Triggs-Raine, Barbara - University of Manitoba - Department of Biochemistry and Medical Genetics

个人简介

Dr. Barbara Triggs-Raine received her B.Sc. and Ph.D. degrees from the University of Manitoba. Her post-doctoral training in the molecular basis of human genetic disease was done in the lab of Dr. Roy Gravel at The Hospital for Sick Children in Toronto and the McGill University-Montreal Children’s Hospital Research Institute. Dr. Triggs-Raine is presently Associate Head and Professor in the Department of Biochemistry and Medical Genetics and cross-appointed in the Department of Pediatrics and Child Health at the University of Manitoba. She serves as the Chair of the Research Advisory Committee for Research Manitoba and is a member of the Board for Research Manitoba, the Board of the Children’s Hospital Research Institute of Manitoba, and as a member of the CancerCare Manitoba Foundation’s Program Grants and Awards Committee.

研究领域

Lysosomal storage disorders including genetic, biochemical and animal models aimed at determining the function of hyaluronidases in health and disease; Identification and characterization of disease genes in unique populations

近期论文

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Chowdhury B, Hemming R, Faiyaz S, Triggs-Raine B. Hyaluronidase 2 (HYAL2) is expressed in endothelial cells, as well as some specialized epithelial cells, and is required for normal hyaluronan catabolism. Histochem Cell Biol. 2016 Jan;145(1):53-66. doi: 10.1007/s00418-015-1373-8. Epub 2015 Oct 29. Armistead J, Patel N, Wu X, Hemming R, Chowdhury B, Basra GS Del Bigio MR, Ding H, Triggs-Raine B. (2015) Growth arrest in the ribosomopathy, Bowen-Conradi syndrome, is due to dramatically reduced cell proliferation and a defect in mitotic progression. BBA Mol Basis Dis 1852:1029-1037. Walia JS, Altaleb N, Bello A, Kruck C, LaFave MC, Varshney GK, Burgess S, Chowdhury B, Hurlbut D, Hemming R, Kobinger GP, Triggs-Raine B. (2015) Long term correction of Sandhoff disease following intravenous delivery of rAAV9 to mouse neonates. Molecular Therapy 23 (3):414-422. Chowdhury B, Hemming R, Hombach-Klonisch S, Flamion B, Triggs-Raine B. (2013) Murine hyaluronidase 2-deficiency results in extracellular hyaluronan accumulation and severe cardio-pulmonary dysfunction. J. Biol. Chem 288: 520-528. Triggs-Raine B, Salo T, Zhang H, Wicklow B, and Natowicz MR. Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX. (1999) Proc Natl Acad Sci 96: 6296-6300.