Merz, David - University of Manitoba - Department of Biochemistry and Medical Genetics

个人简介

Dr. David Merz did his BSc(Hons) degree in the Biology Department of McGill University, graduating in 1989. His PhD was also in the Biology Department of McGill University, graduating in 1994 (supervisor Dr. Pierre Drapeau). The subject of his thesis was synapse formation between neurons. Postdoctoral training was done at the University of Toronto, supervised by Dr. Joseph Culotti at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital. There he began using C. elegans as a model system to study cell and growth cone migrations during development. Dr. Merz has been at the University of Manitoba since 2001

研究领域

Cell migrations and axon guidance, using the model organism C. elegans. Emphasis on forward genetics and molecular biology to study the regulation and guidance of cell migrations and to identify novel genes and interactions between signalling pathways in development.

近期论文

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Adlimoghaddam A, O’Donnell MJ, Kormish J, Banh S, Treberg JR, Merz D and Weihrauch D. Ammonia excretion in Caenorhabditis elegans: Physiological and molecular characterization of the rhr-2 knock-out mutant. Comparative Biochemistry and Physiology: part A. Accepted Chatel A , Hemming R , Hobert J , Natowicz MR , Triggs-Raine B , Merz DC. The C. elegans hyaluronidase: a developmentally significant enzyme with chondroitin-degrading activity at both acidic and neutral pH. Matrix biology: journal of the International Society for Matrix Biology, 29(6) PubMed ID: 20576486 Schwabiuk M , Coudiere L , Merz DC. SDN-1/syndecan regulates growth factor signaling in distal tip cell migrations in C. elegans. Developmental biology, 334(1) PubMed ID: 19631636 Merz DC , Alves G , Kawano T , Zheng H , Culotti JG. UNC-52/perlecan affects gonadal leader cell migrations in C. elegans hermaphrodites through alterations in growth factor signaling. Developmental biology, 256(1) PubMed ID: 12654300 Merz DC , Zheng H , Killeen MT , Krizus A , Culotti JG. Multiple signaling mechanisms of the UNC-6/netrin receptors UNC-5 and UNC-40/DCC in vivo. Genetics, 158(3) PubMed ID: 11454756