研究领域

Analytical Chemistry

The development and application of new plasma techniques for the atomic spectroscopic analysis of diverse materials is a major focus of this research group. Included in this work is the design of atomic emission and mass spectrometry instrumentation employing glow discharge (GD) sources. Plasma sources have been developed for the analysis of electronic grade materials, polymers and a variety of layered systems. Instrumentation developed in the Marcus laboratory is now commercially available from a number of manufacturers. A continuing area of emphasis has been the development of novel detection methods for liquid chromatography. Low-pressure plasma sources provide unambiguous molecular and elemental analysis information, which is vital for biological systems regarding the essential and toxic character of different metal species. A recent development has been the use of a low lower atmospheric pressure plasma for the sampling of capillary separations. This plasma offers excellent absolute sensitivities on a platform that is readily employed with lab-on-a-chip experiments. The most recent area of liquid chromatography development is a new class of channeled-polymer fibers as stationary phases, providing very efficient solution flow along with high surface areas.

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Abby J. Schadock-Hewitt, Jennifer J. Pittman, Kenneth A. Christensen, and R. Kenneth Marcus, “Head Group-Modified Lipid Surface Modification for Highly Selective Analyte Extractions on Capillary-Channeled Polymer (C-CP) Fibers”, Analyst, 139, 2108-2113, 2014. Abby J. Schadock-Hewitt and R. Kenneth Marcus, “Initial Evaluation of Protein A-Modified Capillary-Channeled Polymer Fibers for the Capture and Recovery of Immunoglobulin G”, J. Sep. Sci., 37, 495-504, 2014. Richard Russo, Benjamin T. Manard, Jhanis J Gonzalez, Arnab Sarkar, Meirong Dong, Jose R. Chirinos, Xianglei Mao, and R. Kenneth Marcus, “Liquid Sampling-Atmospheric Pressure Glow Discharge (LS-APGD) as a Secondary Excitation Source: Assessment of Plasma Characteristics”, Spectrochim. Acta, Part B, 94, 39-47, 2014. Zhengxin Wang and R. Kenneth Marcus, “Determination of Pore Size Distributions in Capillary-Channeled Polymer (C-CP) Fiber Stationary Phases by Inverse Size-Exclusion Chromatography (iSEC) and Implications for Fast Protein Separations”, J. Chromatogr. A,1351, 82-89, 2014. Benjamin T. Manard, Jhanis J. Gonzalez, Arnab Sarkar, Xianglei Mao, Lynn X. Zhang, Stefanie Konneger-Kappel, R. Kenneth Marcus, and Richard E. Russo, “Investigation of Spectrochemical Matrix Effects in the Liquid Sampling-Atmospheric Pressure Glow Discharge (LS-APGD) Source”, Spectrochim. Acta, Part B, in press. Lynn X. Zhang, Benjamin T. Manard, R. Kenneth Marcus, “Evaluation of the Operating Parameters of the Liquid Sampling-Atmospheric Pressure Glow Discharge (LS-APGD) Ionization Source for Elemental Mass Spectrometry”, Anal. Bioanal. Chem., in press. Benjamin T. Manard, Stefanie Konegger-Kappel, Jhanis J. Gonzalez, Jose Chirinos, Meirong Dong, Xianglei Mao, R. Kenneth Marcus*, and Richard E. Russo, Liquid Sampling-Atmospheric Pressure Glow Discharge as a Secondary Excitation Source for Laser Ablation-Generated Aerosols: Parametric Dependences and Robustness to Particle Loading”, Appl. Spectrosc., in press. Carolyn Q. Burdette and R. Kenneth Marcus, “Solid Phase Extraction of Proteins from Buffer Solutions Employing Capillary Channeled Polymer (C-CP) Fibers as the Stationary Phase”, Analyst, 138, 1098-1106, 2013. Abby J. Schadock-Hewitt, Jennifer J. Pittman, Kathryn A. Stevens, and R. Kenneth Marcus, “Extrusion-Based Differences in Two Types of Nylon 6 Capillary-Channeled Polymer (C-CP) Fiber Stationary Phases as Applied to the Separation of Proteins via Ion Exchange Chromatography”, J. Appl. Polym. Sci., 128,1257-1265, 2013. Carolyn Q. Burdette and R. Kenneth Marcus, “In-line Desalting of Proteins from Buffer Solutions Prior to ESI-MS Analysis via a Capillary-Channeled Polymer Fiber Microcolumn”, J. Am. Soc. Mass Spectrom., 24, 975-978, 2013. Chittaranjan Kole, Phullara Kole, K. Manoj Randunu, Poonam Choudhary, Ramakrishna Podila, Pu Chun Ke, Apparao M. Rao, and R. Kenneth Marcus, “Nanobiotechnology can boost crop production and quality: first evidence from increased plant biomass, fruit yield and phytomedicine content in bitter melon (Momordica charantia)”, BMC Biotechnol., 13, 37, 2013. Benjamin T. Manard and R. Kenneth Marcus, “Optimization of Capillary-Channeled Polymer (C-CP) Fiber Stationary Phase Extractions of Proteins from MALDI-MS Suppressing Media”, Anal. Methods, 5, 3194-3200, 2013. Joaudimir Castro, M.V. Balarama Krishna, Geovannie Ojeda, and R. Kenneth Marcus, “Selenium Speciation by Liquid Chromatography Particle Beam Mass Spectrometry (LC-PB/MS): Application to Yeast and Urine Matrices”, Anal. Methods, 5, 4053-4059, 2013. R. Kenneth Marcus, Carolyn Q. Burdette, Benjamin T. Manard, and Lynn X. Zhang, “Ambient Desorption/Ionization Mass Spectrometry using a Liquid Sampling-Atmospheric Glow Discharge (LS-APGD) Ionization Source”, Anal. Bioanal. Chem., 405, 8171-8184, 2013. Carolyn Q. Burdette and R. Kenneth Marcus, “Determination of Isoflavone Content in Soy, Red Clover and Kudzu Dietary Supplement Materials by Liquid Chromatography-Particle Beam/Electron Ionization Mass Spectrometry (LC-PB/EIMS)”, J. AOAC Int., 96, 925-932, 2013. K. Manoj Randunu and R. Kenneth Marcus, “Initial Evaluation of Protein Throughput and Yield Characteristics on Nylon 6 Capillary-Channeled Polymer (C-CP) Fiber Stationary Phases by Frontal Analysis”, Biotechnol. Prog., 29, 1222-1229, 2013. Jennifer J. Pittman, Paul J. Kowalski, and R. Kenneth Marcus, “Capillary-Channeled Polymer (C-CP) Films as Processing Platforms for Protein Analysis by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (MALDI-MS)”, J. Am. Soc. Mass Spectrom. 23, 102-107, 2012. C. Derrick Quarles, Jr., Anthony J. Carado, Charles J. Barinaga, and David W. Koppenaal, R. Kenneth Marcus, “Liquid Sampling-Atmospheric Pressure Glow Discharge (LS-APGD) Ionization Source for Elemental Mass Spectrometry: Preliminary Parametric Evaluation and Figures of Merit”, Anal. Bioanal. Chem. 402, 261-268, 2012. Anthony J. Carado, C. Derrick Quarles, Jr., Andrew M. Duffin, Charles J. Barinaga, Richard Russo, R. Kenneth Marcus, Gregory Eiden, and David W. Koppenaal, "Femtosecond Laser Ablation Particle Introduction to a Liquid Sampling-Atmospheric Pressure Glow Discharge Ionization Source", J. Anal. At. Spectrom. 27, 385-389, 2012. C. Derrick Quarles, Jr., Benjamin T. Manard, Carolyn E. Quarles, and R. Kenneth Marcus, “Roles of Electrode Material and Geometry in Liquid Sampling-Atmospheric Pressure Glow Discharge (LS-APGD) Microplasma Emission Spectroscopy”, Microchem. J. 105, 48-55, 2012. K. Manoj Randunu and R. Kenneth Marcus, “Microbore Polypropylene Capillary Channeled Polymer (C-CP) Fiber Columns for Rapid Reversed Phase HPLC of Proteins”, Anal. Bioanal. Chem., 404, 721-729, 2012. Benjamin T. Manard, and R. Kenneth Marcus, “Capillary Channeled Polymer (C-CP) Fibers as a Stationary Phase for Sample Clean-Up of Protein Solutions for Matrix-Assisted Laser/Desorption Ionization Mass Spectrometry”, J. Am. Soc. Mass Spectrom. 23, 1419-1423, 2012. C. Derrick Quarles Jr., Jhanis Gonzalez, Inhee Choi, Javier Ruiz, Xianglei Mao, R. Kenneth Marcus, and Richard Russo, “Liquid Sampling-Atmospheric Pressure Glow Discharge Optical Emission Spectroscopy (LS-APGD-OES) Detection of Laser Ablation Produced Particles: A Feasibility Study”, Spectrochim. Acta, Part B 76, 190-196, 2012. K. Manoj Randunu, Simone DiMartino, and R. Kenneth Marcus, “Dynamic Evaluation of Polypropylene Capillary-Channeled Fibers as a Stationary Phase in High Performance Liquid Chromatography”, J. Sep. Sci. 35, 3270-3280, 2012.