研究领域

Physical Chemistry

Research in the Casabianca group focuses on using Nuclear Magnetic Resonance (NMR) to study the interactions between nanomaterials and biological molecules. As nanotechnology becomes more prevalent in our everyday lives, it is important to understand how nano-scale systems interact with proteins, lipids, and other biological ligands. Studies involving interactions between nanomaterials and biological molecules have traditionally used low-resolution techniques such as Raman spectroscopy, electron microscopy, and circular dichroism spectroscopy. NMR, on the other hand, is a local technique capable of providing atomic-level information about the electronic environment surrounding each atom. In our lab we will use solution and solid-state NMR experiments, as well as theoretical chemical shift calculations and molecular dynamics simulations in order to shed light on the structure and dynamics of nanomaterial-ligand binding. This multidisciplinary work has applications in the areas of biomedical devices, materials science, and nanoparticle toxicity.

近期论文

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“Chirped CPMG for Well-Logging NMR Applications” L. B. Casabianca, D. Mohr, S. Mandal, Y.-Q. Song and L. Frydman, J. Magn. Reson. 2014, 242, 197-202. “Chemical Structures of Hydrazine-treated Graphene Oxide and Generation of Aromatic Nitrogen Doping” S. Park, Y. Hu, J. O. Hwang, E.-S. Lee, L. B. Casabianca, W. Cai, J. R. Potts, H.-W. Ha, S. Chen, J. Oh, S. O. Kim, Y.-H. Kim, Y. Ishii and R. S. Ruoff, Nature Communications 2012, 3, 638. “Factors Affecting DNP NMR in Polycrystalline Diamond Samples” L. B. Casabianca, A. I. Shames, A. M. Panich, O. Shenderova and L. Frydman, J. Phys. Chem. C 2011, 115, 19041-19048. “The Hydroxyl Functionality and a Rigid Proximal N are Required for Forming a Novel Non-covalent Quinine-heme Complex” J. N. Alumasa, A. P. Gorka, L. B. Casabianca, E. Comstock, A. C. de Dios and P. D. Roepe, J. Inorg. Biochem. 2011, 105, 467-475. “NMR-Based Structural Modeling of Graphite Oxide Using Multidimensional 13C Solid-State NMR and ab Initio Chemical Shift Calculations” L. B. Casabianca, M. A. Shaibat, W. W. Cai, S. Park, R. Piner, R. S. Ruoff and Y. Ishii, J. Am. Chem. Soc. 2010, 132, 5672-5676. “Distinguishing Polymorphs of the Semiconducting Pigment Copper Phthalocyanine by Solid-State NMR and Raman Spectroscopy” M. A. Shaibat, L. B. Casabianca, D. Y. Siberio-Pérez, A. J. Matzger and Y. Ishii, J. Phys. Chem. B 2010, 114, 4400-4406. “Synthesis and Structural Determination of Two Triphenyltin Thiosalicylates” R. Knighton, X. Song, R. Pike, A. C. de Dios, L. Casabianca and G. Eng, J. Coord. Chem. 2009, 62, 3110-3116. “Antimalarial Drugs and Heme in Detergent Micelles: An NMR Study” L. B. Casabianca, J. B. Kallgren, J. K. Natarajan, J. N. Alumasa, P. D. Roepe, C. Wolf, and A. C. de Dios, J. Inorg. Biochem. 2009, 103, 745-748. “Quinine and Chloroquine Differently Perturb Heme Monomer-Dimer Equilibrium” L. B. Casabianca, D. An, J. K. Natarajan, J. Alumasa, P. D. Roepe, C. Wolf and A. C. de Dios, Inorg. Chem. 2008, 47, 6077-6081. “4-N, 4-S & 4-O Chloroquine Analogues: Influence of Side Chain Length and Quinolyl Nitrogen pKa on Activity vs. Chloroquine Resistant Malaria” J. K. Natarajan, J. Alumasa, K. Yearick, K. Ekoue-Kovi, L. B. Casabianca, A. C. de Dios, C. Wolf and P. D. Roepe, J. Med. Chem. 2008, 51, 3466-3479. “Ab Initio Calculations of NMR Chemical Shifts” L. B. Casabianca and A. C. de Dios, J. Chem. Phys. 2008, 128, 052201. “Progress in 13C and 1H Solid State Nuclear Magnetic Resonance for Paramagnetic Systems under Very Fast Magic Angle Spinning” N. P. Wickramasinghe, M. A. Shaibat, C. R. Jones, L. B. Casabianca, A. C. de Dios, J. S. Harwood and Y. Ishii, J. Chem. Phys. 2008, 128, 052210. “Characterization of Polymorphs and Solid-State Reactions for Paramagnetic Systems by 13C Solid-State NMR and ab Initio Calculations” M. A. Shaibat, L. B. Casabianca, N. P. Wickramasinghe, S. Guggenheim, A.C. de Dios and Y. Ishii, J. Am. Chem. Soc. 2007, 129, 10968-10969.