研究领域

Analytical Chemistry

Dr. Anker’s research uses a combination of optical spectroscopy and nanoparticle devices to study chemical and biophysical processes. The interdisciplinary research involves development and bioanalytical application of multifunctional plasmonic and fluorescent sensors and effectors. Fluorescent and plasmonic nanoparticles are increasingly used in cellular imaging because they fluoresce and scatter light so brightly that individual nanoparticles can be easily observed over extended periods. In addition, nanoparticles can act as a platform onto which many components can be loaded. By loading new components onto nanoparticle platforms, new properties are created with diverse applications.

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Chen H., Sulejmanovic D., Moore T., Colvin D.C., Qi B., Mefford O.T., Gore J.C., Alexis F., Hwu S-J., and Anker J.N.: Chemistry of Materials. “Iron-loaded magnetic nanoparticles for pH-triggered drug release and MRI imaging.” (http://dx.doi.org/10.1021/cm404168a, 2014) Anker J.N., Koo Y.E.L., and Kopelman R.: “Magnetically Guiding and Orienting Integrated Chemical Sensors.” Journal of Magnetism and Magnetic Materials. DOI: 10.1016/j.jmmm.2014.02.089i. (2014). Moore T., Chen H., Morrison R., Wang F., Anker J.N., and Alexis F.: “Nanotechnologies for Non-invasive Measurement of Drug Release.” Molecular Pharmaceutics. 11, 24-39 (2014). Wang F., Raval Y., Chen H., DesJardins J.D., Tzeng T.-R., and Anker J.N.: "Development of luminescent pH sensor films for monitoring bacterial growth through tissue." Advanced Healthcare Materials, 3, 197-204 (2014). Chen H., Qi B., Moore T., Colvin D.C., Crawford T., Gore J.C., Alexis F., Mefford O.T., and Anker J.N.: "Synthesis of bright PEGylated luminescent magnetic up-conversion nanophosphors for dual MRI and deep tissue imaging." Small, 10, 160-168 (2014). Chen H., Colvin D.C., Qi B., Moore T., He J., Mefford O.T., Alexis F., Gore J.C., Anker J.N.: “Magnetic and optical properties of multifunctional core-shell radioluminescence nanoparticles.” Journal of Materials Chemistry 22, 12802-12809, (2012). Chen H., Moore T., Qi B., Colvin D.C., Jelen E.K. Hitchcock D., He J., Mefford O.T., Alexis F., Gore J.C., Anker J.N.: “Monitoring pH-triggered Drug Release from Radioluminescent Nanocapsules with X-ray Excited Optical Luminescence.” ACS Nano, http://dx.doi.org/10.1021/nn304369m. (2013) Underwood C.C., McMillen C.D., Chen H., Anker J.N., and Kolis J.W. “Hydrothermal Chemistry, Structures, and Luminescence Studies of Alkali Hafnium Fluorides.” Inorganic Chemistry, dx.doi.org/10.1021/ic301760a (2012) Wang F., Widejko R.G., Yang Z., Nguyen K.V.T., Chen H, Fernando L.P., Christensen K.A., Anker, J.N.: “Surface-enhanced Raman scattering detection of pH with silica-encapsulated 4-mercaptobenzoic acid-functionalized silver nanoparticles.” Analytical Chemistry. 84, 8013-8019(2012). Chen, H., Rogalski M., Anker, J.N.: “Advances in functional X-ray imaging techniques and contrast agents.” Physical Chemistry Chemical Physics, 14 13469-13486 (2012) Hall, W. P.; Modica, J.; Anker, J.; Lin, Y.; Mrksich, M.; Van Duynet, R. P., A Conformation-and Ion-Sensitive Plasmonic Biosensor. Nano Letters 11 (3), 1098-1105 (2011) Yang Z., Nguyen K.V.T.; Chen H., Qian H.; Fernando L., Christensen K., Anker J.N. “Plasmonic Silver Nanobelts via Citrate Reduction in the Presence of HCl and their Orientation-Dependent Scattering Properties.” The Journal of Physical Chemistry Letters, 2, 1742-1746, (2011). Chen H., Patrick, A., Yang, Z., VanDerveer D., Anker J.N. “High-resolution chemical imaging through tissue with an X-ray scintillator sensor.” Analytical Chemistry, 83, 5045-5049, (2011). Chen H., Longfield D.E., Varahagiri V.S., Nguyen K.V.T, Patrick A.L., Qiana H., VanDerveer D.G., Anker J.N. “Optical imaging in tissue with X-ray excited luminescent sensors.” Analyst, Special Edition on Emerging Investigators 136, 3438-3445 (2011) Yang Z., Qian H, Chen H, and Anker J.N. “One-pot hydrothermal synthesis of silver nanowires via citrate reduction.” Journal of Colloid and Interface Science 32, 285-291, (2010). Bingham J.M., Anker J.N., Kreno L.E., Van Duyne R.P. “Gas Sensing with High-Resolution Localized Surface Plasmon Resonance Spectroscopy.” Journal of the American Chemical Society. 132, 17358–17359, (2010). Anker J.N., Hall W.P., Lambert M.P., Velasco P.T., Mrksich M., Klein W.L., and Van Duyne R.P.: “Detection and Identification of Bioanalytes with High Resolution LSPR Spectroscopy and MALDI Mass Spectrometry.” Journal of Physical Chemistry C., 113, 5891-5894 (2009). Biggs K.B., Camden J.P., Anker J.N., and Van Duyne R.P.: "Surface-Enhanced Raman Spectroscopy of Benzenethiol Adsorbed from the Gas Phase onto Silver Film over Nanosphere Surfaces: Determination of the Sticking Probability and Detection Limit Time," Journal of Physical Chemistry A., 113, 4581-4586 (2009). Anker J.N., Hall W.P., Lyandres O., Shah N.C., Zhao J., Van Duyne R.P.: “Biosensing with Plasmonic Nanosensors.” Nature Materials, 7, 442-453 (2008). Hall W.P., Anker J.N., Lin Y., Modica J., Van Duyne R.P., Lin Y., Mrksich M. “A Calcium-Modulated Plasmonic Switch.” J. Am. Chem. Soc., 18, 5836–5837 (2008).