Leygue, Etienne - University of Manitoba - Department of Biochemistry and Medical Genetics

研究领域

Differential gene expression during breast tumorigenesis and breast tumor progression

近期论文

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Dynamic Histone Acetylation of H3K4me3 Nucleosome Regulates MCL1 Pre-mRNA Splicing. Khan DH, Gonzalez C, Tailor N, Hamedani MK, Leygue E., Davie JR. J Cell Physiol. 2016 Oct;231(10):2196-204. doi: 10.1002/jcp.25337. Epub 2016 Mar 6. Idiopathic Hypogonadotropic Hypogonadism Caused by Inactivating Mutations in SRA1. Kotan LD, Cooper C, Darcan Ş, Carr IM, Özen S, Yan Y, Hamedani MK, Gürbüz F, Mengen E, Turan İ, Ulubay A, Akkuş G, Yüksel B, Topaloğlu AK, Leygue E.. J Clin Res Pediatr Endocrinol. 2016 Jun 5;8(2):125-34. doi: 10.4274/jcrpe.3248. Epub 2016 Apr 18. The steroid receptor RNA activator protein (SRAP) controls cancer cell migration/motility. Yan Y, Cooper C, Hamedani MK, Guppy B, Xu W, Tsuyuki D, Zhang C, Nugent Z, Blanchard A, Davie JR, McManus K, Murphy LC, Myal Y, Leygue E.. FEBS Lett. 2015 Dec 21;589(24 Pt B):4010-8. doi: 10.1016/j.febslet.2015.11.007. Epub 2015 Nov 17. Claudin 1 in breast cancer. Zhou, B., Moodie, A., Blanchard, A., Leygue E.., Myal, Y., J. Clin.Med. 4 (12): 1960-1976, 2015 The Steroid Receptor RNA protein (SRAP) controls cancer cell migration/motility. Yan, Y., Cooper, C., Hamedani, K.H., Guppy, B., Xu, W., Tsuyuki, D., Zhang, C., Nugent, Z., Blanchard, A., Davie, J.R., McManus, K., Murphy, L. C., Myal, Y., Leygue E.. Febs Let. S0014-5793(15)00978-3. doi: 10.1016/j.febslet.2015.11.007. [Epub ahead of print], 2015 PDK2 Mediated Alternative Splicing Switches Bnip3 From Cell Death to Cell Survival. Gang, H., Dhingra, R., Lin, J., Hai, Y., Aviv, Y., Margulets, V., Hamedani, M., Thanasupawat, T., Leygue E.., Klonisch, T., Davie, J.R., Kirschenbaum, L.A. J Cell Biol. 210 (7): 1101-1115, 2015 Claudin 1 Promotes Migration and Increases Sensitivity to Tamoxifen and Anticancer Drugs in Luminal-like Human Breast Cancer Cells MCF7. Zhou B, Blanchard A, Wang N, Ma X, Han J, Schroedter I, Leygue E, Myal Y. Cancer Invest. 2015 Aug 14:1-11 Blanchard AA, Ezzati P, Shamshurin D, Nistor AC, Leygue E, Wilkins JA, Myal Y. Towards further defining the proteome of mouse saliva.Proteome Sci. 2015 Feb 25;13:10. Khan DH, Gonzalez C, Cooper C, Sun JM, Chen HY, Healy S, Xu W, Smith KT, Workman JL, Leygue E, Davie JR. RNA-dependent dynamic histone acetylation regulates MCL1 alternative splicing. Nucleic Acids Res. 2014 Feb;42(3):1656-70. doi: 10.1093/nar/gkt1134. Epub 2013 Nov 14. Yan Y, Penner CC, Skliris GP, Cooper C, Nugent Z, Blanchard A, Hamedani MK, Wang X, Myal Y, Murphy LC, Leygue E.. Steroid receptor RNA activator protein (SRAP) expression as a prognostic factor in ER+ human breast tumors.J Cancer Res Clin Oncol. 2013 Aug 2. [Epub ahead of print] Blanchard AA, Ma X, Dueck KJ, Penner C, Cooper SC, Mulhall D, Murphy LC, Leygue E., Myal Y. Claudin 1 expression in basal-like breast cancer is related to patient age. BMC Cancer. 2013 May 30;13:268. doi: 10.1186/1471-2407-13-268. Yan Y, Li X, Blanchard A, Bramwell VH, Pritchard KI, Tu D, Shepherd L, Myal Y, Penner C, Watson PH, Leygue E., Murphy LC. Expression of both Estrogen Receptor-beta 1 (ER- β 1) and its co-regulator Steroid Receptor RNA Activator Protein (SRAP) are predictive for benefit from tamoxifen therapy in patients with Estrogen Receptor-alpha (ER- α )-Negative Early Breast Cancer (EBC).Ann Oncol. 2013 Aug;24(8):1986-93. doi: 10.1093/annonc/mdt132. Epub 2013 Apr 11. Leygue E., Murphy LC. A bi-faceted role of estrogen receptor β in breast cancer. Endocr Relat Cancer. 2013 May 30;20(3):R127-39. doi: 10.1530/ERC-12-0389. Print 2013 Jun. Murphy LC, Leygue E.The role of estrogen receptor- β in breast cancer. Semin Reprod Med. 2012 Jan;30(1):5-13. Epub 2012 Jan 23. Review. Cooper C, Vincett D, Yan Y, Hamedani MK, Myal Y, Leygue E. Steroid receptor RNA activator bi-faceted genetic system: Heads or Tails? Biochimie. 2011 Nov;93(11):1973-80 Gang H, Hai Y, Dhingra R, Gordon JW, Yurkova N, Aviv Y, Li H, Aguilar F, Marshall A, Leygue E, Kirshenbaum LA. A novel hypoxia-inducible spliced variant of mitochondrial death gene Bnip3 promotes survival of ventricular myocytes. Circ Res. 2011 Apr 29;108(9):1084-92. Myal Y, Leygue E, Blanchard AA. Claudin 1 in breast tumorigenesis: revelation of a possible novel "claudin high" subset of breast cancers. J Biomed Biotechnol. 2010;2010:956897. Chooniedass-Kothari S, Hamedani MK, Auge C, Wang X, Carascossa S, Yan Y, Cooper C, Vincett D, Myal Y, Jalaguier S, Cavailles V, Leygue E. The steroid receptor RNA activator protein is recruited to promoter regions and acts as a transcriptional repressor. FEBS Lett. 2010 Jun 3;584(11):2218-24. Chooniedass-Kothari S, Vincett D, Yan Y, Cooper C, Hamedani MK, Myal Y, Leygue E. The protein encoded by the functional steroid receptor RNA activator is a new modulator of ER alpha transcriptional activity. FEBS Lett. 2010 Mar 19;584(6):1174-80.