个人简介

Brown University, B.Sc., Neuroscience, 2004; Massachusetts Institute of Technology, Ph.D., Biological Engineering, 2008

研究领域

The Shapiro group develops molecular technologies for noninvasive imaging and control of cellular function, and uses these technologies to study basic biology and create cellular diagnostics and therapeutics. Many important biological processes occur deep inside living organisms. Their study requires technologies to image and manipulate cellular and molecular function non-invasively. To develop such technologies, we pursue fundamental advances at the interface of molecular and cellular engineering with various forms of energy: magnetic, mechanical, thermal and chemical. Our work takes advantage of naturally evolved biological structures with unique physical properties, which we use as starting points for engineering. Our key biophysical methods include magnetic resonance and ultrasound, and our primary biological interests are in neuroscience, microbiology and immunology.

Biochemistry and Molecular Biophysics; Chemical Engineering

近期论文

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Szablowski JO, Lue B, Lee-Gosselin A, Malounda D, Shapiro MG*. Acoustically targeted chemogenetics for noninvasive control of neural circuits. Submitted. bioRxiv pre-print Sato T*, Shapiro MG#*, Tsao DY#*. Ultrasonic neuromodulation causes widespread cortical activation via an indirect auditory mechanism. Submitted. bioRxiv pre-print | companion manuscript Davis HC#, Ramesh P#, Bhatnagar A, Lee-Gosselin A, Barry JF, Glenn DR, Walsworth RL, Shapiro MG*. Mapping the microscale origins of MRI contrast with subcellular NV diamond magnetometry. Nature Communications 9, 131 (2018). article Bourdeau RW, Lee-Gosselin A, Lakshmanan A, Farhadi A, Ravindra Kumar S, Nety SP, Shapiro MG*. Acoustic reporter genes for noninvasive imaging of microorganisms in mammalian hosts. Nature 553, 86–90 (2018). article | news and views | press Monge M, Lee-Gosselin A, Shapiro MG*, Emami A*. Localization of microscale devices in vivo using addressable transmitters operated as magnetic spins. Nature Biomedical Engineering 1, 736-744 (2017). article | news and views | press Lakshmanan A#, Lu GJ#, Farhadi A#, Nety SP#, Kunth M, Lee-Gosselin A, Maresca D, Bourdeau RW, Yin M, Yan J, Witte C, Malounda D, Foster FS, Schröder L, Shapiro MG*. Preparation of biogenic gas vesicle nanostructures for use as contrast agents for ultrasound and MRI. Nature Protocols 12, 2050-2080 (2017). article Piraner DI, Farhadi A, David HC, Wu D, Maresca D, Szablowski JO, Shapiro MG*. Going deeper: biomolecular tools for acoustic and magnetic imaging and control of cellular function. Biochemistry (2017). article Ojala DS, Sun S, Santiago-Ortiz JL, Shapiro MG, Romero PA, Schaffer DV*. In vivo selection of a computationally designed SCHEMA AAV library yields a novel variant for infection of adult neural stem cells in the SVZ. Molecular Therapy (2017). article Maley AM, Lu GJ, Shapiro MG, Corn RM*. Characterizing single polymeric and protein nanoparticles with surface plasmon resonance imaging measurements. ACS Nano (2017). article Mukherjee A, Davis HC, Ramesh P, Lu GJ, Shapiro MG*. Biomolecular MRI reporters: evolution of new mechanisms. Progress in NMR Spectroscopy (2017). article Le Floc’h J*, Zlitni A, Bilton HA, Yin M, Farhadi A, Janzen NR, Shapiro MG, Valliant JF*, Foster FS. In vivo biodistribution of radiolabeled acoustic protein nanostructures. Molecular Imaging and Biology 1-10 (2017). article Cherin E*, Melis JM, Bourdeau RW, Yin M, Kochmann DM, Foster FS#, Shapiro MG#. Acoustic behavior of Halobacterium salinarum gas vesicles in the high frequency range: experiments and modeling. Ultrasound in Medicine and Biology 43, 1016-1030 (2017). article Maresca D, Lakshmanan A, Lee-Gosselin A, Melis JM, Ni YL, Bourdeau RW, Kochmann DM, Shapiro MG*. Nonlinear ultrasound imaging of nanoscale acoustic biomolecules. Applied Physics Letters 110, 073704 (2017). article Gilad AA*, Shapiro MG*. Molecular Imaging in Synthetic Biology, and Synthetic Biology in Molecular Imaging. Molecular Imaging and Biology 19 (2017). article Piraner DI#, Abedi MH#, Moser BA, Lee-Gosselin A, Shapiro MG*. Tunable thermal bioswitches for in vivo control of microbial therapeutics. Nature Chemical Biology 13, 75-80 (2017). article | press | video | highlight in Nature Methods