Mowat, Michael - University of Manitoba - Department of Biochemistry and Medical Genetics

研究领域

My laboratory is interested in the the Deleted in Liver Cancer(Dlc)-1 & -2 tumor suppressor genes and their role in tumor progression. These tumor suppressor genes code for RhoGap proteins and are found inactivated in many tumor types. We are using mouse cancer models with these genes turned off to study their role in metastasis, anticancer drug response and signaling by the phospholipid second messenger ceramide.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Dlc1 interaction with non-muscle myosin heavy chain II-A (Myh9) and Rac1 activation. Sabbir MG, Dillon R, Mowat MR. . Biol Open. 2016 Apr 15;5(4):452-60. doi: 10.1242/bio.015859. The Deleted in Liver Cancer 1 (Dlc1) tumor suppressor is haploinsufficient for mammary gland development and epithelial cell polarity. Basak P, Dillon R, Leslie H, Raouf A, Mowat MR.. BMC Cancer. 2015 Sep 9;15(1):630. doi: 10.1186/s12885-015-1642-x. The Role of Dlc1 Isoform 2 in K-Ras2(G12D) Induced Thymic Cancer. Sabbir MG, Prieditis H, Ravinsky E, Mowat MR. PLoS One. 2012;7(7):e40302. Epub 2012 Jul 5. Duplication of sub-cytoband 11E2 of chromosome 11 is always associated with accelerated tumor development in v-abl/myc induced mouse plasmacytomas. Wiener, F., Schmalter, A.K., Mowat, M. R. A. and Mai, S. Genes & Cancer 1( 8): 847-858 (2010). The Dynamics of Cardiolipin synthesis post mitochondrial fusion. Xu, F., McBride, H., Acehan, D., Vaz, F., Houtkooper, R., Lee, R., Mowat, M. Hatch, G. Biochim Biophys Acta. -Biomembranes (8):1577-85. Epub 2010 Apr 29. (2010). Identification and characterization of Dlc1isoforms in the mouse and study of the biological function of a single gene trapped isoform. Sabbir, M.G., Wigle, N., Shauna Loewen, S., Gu. Y., Buse C., Hicks G.G., Mowat M.R.A. BMC Biology 8(1): 17-38 (2010).