研究领域

Bioinorganic Chemistry

Research in the Brumaghim group aims to understand how metal ions form oxygen radical species that damage DNA and cause cell death, and how antioxidants prevent this damage. Studying DNA damage inhibition by antioxidants may lead to future treatments for cancer and other diseases caused by oxidative damage. Research projects combine areas of coordination chemistry, biochemistry, and toxicology. Because of the diversity of research areas, students will develop skills in both inorganic chemistry and the biochemistry of nucleic acids and oxidative DNA damage.

近期论文

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Angelé-Martínez, C.; Goodman, C.; Brumaghim, J. L. “Metal-Mediated DNA Damage and Cell Death: Mechanisms, Detection Methods, and Cellular Consequences,” Metallomics 2014, 6, 1358-1381 (invited review). Kimani, M. M.; Bayse, C. A.; Stadelman, B. S.; Brumaghim, J. L. “Oxidation of Biologically Relevant Chalcogenones and Their Cu(I) Complexes: Insights into Selenium and Sulfur Antioxidant Activity,” Inorg. Chem. 2013, 52, 11685-11687. Stadelman, B. S.; Brumaghim, J. L. “Thione- and Selone-Containing Compounds, Their Late First Row Transition Metal Coordination Chemistry, and Their Biological Potential,” In Biochalcogen Chemistry: The Biological Chemistry of Sulfur, Selenium, and Tellurium; Bayse, C. A.; Brumaghim, J. L. Eds.; ACS Symposium Series; American Chemical Society: Washington, DC, 2013, pp. 33-70 (DOI: http://dx.doi.org/10.1021/ic401366c). Underwood, C. C.; Stadelman, B. S.; Sleeper, M. L.; Brumaghim, J. L. "Synthesis and Electrochemical Characterization of [Ru(NCCH3)6]2+, Tris(acetonitrile) Tris(pyrazolyl)borate, and Tris(acetonitrile) Tris(pyrazolyl)methane Ruthenium(II) Complexes," Inorg. Chim. Acta 2013, 405, 470-476. Kimani M. M.; Wang H. C.; Brumaghim, J. L. "Investigating the copper coordination, electrochemistry, and Cu(II) reduction kinetics of biologically relevant selone and thione compounds," Dalton Trans. 2012, 41, 5248-5259. Garcia C. R.; Angele-Martinez C.; Wilkes J. A.; Wang H. C.; Battin E. E; Brumaghim, J. L. "Prevention of iron- and copper-mediated DNA damage by catecholamine and amino acid neurotransmitters, L-DOPA, and curcumin: metal binding as a general antioxidant mechanism" Dalton Trans., 2012, 41, 6458-6467. Wang, H. C.; Brumaghim, J. L. "Polyphenol Compounds as Antioxidants for Disease Prevention: Reactive Oxygen Species Scavenging, Enzyme Regulation, and Metal Chelation Mechanisms in E. coli and Human Cells," In Oxidative Stress: Diagnostics, Prevention, and Therapy; Andreescu, S.; Hepel, M., eds.; ACS Symposium Series; American Chemical Society: Washington, DC, 2011, pp. 99-175 (DOI: 10.1021/bk-2011-1083.ch005). Verdan, A. M.; Garcia, C. R.; Wang, H. C.; Henry, W. P.; Brumaghim, J. L. "Fe(II) Binding of 3-Hydroxychromone, 5-Hydroxychromone, and Sulfonated Morin: Antioxidant Activity of Flavonoids with Competing Metal Binding Sites," J. Inorg. Biochem. 2011, 105, 1314-1322. Quarles, C. D.; Marcus, R. K.; Brumaghim, J. L. "Competitive Binding of Fe(III), Cr(III), and Ni(II) to Transferrin," J. Biol. Inorg. Chem. 2011, 16, 913-921. Kimani, M. M.; VanDerveer, D.; Brumaghim, J. L. "The Diselanylbis(1,3-dimethyl-1H-imidazol-3-ium) Dication Stabilized by the Polymeric catena-Pentachloridotricuprate(I) Anion," Acta Crystallogr. 2011, C67, m208-m210. Grimland, J.; Wu, C.; Ramoutar, R. R.; Brumaghim, J. L.; McNeill, J. "Highly Efficient Singlet Oxygen Generation by Polymer Nanoparticles," Nanoscale 2011, 3, 1451-1455. Kimani, M. M.; Bayse, C. A.; Brumaghim, J. L. "Synthesis, Characterization, and DFT Studies of Thione and Selone Cu(I) Complexes with Variable Coordination Geometries," Dalton Trans. 2011, 40, 3711-3723. Perron, N. P.; Garcia, C. R.; Pinzon, J. R.; Chaur, M. N.; Brumaghim, J. L. "Antioxidant and Prooxidant Effects of Polyphenol Compounds on Copper-Mediated DNA Damage," J. Inorg. Biochem. 2011, 105, 735-743. Battin, E. E.; Zimmerman, M. T.; Ramoutar, R. R.; Quarles, C. E.; Brumaghim, J. L. "Selenium Compounds Prevent Copper- and Iron-Mediated Oxidative DNA Damage," Metallomics 2011, 3, 503-512. Quarles, C. D.; Brumaghim, J. L; Marcus, R. K. "Instrumental Comparison of the Determination of Cr(III) Uptake by Human Transferrin," Metallomics 2010, 2, 792-799 (cover article). Perron, N. R.; Wang, H. C.; DeGuire, S. N.; Jenkins, M.; Lawson, M.; Brumaghim, J. L. "Kinetics of Iron Oxidation upon Polyphenol Binding," Dalton Trans. 2010, 41, 9982-9987. Kimani, M. M.; Brumaghim, J. L.; VanDerveer, D. "Probing the Antioxidant Action of Selenium and Sulfur Using Cu(I)-Chalcogenone Tris(pyrazolyl)methane and -borate Complexes," Inorg Chem. 2010, 49, 9200-9211. Quarles, C. D., Jr.; Brumaghim, J. L.; Marcus, R. K. "Simultaneous Multiple Element Detection by Particle Beam/Hollow Cathode-Optical Emission Spectroscopy as a Tool for Metallomic Studies: Determinations of Metal Binding with Apo-Transferrin," Metallomics 2010, 2, 154-161. Battin, E. E.; Brumaghim, J. L. "Antioxidant Activity of Sulfur and Selenium: A Review of Reactive Oxygen Species Scavenging, Glutathione Peroxidase, and Metal Binding Antioxidant Mechanisms," Cell Biochem. Biophys. 2009, 55, 1-23 (invited review). Battin, E. E.; Lawhon, A.; Hamilton, D. H.; Brumaghim, J. L. "Using Proteins in a Bioinorganic Laboratory Experiment: Iron Loading and Removal from Transferrin," J. Chem. Ed. 2009, 86, 969-972.