Schweizer, Frank - University of Manitoba - Department of Medical Microbiology and Infectious Diseases

个人简介

Associate Professor Department of Chemistry and Assistant Professor Medical Microbiology, University of Manitoba Degrees: Ph.D. University of Alberta (1999), Dipl. Chem. Albert-Ludwigs University Freiburg , Germany (1993) Mailing Address: Department of Chemistry, 460 Parker Building, 144 Dysart Rd. Winnipeg , Manitoba R3T 2N2

研究领域

Development of novel antibiotics, antimicrobial peptidomimetics, aminoglycosides, glycobiology of infection, drug discovery and preclinical evaluation of antibacterial lead structures, protein folding, structural glycobiology, chemical biology of aging.

近期论文

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Zhanel, G.G., Schweizer, F., Karlowsky, J.A. Oritavancin: Mechanism of action. Clin. Infect. Diseases (in press 2012). Findlay, B., Zhanel, G.G.; Schweizer, F. Investigating the antimicrobial peptide “window of activity” using cationic lipopeptides with hydrocarbon and fluorinated tails. Int. J. Antimicrob. Agents (in press 2012) Zhanel, G.G., Lawson, C.D., Zelenitsky, A., Findlay, B., Schweizer, F., Adam, H., Walkty, A., Rubinstein, E., Gin, A.S., Hoban, D.J., Lynch, J.P., Karlowsky, J.A.. Comparison of the next generation aminoglycoside plazomicin (ACHN-490) to gentamicin, tobramycin, and amikacin. Exp. Rev. Antiinfect. Ther. (in press 2012). Findlay, B., Zhanel, G.G., Schweizer, F. Neomycin-phenolic conjugates: Polycationic amphiphiles with broad-spectrum antibacterial activity, low haemolytic activity and weak serum protein binding. Bioorg. Med. Chem. Lett. 22, 1499-1503 (2012). Naziga, E.B., Schweizer, F., Wetmore, S.D. Conformational study of the hydroxyproline-O-glycosidic linkage: Sugar-peptide orientation and prolyl amide isomerization in (a,b)-galactosylated 4(R/S)-hydroxyproline. J. Phys. Chem. B. 116, 860-871 (2012). Koizumi, A., Yamano, K., Schweizer, F., Takeda, T., Kiuchi, F., Hada, N. Synthesis of the carbohydrate moiety of the parasite Echinococcus multilocularis and their antigenicity against human sera. Eur. J. Med. Chem. 46, 1768-1778 (2011). Mondal, D., Zhanel, G.G., Schweizer, F. Synthesis and antibacterial properties of carbohydrate-templated lysine surfactants. Carbohydr. Res. 346, 588-594 (2011). Bera, S. Zhanel, G.G., Schweizer, F. Synthesis and antibacterial activity of amphiphilic lysine-ligated neomycin B conjugates. Carbohydr. Res. 346, 560-568 (2011). Fujita, Y., Ohshima, N., Hasegawa, A., Schweizer, F., Takeda, T., Kiuchi, F., Hada, N., Synthesis, inhibitory effects on nitric oxide and structure-activity relationships of a glycosphingolipid from the marine sponge Aplysinella rhax and its analogues. Molecules 16, 637-651 (2011). Zhanel, G.G., Decorby, M., Adam, H., Mulvey, M.R., McCracken, M., Lagacé-Wiens P., Nichol, K.A., Wierzbowski, A., Baudry P.J., Tailor, F., Larlowsky, J.A., Walkty, A., Schweizer, F., Johnson, J., Hoban D.J. Prevalence of antimicrobial-resistant pathogens in Canadian hospitals: results of the Canadian ward surveillance study (CANWARD 2008). Antimicrobial Agents Chemother. 54, 4684-4693 (2010). Teklebrhan R.B., Zhang, K., Schreckenbach, G., Schweizer, F., Wetmore, S.D. Intramolecular hydrogen-bond controlled prolyl amide isomerization in glucosyl 3(S)-hydroxy-5-hydroxymethylproline hybrids: a computational study. J. Phys Chem. B 114, 11594-11602 (2010). Findlay, B., Zhanel, G.G., Schweizer, F. Cationic amphiphiles: a new generation of antimicrobials inspired by the natural antimicrobial scaffold. Antimicrobial Agents Chemother. 54, 4049-4058 (2010). Kanaya T, Yagi, S., Schweizer, F., Takeda, T., Kiuchi, F., Hada, N. Synthetic studies on glycosphingolipids from protostomia phyla: synthesis of glycosphingolipids from the parasite Schistosoma mansoni. Chem. Pharm. Bull. (Tokyo) 58, 811-817, (2010). Mondal, D., Schweizer, F. Synthesis of allose-templated hydroxyornithine and hydroxyarginine analogues. Carbohydr. Res. 345, 1533-1540, (2010). Bera, S., Zhanel, G.G., Schweizer, F. Evaluation of amphiphilic aminoglycoside-peptide triazole conjugates as antibacterial agents. Bioorg. Med. Chem. Lett. 20, 3031-3035 (2010). Zhang, K., Schweizer, F. Influence of glucose-templated proline mimetics on the b-turn conformation of the peptide fragment Ac-Leu-D-Phe-Pro-Val-NMe2 found in Gramicidin S. Carbohydr. Res. 345, 1114-1122 (2010). Bera, S, Zhanel, G.G., Schweizer, F. Antibacterial activities of aminoglycoside antibiotics-derived cationic amphiphiles. Polyol-modified neomycin B-, kanamycin A-, amikacin- and neamine-based amphiphiles with potent broad-spectrum antibacterial activity. J. Med. Chem. 53, 3626-3631 (2010). Owens, N.W., Stetefeld, J., Lattová, E., Schweizer, F. Contiguous O-galactosylation of 4R-hydroxy-L-proline residues forms very stable polyproline II helices. J. Am. Chem. Soc. 132, 5036-5042 (2010). Bera, S. Zhanel, G.G., Schweizer, F. Antibacterial activity of guanidinylated neomycin B and kanamycin A-derived amphiphilic lipid conjugates. J. Antimicrob. Chemother. 65, 1224-1227 (2010). Zhanel, G.G., Calic, D., Schweizer, F., Zelenitsky, S., Adam, H., Lagace-Wiens, P.R.S., Rubinstein, E., Gin, A.S., Hoban, D.J., Karlowsky, J.A. Dalbavancin, oritavancin and televancin: A comparative review. Drugs 70, 859-886 (2010). Hada, N., Shida, Y., Negishi, N., Schweizer, F., Takeda, T. Synthesis of glycoclusters containing a phosphocholine residue related to a glycosphingolipid from the earthworm Pheretima hilgendorfi. Chem. Pharm. Bull. 57, 1081-1088 (2009). Schweizer, F. Cationic amphiphilic peptides with cancer-selective toxicity. Eur. J. Pharmcol. 625, 190-194 (2009). Owens, N. W., Lee, A., Marat, K., Schweizer, F. The implications of (2S,4S)-hydroxyproline 4-O-glycosylation for prolyl amide isomerization. Chem. Eur. J. 15, 10649-10657 (2009). Zhanel, G.G., DeCorby, M., Nichol, K.A., Wierzbowski, A., Baudry, P., Karlowsky, J.A.,Lagacé-Wiens, P., Walkty, A., Schweizer F., McCracken M, Mulvey M. The Canadian Antimicrobial Resistance Alliance (CARA) and Hoban DJ. Antimicrobial resistant pathogens in Canadian hospitals: results of the Canadian Ward Surveillance Study CANWARD 2007. Can. J. Infect. Dis. & Med. Micro.20 (Suppl A):4-71 (2009). Zhanel, G.G. Zniezek, G., Schweizer, F., Zelenitsky, S., Lagace-Wiens, R.S., Rubinstein, E., Gin, A,S., Hoban, D.J., Karlowsky, J.A. Ceftaroline: a novel broad-spectrum cephalosporin with activity against meticillin-resistant Staphylococcus aureus. Drugs, 69, 809-831 (2009).