectious Disease Research Supervisor: Dr. Dawn Bowdish, Assistant Professor, Dept. of Pathology & Molecular Medicine Sept. 2006--‐Aug. 2010 – Post--‐doctoral fellow, University of Western Ontario, Department of Oncology Supervisor: Dr. Joseph S. Mymryk, Professor Dept. of Microbiology and Immunology Academic appointments: July '12‐Present–Assistant Professor, University of Manitoba, Department of Microbiology

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Olanubi O, Frost JR, Radko R, Pelka P “ Suppresion of Type I interferon response by E1A via RuvBL1/Pontin.” J Virol, 2017. In press. Frost JR, Olanubi O, Cheng, SKH, Soriano A, Crisostomo L, Lopez A, Pelka P “The interaction of adenovirus E1A with the mammalian protein Ku70/XRCC6”. Virology 500:11-21, 2017. Novakowski KE, Han S, Dorrington MG, Hyunh A, Pelka P, Whyte P, Guarné A, Sakamoto K, Bowdish DME. “Naturally Occurring Transcript Variants of MARCO Reveal the SRCR Domain is Critical for Ligand Binding & Uptake.” Immunology & Cell Biology 94(7):646-55, 2016. Jung R, Radko S, Pelka P “The dual nature of Nek9 in adenovirus replication.” J Virol, 90(4): 1931-43, 2016. *Selected for cover of the Journal and chosen by the editors as a Spotlight article due to novelty and scientific merit. Radko S, Jung R, Olanubi O, Pelka P “Effects of adenovirus type 5 E1A isoforms on viral replication in arrested human cells.” PLOS One 10:e0140124, 2015. Radko S#, Koleva M#, James K, Jung R#, Mymryk JS, Pelka P “Adenovirus E1A targets the DREF nuclear factor to regulate virus gene expression, DNA replication and growth.” J Virol, 88(22): 13469-81, 2014. #My trainees. Arulsundaram VD, Webb P, Yousef AF, Pelka P, Fonseca GJ, Baxter JD, Walfish PG, Mymryk JS. “The adenovirus 55 residue E1A protein is a transcriptional activator and binds the unliganded thyroid hormone receptor.” J Gen Virol 95(1): 142-52, 2014. Cohen MJ, Yousef AF, Massimi P, Fonseca GJ, Todorovic B, Pelka P, Turnell AS, Banks L, Mymryk JS. “Dissection of the C-terminal region of E1A re-defines the roles of CtBP and other cellular targets in oncogenic transformation.” J Virol 87: 10348-55, 2013. *Featured article. Ablack JA, Cohen M, Thillainadesan G, Fonseca GJ, Pelka P, Torchia J, Mymryk JS. “Cellular GCN5 is a Novel Regulator of Human Adenovirus E1A-Conserved Region 3 Transactivation.” J Virol 86:8198-209, 2012. Miller MS, Pelka P, Fonseca GJ, Cohen M, Kelly JN, Barr SD, Turnell AS, Grand RJ, Whyte P, Mymryk JS. “Characterization of the 55 residue E1A protein encoded by species C adenovirus.” J Virol 86:4222-33, 2012. Pelka P*, Miller MS, Cecchini M, Yousef AF, Bowdish DM, Dick F, Whyte P, Mymryk JS. “Adenovirus E1A directly targets the E2F/DP-1 complex.” J Virol 85: 8841-51, 2011. *Corresponding author. Ablack JNG, Pelka P, Yousef AF, Turnell AS, Grand RJ, Mymryk JS. “Comparison of E1A CR3 Dependent Transcriptional Activation Across Six Different Human Adenovirus Subgroups” J Virol 84:12771-81, 2010. Yousef AF, Pelka P*, Fonseca GJ*, Ablack JNG, Walsh C, Shaw GS, Bazett-Jones DP, Mymryk JS. “Identification of a molecular recognition feature in the E1A oncoprotein that confers binding to the SUMO conjugase Ubc9.” Oncogene 29:4693-704, 2010. *Shared authorship. Pelka P, Ablack JNG, Shuen M, Yousef AF, Rasti M, Grand RJ Turnell AS, Mymryk JS. “Identification of a second independent binding site for the pCAF acetyltransferase in adenovirus E1A.” Virology 391:90-8, 2009. Pelka P*, Ablack JNG, Torchia J, Turnell AS, Grand RJA, Mymryk JS. “Transcriptional control by adenovirus E1A conserved region 3 via p300/CBP.” Nucleic Acids Res 37: 1095-1106, 2009. *Corresponding author. Pelka P*, Bruton RK*, Mapp KL, Fonseca GJ, Torchia J, Turnell AS, Mymryk JS, Grand RJA. “Identification of a second CtBP binding site in adenovirus 5 E1A conserved region 3.” J Virol 82: 8476-86, 2008. *Shared authorship. Pelka P, Ablack JNG, Fonseca GJ, Yousef AF, Mymryk JS. “Intrinsic structural disorder in adenovirus E1A: a viral molecular hub linking multiple diverse processes.” J Virol 82:7252-63, 2008. Pelka P, Scimè A, Mandalfino C, Joch M, Abdulla P, Whyte P. “Adenovirus E1A proteins direct subcellular redistribution of Nek9, a NimA-related kinase.” J Cell Physiol 212:13-25, 2007. Howe JA, Pelka P, Antelman D, Wilson C, Cornell D, Hancock W, Ramachandra M, Avanzini J, Horn M, Wills K, Sutjipto S, Ralston R. “Matching complementing functions of transformed cells with stable expression of selected viral genes for production of E1-deleted adenovirus vectors.” Virology 345:220-30, 2006. DeSousa D, Mukhopadhyay M, Pelka P, Zhao X, Dey BK, Robert V, Pelisson A, Bucheton A, Campos AR. “A Novel Double-stranded RNA-binding Protein, Disco Interacting Protein 1 (DIP1), Contributes to Cell Fate Decisions during Drosophila Development.” JBC 278:38040-60, 2003. Mukhopadhyay M, Pelka P, DeSousa D, Kablar B, Schindler A, Rudnicki MA, Campos AR. “Cloning, genomic organization and expression pattern of a novel Drosophila gene, the disco-interacting protein 2 (dip2), and its murine homolog.” Gene 293:59-65, 2002. Lee KJ, Mukhopadhyay M, Pelka P, Campos AR, Steller H. “Autoregulation of the Drosophila disconnected gene in the developing visual system.” Dev Biol 214:385-98, 1999.