Werbowetski-Ogilvie, Tamra - University of Manitoba - Department of Biochemistry and Medical Genetics

个人简介

Dr. Tamra Werbowetski-Ogilvie received her HSBc of Science in Biology at the University Western Ontario in 2000. She completed her PhD in the Department of Neurology & Neurosurgery, Montreal Neurological Institute, McGill University in 2005. Dr. Werbowetski-Ogilvie completed her postdoctoral training at McMaster University in the area of human embryonic stem cells in 2010 under the supervision of Dr. Mick Bhatia following which she joined the University of Manitoba as a Principal Investigator in the Department of Biochemistry & Medical Genetics and the Regenerative Medicine Program in November, 2010. Dr. Werbowetski-Ogilvie currently holds a Tier II Canada Research Chair in Neuro-Oncology and Human Stem Cells.

研究领域

Identification of novel molecular targets of malignant brain tumorigenesis using human ES cell-based model systems

近期论文

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Liang L*, Aiken C*, McClelland R, Coudière Morrison L, Tatari N, Remke M, Ramaswamy V, Issaivanan M, Ryken T, Del Bigio MR, Taylor M, Werbowetski-Ogilvie T. 2015. Characterization of novel biomarkers for subtype-specific medulloblastoma cell phenotypes. Oncotarget, 6(36): 38881-38900.*These authors contributed equally to this work. Kaur R, Coudière Morrison L, Aiken C, Rao R, Del Biogio MR, Rampalli S, Werbowetski-Ogilvie TE. 2015. OTX2 exhibits cell context-dependent effects on cellular and molecular properties of human embryonic neural precursors and medulloblastoma cells. Disease Models & Mechanisms, 8(10): 1295-1309. Coudière Morrison M*, McClelland R*, Aiken C, Bridges M, Wang X, Del Bigio MR, Taylor MD, Werbowetski-Ogilvie TE. 2013. Deconstruction of medulloblastoma cellular heterogeneity reveals differences between the most highly invasive and self-renewing phenotypes. Neoplasia, 15(4):384-398. Werbowetski-Ogilvie TE*, Coudière Morrison L, Fiebig-Comyn A, Bhatia M*. 2012. In vivo generation of neural tumors from neoplastic pluripotent stein cells models early human pediatric brain tumor formation. Stem Cells. 30(3): 392-404.*Denotes co-corresponding authorship Werbowetski-Ogilvie TE, Bossé M, Stewart M, Schnerch A, Ramos-Mejia R, Rouleau A, Wynder T, Smith MJ, Dingwall S, Carter T, Williams C, Harris C, Dolling J, Wynder C, Boreham D, Bhatia M. 2009. Characterization of human embryonic stem cells with features of neoplastic progression. Nature Biotechnology. 27:91-97.