Nachtigal, Mark - University of Manitoba - Department of Biochemistry and Medical Genetics

个人简介

Dr. Mark Nachtigal received his B.Sc. (Biology) and Ph.D. (Molecular Endocrinology) degrees from the University of Manitoba. His post-doctoral research was conducted in Dr. Holly Ingraham’s laboratory at the University of California, San Francisco in the area of mammalian reproductive tract development. Throughout his graduate and post-graduate training his research projects retained a link to human reproductive cancer biology. In 1998, Dr. Nachtigal was recruited to Dalhousie University as the Rossetti Scholar for Cancer Research to study human epithelial ovarian cancer (EOC). While at Dalhousie University he served as the co-chair of the Nova Scotia Cancer Research Training Program (2006-08) and as a member of the CIHR Institute of Cancer Research Advisory Board. Dr. Nachtigal returned to Manitoba in 2010 to continue his research on EOC. He is currently an Associate Professor in the Departments of Biochemistry & Medical Genetics, and Obstetrics, Gynecology, and Reproductive Sciences, as well as being a Senior Scientist in the Research Institute in Oncology & Hematology at CancerCare Manitoba.

研究领域

Investigation of human ovarian cancer using cellular, molecular and animal models to study biology, and epidemiology to study parameters affectinbg patient outcome.

近期论文

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Ali J, BJ Lagasse, AJ Minuk, AJ Love, AI Moraya, L Lam, G Arthur, SB Gibson, LC Morrison, TE Werbowetski-Ogilvie, Y Fu, MW Nachtigal. 2015. Differential cellular responses induced by dorsomorphin and LDN-193189 in chemotherapy-sensitive and chemotherapy–resistant human epithelial ovarian cancer cells. International Journal of Cancer 136:E455-E469. doi: 10.1002/ijc.29220 Thériault, BL, L. Portelance, A-M. Mes-Masson, and MW Nachtigal. Establishment of primary cultures from ovarian tumour tissue and ascites fluid. 2013. In Ovarian Cancer Research, A Malek, Ed., Humana Press. Methods in Molecular Biology 1049: 323-36. doi: 10.1007/978-1-62703-547-7_24. Thériault, BL and MW Nachtigal. 2011. Human ovarian cancer cell morphology, motility, and proliferation are differentially influenced by autocrine TGF beta superfamily signaling. Cancer Letters. 313: 108-121. doi:10.1016/j.canlet.2011.08.033 Mujoomdar, ML, LM Hogan, AL Parlow and MW Nachtigal. 2011. Pcsk6 mutant mice exhibit progressive loss of ovarian function, altered gene expression, and formation of ovarian pathology. Reproduction 141(3): 343-355. doi: 10.1530/REP-10-0451 Thériault, BL, TG Shepherd, ML Mujoomdar and MW Nachtigal. 2007. BMP4 induces EMT and Rho GTPase activation in human ovarian cancer cells. Carcinogenesis 28(6): 1153-1162. doi: 10.1093/carcin/bgm015