Coombs, Kevin M. - University of Manitoba - Department of Medical Microbiology and Infectious Diseases

研究领域

The goals of my research program are to better understand virus structure, function, assembly,and pathogenesis

近期论文

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Dryden, K.A., Wang, G., Yeager, M., Nibert, M.L., Coombs, K.M., Furlong, D.B., Fields, B.N., and T.S. Baker. (1993). Early steps in reovirus infection are associated with dramatic changes in supramolecular structure and protein conformation: Analysis of virions and subviral particles by cryoelectron microscopy and image reconstruction. J. Cell Biol. 122: 1023-1041. [Cover illustration] . PMID: 8394844 Coombs, K.M., Mak, S.-C., and Cox, L. (1994). Studies of the major reovirus core protein σ2: Reversion of the assembly-defective mutant tsC447 is an intragenic process and involves back mutation of Asp-383 to Asn. J. Virol. 68: 177-186. PMID: 8254727 Hazelton, P.R., and K.M. Coombs. (1995). The reovirus mutant tsA279 has temperature-sensitive lesions in the M2 and L2 genes: The M2 gene is associated with reduced viral protein production and blockade in transmembrane transport. Virology 207: 46-58. PMID: 7871752 Yin, P., Cheang, M, and K.M. Coombs. (1996). The M1 gene is associated with differences in the temperature optimum of the transcriptase activity in reovirus core particles. J. Virol. 70: 1223-1227. PMID: 8551584 Shing, M., and K.M. Coombs. (1996). Assembly of the reovirus outer capsid requires µ1/σ3 interactions which are prevented by misfolded σ3 protein in reovirus temperature-sensitive mutant tsG453. Virus Res. 46: 19-29. PMID: 9029774 Coombs, K.M.(1998). Stoichiometry of reovirus structural proteins in virus, ISVP, and core particles. Virology 243: 218-228. PMID: 9527931 Coombs, K.M.(1998). Temperature-sensitive mutants of reovirus. Curr. Topic Microbiol. Immunol. 233: 69-107. PMID: 9599922 Berry, J.M., Bérnaby,N., Coombs, K.M., and M. Butler. (1999). Production of reovirus type-1 and type-3 from Vero cells grown on solid and macroporous microcarriers. Biotech. Bioeng. 62: 12-19. PMID: 10099508 Hazelton, P.R., and K.M. Coombs. (1999). The reovirus mutant tsA279 L2 gene is associated with generation of a spike-less core particle: Implications for capsid assembly. J. Virol. 73: 2298-2308. PMID: 9971813 Mendez, I.I., L.L. Hermann, P.R. Hazelton, and K.M. Coombs. (2000). A comparative analysis of Freon substitutes in the purification of reovirus and calicivirus. J. Virol. Meth. 90:59-67. PMID: 11011081 Becker, M.M., Goral, M.I., Hazelton, P.R., Baer, G.S., Rodgers, S.E., Brown, E.G.,Coombs, K.M., and T.S. Dermody. (2001). Reovirus σNS protein localizes to viral inclusions and is required for viral assembly. J. Virol. 75:1459-1475. [Cover illustration, subsequent month’s cover. PMID: 11152519 Patrick, M., R. Duncan, andK.M. Coombs. (2001). Generation and genetic characterization of avian reovirus temperature-sensitive mutants. Virology 284:113-122. PMID 11352672 Mendez, I., Y.-M. She, W. Ens, and K.M. Coombs. (2003). Digestion pattern of reovirus outer capsid protein sigma3 determined by mass spectrometry. Virology 311:289-304. PMID: 12876456 Hermann, L.L. and K.M. Coombs. (2004). Inhibition of reovirus by mycophenolic acid is associated with the M1 genome segment. J. Virol. 78:6171-6179. PMID: 15163710 Xu, W., M.K. Patrick, P.R. Hazelton, and K.M. Coombs. (2004). Avian reovirus temperature-sensitive mutant tsA12 has a lesion in the major core protein σA and is defective in assembly. J. Virol. 78:11142-11151. PMID: 15452234 Robertson, C.R., L.L. Hermann, and K.M. Coombs. (2004). Mycophenolic acid inhibits replication of avian reovirus. Antiviral Res. 64: 55-61. PMID: 15451179 Brewster, J., A. Nartey, K.M. Coombs, and J.A. Oleszkiewicz. (2005). Enteric virus indicators of disinfection: Reovirus versus poliovirus. J. Envir. Engineer. 131:1010-1013. http://dx.doi.org/10.1061/(ASCE)0733-9372(2005)131:7(1010) Xu, W., A.T. Tran, M.K. Patrick, and K.M. Coombs. (2005). Assignment of avian reovirus temperature-sensitive mutants in recombination groups B, C, and D to genome segments. Virology 338:227-235. [Cover illustration]. PMID: 15955543 Hadžisejdić, I., K. Cheng, J. Wilkins, W. Ens, and K.M. Coombs. (2006). High-resolution mass spectrometric mapping of reovirus digestion. Rapid Comm. Mass Spectrom. 20:438-446. PMID: 16395731 Coombs, K.M. (2006). Reovirus Structure and Morphogenesis. Curr. Topic Microbiol. Immunol. 309: 117-167. PMID: 16909899 Mendez, I.I., S.G. Weiner, Y.-M. She, M. Yeager, and K.M. Coombs. (2008). Conformational changes accompany activation of reovirus RNA dependent RNA transcription. J. Struct. Biol. 162:277-289. PMID: 18321727 Tran, A.T., W. Xu, T. Racine, D.A. Silaghi, and K.M. Coombs. (2008). Assignment of avian reovirus temperature-sensitive mutants in recombination groups E, F, and G to genome segments. Virology 375:504-513. PMID: 18353422 Douville, R.N., R.-C. Su, K.M. Coombs, F.E.R. Simons, and K.T. Hayglass. (2008). Reovirus serotypes elicit distinctive patterns of recall immunity in humans. J. Virol. 82:7515-7523. PMID: 18508904 Coombs, K.M.(2008). Reoviridae: Molecular biology. In: Encyclopedia of Virology, 3rd Edition. (Mahy, B., & vanRegenmortel, M.H.V., Eds.), Vol. 4, pp. 390-399, Elsevier, Oxford, UK. ISBN: 978-0-12-374410-4 Coombs, K.M., A. Berard, W. Xu, O. Krokhin, X. Meng, J.P. Cortens, D. Kobasa, J. Wilkins, and E.G. Brown (2010). Quantitative proteomic analyses of influenza virus-infected cultured human lung cells. J. Virol. 84:10888-10906. (Spotlight article). PMID: 20702633