Rastegar, Mojgan - University of Manitoba - Department of Biochemistry and Medical Genetics

个人简介

Neural stem cell modeling to study the mechanisms of neurodevelopmental disorders Fetal Alcohol Spectrum Disorders (FASD), Autism Spectrum Disorders (ASD), and Rett Syndrome Investigating the role of epigenetics in brain development and human disease Stem cell-based gene therapy of neurological disorders

近期论文

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Liyanage VRB, Zachariah RM, Davie JR, and Rastegar M. Ethanol Deregulates Mecp2/MeCP2 in Differentiating Neural Stem Cells via Interplay Between 5-methylcytosine and 5-hydroxymethylcytosine at the Mecp2 Regulatory Elements. Experimental Neurology 2015; 265 102-117. Doi: 10.1016/j.expneurol.2015.01.006 Olson CO*, Zachariah RM*, Ezeonwuka CD*, Liyanage VRB, and Rastegar M. Brain Region-Specific Expression of MeCP2 Isoforms Correlates with DNA Methylation within Mecp2 Regulatory Elements. PLOS ONE 2014; 9(3) 1-16: e90645. Doi: 10.1371/journal.pone.0090645*equal contribution Yasui DH, Aflatooni AO, Gonzales ML, Hu DJ, Gavino BJ, Golub MS, Vincent JB, Schanen NC, Olson CO, Rastegar M, and LaSalle JM. Mice with an Isoform-ablating Mecp2 exon 1 Mutation Recapitulates the Neurologic Deficits of Rett syndrome. Human Molecular Genetics 2014; 23(9):2447-58. Doi: 10.1093/hmg/ddt640. Liyanage VRB, Zachariah RM, and Rastegar M. Decitabine Alters the Expression of Mecp2 Isoforms via Dynamic DNA Methylation at the Mecp2 Regulatory Elements in Neural Stem Cells. Molecular Autism 2013; 4:46. 1-21. Doi:10.1186/2040-2392-4-46 Rastegar M, Hotta A, Pasceri P, Makarem M, Cheung A, Elliot S, Adachi M, Jones FS, Park KJ, Clarke I, Dirks P, and Ellis J. MECP2 Isoform-Specific Vectors with Regulated Expression for Rett Syndrome Gene Therapy. PLOS ONE 2009; 4(8): 1-15. e6810. Doi: 10.1371