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Vadlamani G, Stubbs KA, Désiré J, Blériot Y, Vocadlo DJ, Mark BL. (2017) Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress β-lactam antibiotic resistance. Protein Science Mar 28. doi: 10.1002/pro.3166. [Epub ahead of print]PMID: 28370529 Muggenthaler MM, Chowdhury B, Hasan SN, Cross HE, Mark B, Harlalka GV, Patton MA, Ishida M, Behr ER, Sharma S, Zahka K, Faqeih E, Blakley B, Jackson M, Lees M, Dolinsky V, Cross L, Stanier P, Salter C, Baple EL, Alkuraya FS, Crosby AH, Triggs-Raine B, Chioza BA. (2017) Mutations in HYAL2, Encoding Hyaluronidase 2, Cause a Syndrome of Orofacial Clefting and Cor Triatriatum Sinister in Humans and Mice. PLoS Genet. 2017 Jan 12;13(1):e1006470.PMID: 28081210 Hamou-Segarra M, Zamorano L, Vadlamani G, Chu M, Sánchez-Diener I, Juan C, Blázquez J, Stubbs KA, Mark BL, Oliver A (2017) Synergistic activity of fosfomycin, β-lactams and peptidoglycan recycling inhibition against P.aeruginosa Journal of Antimicrobial Chemotherapy 72(2):448-454PMID: 28370529 Perley-Robertson GE, Yadav AK, Winogrodzki JL, Stubbs KA, Mark BL, Vocadlo DJ (2016) A Fluorescent Transport Assay Enables Studying AmpG Permeases Involved in Peptidoglycan Recycling and Antibiotic Resistance. ACS Chem Biol. 11(9):2626-35PMID: 27442597 Santana AG, Vadlamani G, Mark BL and Withers SG (2016) N-Acetyl glycals are tight-binding and environmentally insensitive inhibitors of hexosaminidases. Chem Commun (Camb). 52(51):7943-6PMID: 27253678 Osmon KJ, Woodley E, Thompson P, Ong K, Karumuthil-Melethil S, Keimel JG, Mark BL, Mahuran D, Gray S, Walia JS (2016) Systemic Gene Transfer of a Hexosaminidase Variant Using a scAAV9.47 Vector Corrects GM2 Gangliosidosis in Sandhoff Mice. Hum Gene Ther . 27(7):497-508PMID: 27199088 Karumuthil-Melethil S, Nagabhushan Kalburgi S, Thompson P, Tropak M, Kaytor MD, Keimel JG, Mark BL, Mahuran D, Walia JS, Gray SJ. (2016) NOVEL VECTOR DESIGN AND HEXOSAMINIDASE VARIANT ENABLING SELF-COMPLEMENTARY AAV FOR THE TREATMENT OF TAY-SACHS DISEASE. Hum Gene Ther. 27(7):509-21PMID: 27197548 Tropak MB, Yonekawa S, Karumuthil-Melethil S, Thompson P, Wakarchuk W, Gray SJ, Walia JS, Mark BL* and Mahuran D* (2016) Construction of a Hybrid β-Hexosaminidase Subunit Capable of Forming Stable Homodimers that Hydrolyze GM2 Ganglioside in vivo. Molecular Therapy - Methods & Clinical Development (Nature Publishing Group) 3:15057. doi: 10.1038/mtm.2015.57. eCollection 2016*corresponding authorsPMID: 26966698 Zaloba P, Bailey-Elkin BA, Derksen M and Mark BL (2016) Structural and biochemical insights into the peptidoglycan hydrolase domain of FlgJ from Salmonella typhimurium. PLoS One 11(2):e0149204.PMID: 26871950 Bacik JP, Klesmith JR, Whitehead TA, Jarboe LR, Unkefer CJ, Mark BL, Michalczyk R (2015) Producing Glucose 6-Phosphate from Cellulosic Biomass: Structural insights into levoglucosan bioconversion J Biol Chem. 290(44):26638-48PMID: 26354439 Vadlamani G, Thomas MD, Patel TR, Donald LJ, Reeve TM, Stetefeld J, Standing KG, Vocadlo DJ, Mark BL. (2015) The β-lactamase Gene Regulator AmpR is a Tetramer that Recognizes and Binds the D-Ala-D-Ala Motif of its Repressor UDP-MurNAc-pentapeptide. J Biol Chem. 290(5):2630-43PMID: 25480792 [PubMed - as supplied by publisher] Bailey-Elkin BA, Knaap RC, Johnson GG, Dalebout TJ, Ninaber DK, van Kasteren PB, Bredenbeek PJ, Snijder EJ, Kikkert M, Mark BL (2014) Crystal Structure of the MERS Coronavirus Papain-Like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate its Role in Innate Immune Suppression. J Biol Chem 289(50):34667-82.PMID: 25320088 [PubMed - - in process] Li Y, Treffers EE, Napthinee S, Tas A, Zhu L, Sun Z, Belle S, Mark BL, van Veelen PA, van Hemert MJ, Firth AE, Brierley I, Snijder EJ and Fang Y (2014) Trans-activation of programmed ribosomal frameshifting by a viral protein. Proc Natl Acad Sci U S A. 111(21):E2172-81.PMID: 24825891 [PubMed - indexed for MEDLINE] Bailey-Elkin BA, van Kasteren PB, Snijder EJ, Kikkert M and Mark BL (2014) Viral OTU Deubiquitinases: a Structural and Functional Comparison. PLoS Pathogens 10(3):e1003894.PMID: 24676359 [PubMed - in process] Bacik JP, Tavassoli M, Patel TR, McKenna SA, Vocadlo DJ, Khajehpour M and Mark BL (2014) Conformational itinerary of Pseudomonas aeruginosa 1,6-Anhydro-N-acetylmuramic acid kinase during its catalytic cycle. J Biol Chem. 289(7):4504-14PMID: 24362022 [PubMed - in process]