个人简介

B.S., University of Maryland, 1994; Ph.D., Stanford University, 2000. Assistant Professor, Caltech, 2005-11; Professor, 2011-.

研究领域

Our research interfaces between chemistry and biology to try to understand fundamental biological processes at the level of biochemical and biophysical principles. We focus on the following questions: How do cells efficiently and accurately sort all its proteins to the correct subcellular destinations? What are the molecular principles of recognition and regulation that underlie such complex biological phenomena? Our attention currently focuses on a pair of molecular adapters - the signal recognition particle (SRP) and the SRP receptor (SR) - that deliver newly synthesized proteins to particular membrane systems within the cell. This process is responsible for the sorting of all the ER resident and secretory proteins within the cell (accounting for roughly one third of cellular proteins) and is essential to establish and maintain the amazing degree of order and organization required to sustain life.

Biochemistry and Molecular Biophysics; Chemistry

近期论文

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Michael E. Rome, Un Seng Chio, Meera Rao, Harry Gristick, and Shu-ou Shan (2014) PNAS. "Differential gradients of interaction affinities drive efficient targeting and recycling in the GET pathway." PMID: 25368153. Saraogi I, Akopian D, Shan SO. (2014) J Cell Biol. "Regulation of cargo recognition, commitment, and unloading drives cotranslational protein targeting." PMID: 24914238. Zhang X and Shan SO. (2014) Annu Rev Biophysics. "Fidelity of cotranslational protein targeting by the signal recognition particle." PMID: 24895856. Guo H, Xiong Y, Witkowski P, Cui J, Wang LJ, Sun J, Lara-Lemus R, Haataja L, Hutchison K, Shan SO, Arvan P, Liu M. (2014) J Biol Chem. "Inefficient Translocation of Preproinsulin Contributes to Pancreatic β Cell Failure and Late-onset Diabetes." PMID: 24770419. Gristick HB, Rao M, Chartron JW, Rome ME, Shan SO, Clemons WM Jr. (2014) Nature Structural and Molecular Biology. "Crystal structure of ATP-bound Get3–Get4–Get5 complex reveals regulation of Get3 by Get4." PMID: 24211265. Saraogi I and Shan SO. (2013) Biochim Biophys Acta. Co-translational protein targeting to the bacterial membrane..” PMID: 24513458. Voigts-Hoffmann F, Schmitz N, Shen K, Shan SO, Ataide SF, Ban N. (2013) Molecular Cell. "The Structural Basis of FtsY Recruitment and GTPase Activation by SRP RNA." PMID: 24727835. Shen K, Wang Y, Hwang Fu YH, Zhang Q, Feigon J, Shan SO. (2013) J Biol Chem. "Molecular mechanism of GTPase activation at the SRP RNA distal end." PMID: 24151069. Michael E. Rome, Meera Rao, William M. Clemons, and Shu-ou Shan. (2013) PNAS. Epub ahead of print. “Precise timing of ATPase activation drives targeting of tail-anchored proteins.” PMID: 23610396. von Loeffelholz, O., Knoops, K., Ariosa, A.R., Zhang, X., Karuppasamy, M., Huard, K., Schoehn, G., Berger, I., Shan, S. and Schaffitzel, C. (2013) Nat. Struct. Mol. Biol. Epub ahead of print. “Structural Basis of Signal Sequence Surveillance and Selection by the SRP-FtsY Complex.” PMID: 23563142. Nguyen, T.X., Jaru-Ampornpan, P., Lam, V.Q., Cao, P., Piszkiewicz, S., and Shan, S. (2013) J. Biol. Cell, Epub ahead of print. “Mechanism of an ATP-independent protein disaggregase. I. Structure of a membrane protein aggregate reveals a mechanism of recognition by its chaperone.” PMID: 23525109. Jaru-Ampornpan, P., Liang, F.C., Nisthal, A., Nguyen, T.X., Wang, P., Shen, K., Mayo, S.L., and Shan, S. (2013) J. Biol. Cell, Epub ahead of print. “Mechanism of an ATP-independent protein disaggregase. II. Distinct molecular interactions drive multiple steps during aggregate disassembly.” PMID: 23519468. Pierce, N.W., Lee, J.E., Liu, X., Sweredoski, M.J., Graham, R.L.J., Larimore, E.A., Rome, M., Zheng, N., Clurman, B.E., Hess, S., Shan, S. and Deshaies, R.J. (2013) Cell, 153 1-10. “Cand1 Promotes Assembly of New SCF Complexes through Dynamic Exchange of F Box Proteins.” PMID: 23453757. Akopian, D., Dalal, K., Shen, K., Duong, F., and Shan, S. (2013) J. Cell Biol., 200 (4), 397-405. “SecYEG activates GTPases to drive the completion of cotranslational protein targeting.” PMID: 23401005. Akopian, D., Shen, K., Zhang, X. and Shan, S. (2013) Annu. Rev. Biochem., Epub ahead of print. “Signal Recognition Particle: An Essential Protein Targeting Machine.” PMID: 23414305. Shen, K., Arslan, S., Akopian, D., Ha, T., and Shan, S. (2012) Nature, 492 (7428):271-5. “Activated GTPase movement on an RNA scaffold drives cotranslational protein targeting.” PMID: 23235881. Ariosa, A.R., Duncan., S., Saraogi, I., Lu, X., Brown, A., Phillips, G.J., and Shan, S. (2012) Mol. Biol. Cell. “Fingerloop activates cargo delivery and unloading during co-translational protein targeting.” PMID: 23135999. Liu, M., Lara-Lemus, R., Shan, S., Wright, J., Haataja, L., Barbetti, F., Guo, H., Larkin, D., Arvan, P. (2012) Diabetes, 61: 828-837. “Impaired cleavage of preproinsulin signal peptide linked to autosomal-dominant diabetes.” PMID: 22357960. Zhang, D. and Shan, S. (2012) J. Biol. Chem. 287(10):7652-60, “Translation elongation regulates substrate selection by the Signal Recognition Particle.” PMID: 22228766. Zhang, D., Sweredoski, M. J., Graham, R.L., Hess, S., and Shan, S. (2012) Mol. Cell Proteomics 11(2):M111.011585, “Novel proteomic tools reveal essential roles of SRP and importance of proper membrane protein biogenesis.” PMID: 22030350.