Cao, Jingxin - University of Manitoba - Department of Medical Microbiology and Infectious Diseases

研究领域

understanding how cells react to defend a virus infection and how a virus counteracts such cellular defense in order to replicate in its host cells. Our ultimate goal is to utilize the knowledge generated from such studies to design better therapeutic/prophylactic agents for viral infectious diseases.

近期论文

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Role of the Serin-Threonine Kinase PAK-1 in Myxoma Virus Replication J. B. Johnston, J. W. Barrett, Wen Chang, Che-Sheng Chung, W. Zeng, Jennefer Masters, M. Mann, Fuan Wang, Jingxin Cao , and Grant McFadden, Journal of Virology 2003, 77(10):5877-5888 Activation of AP-1 signal transduction pathway by SARS Coronavirus nucleocapsid protein Runtao He, A. Leeson, A Andonov, Y. Li, N. Bastien, Jingxin Cao , C. Osipwy, F. Dobie, T. Cutts, M. Ballantine, and X. Li. Biochemical and Biophysical Research Communications 2003, 311:870-876 Analysis of multimerization of the SARS coronavirus nucleocapsid protein. He R, Dobie F, Ballantine M, Leeson A, Li Y, Bastien N, Cutts T, Andonov A, Cao J , Booth TF, Plummer FA, Tyler S, Baker L, Li X. Biochem Biophys Res Commun. 2004 Apr 2;316(2):476-83. Potent and selective inhibition of SARS coronavirus replication by aurintricarboxylic acid. He R, Adonov A, Traykova-Adonova M, Cao J , Cutts T, Grudesky E, Deschambaul Y, Berry J, Drebot M, Li X. Biochem Biophys Res Commun. 2004 Aug 6;320(4):1199-203. Characterization of protein-protein interactions between the nucleocapsid protein and membrane protein of the SARS coronavirus He R, Leeson A, Ballantine M, Andonov A, Baker L, Dobie F, Li Y, Bastien N, Feldmann H, Strocher U, Theriault S, Cutts T, Cao J , Booth TF, Plummer FA, Tyler S, Li X. Virus Res. 2004 Oct;105(2):121-5. Immunization with modified vaccinia virus Ankara based recombinant SARS vaccine is associated with enhanced hepatitis in ferrets Hana Weingartl, Markus Czub , Stefanie Czub, James Neufeld, Peter Marszal, Jason Gren, Greg Smith, Shane Jones, Roxanne Proulx, Yvonne Deschambault, Elsie Grudeski, Anton Andonov, Runtao He, Yan Li, John Copps, Allen Grolla, Daryl Dick, Jody Berry, Shelley Ganske, Lisa Manning, Jingxin Cao, Journal of Virology 2004, 78(22):12672-12676 Evaluation of modified vaccinia virus Ankara based recombinanr SARS vaccine in ferrets Markus Czub, Hana Weingartl, Stephanie Czub, Runtao He, Jingxin Cao, Vaccine 2005, 23(17-18):2271-2277 Aurintricarboxylic acid inhibits the early stage of vaccinia virus replication by targeting both cellular and viral factors Myskiw C, Deschambault Y, Jefferies K, He R, Cao J ., J. Virol. 2007, 81:3027-3032 RIG-I mediates the co-induction of tumor necrosis factor and type I interferon elicited by myxoma virus in primary human macrophages. Wang F, Gao X, Barrett JW, Shao Q, Bartee E, Mohamed MR, Rahman M, Werden S, Irvine T, Cao J , Dekaban GA, McFadden, G. PLoS Pathog. 2008, 11;4(7):e1000099. Antagonizing activity of vaccinia virus E3L against human interferons in Huh7 cells. Arsenio J, Deschambault Y, Cao J . Virology. 2008, 20;377(1):124-32. Vaccinia virus E3L suppresses cytokine expression through inhibition of p38, NF-?B and IRF3 activation Chad Myskiw, Janilyn Arsenio, Rebekah van Bruggen, Yvon Deschambault, Jingxin Cao, (manuscript in preparation)