肖友利 - 中国科学院大学

个人简介

招生专业 071005-微生物学 070321-化学生物学 085238-生物工程招生方向化学生物学，酶学天然产物合成生物学化学蛋白质组学教育背景 2000-09--2005-07 中科院上海有机化学研究所理学博士 1996-09--2000-07 山东大学理学学士工作简历 2012-09~现在, 中科院上海生命科学研究院, 研究员 2012-04~2012-09,美国哈佛大学医学院, Research Fellow 2011-10~2012-03,BiogenIdec, Scientist 2006-01~2011-09,美国波士顿大学化学系, 博后，助理研究员 2005-06~2005-12,通用电气全球研发中心(上海）, 主任工程师教授课程现代生物学研究方法与技术－化学分析与仪器应用微生物系统与合成生物学专题讲座-酶学与蛋白质改造植物生理与分子生物学-化学分析科研项目（ 1 ）活性分子创制中的生物合成途径解析和构建, 主持, 省级, 2015-09--2018-08 （ 2 ）磷酸裂解酶参与的碳磷键断裂自由基反应机制研究, 主持, 国家级, 2016-01--2019-12 （ 3 ）异源模块与生物底盘之间交互式作用的计算与预测, 主持, 国家级, 2013-01--2017-08 （ 4 ）生物合成途径解析, 主持, 国家级, 2013-01--2017-12 （ 5 ）国际合作CAS-JIC联合中心项目, 主持, 部委级, 2016-01--2020-12 （ 6 ）面向天然产物生物合成的人工细胞, 参与, 部委级, 2018-01--2022-12

近期论文

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（1） Insights into Pipecolic Acid Biosynthesis in Huperzia serrata, Organic Letters, 2018, 通讯作者（2） Comprehensive relative quantitative metabolomics analysis of lycopodium alkaloids in different tissues of Huperzia serrata, Synthetic and Systems Biotechnology, 2018, 通讯作者（3）活性天然产物靶标蛋白的鉴定, Target Identification of Bioactive Natural Products, 化学学报, 2018, 通讯作者（4） Development of Photoaffinity Probe for the Discovery of Steviol Glycosides Biosynthesis Pathway in Stevia rebuadiana and Rapid Substrate Screening, ACS Chem. Biol., 2018, 通讯作者（5） Systematic identification of functional residues of Artemisia annua amorpha-4,11-diene synthase, Biochemical Journal, 2017, 第 4 作者（6） Triplin, a small molecule, reveals copper ion transport in ethylene signaling from ATX1 to RAN1, PLoS Genet, 2017, 第 9 作者（7） Competitive profiling of celastrol targets in human cervical cancer HeLa cells via quantitative chemical proteomics, Mol BioSyst, 2017, 通讯作者（8） Construction of the octosyl acid backbone catalyzed by a radical S-adenosylmethionine enzyme and a phosphatase in the biosynthesis of high-carbon sugar nucleoside antibiotics, Chemical Science, 2017, 通讯作者（9） Identification and characterization of L-lysine decarboxylase from Huperzia serrata and its role in the metabolic pathway of lycopodium alkaloid., Phytochemistry, 2017, 通讯作者（10） Global transcriptome analysis of huperzia serrata and identification of critical genes involved in the biosynthesis of huperzine, BMC Genomics, 2017, 通讯作者（11） Chemical proteomics reveal CD147 as a functional target of pseudolaric acid B in human cancer cells, Chem. Commun., 2017, 通讯作者（12） Characterization of the artemisinin binding site for translationally controlled tumor protein (TCTP) by bioorthogonal click chemistry, Bioconjugate Chemistry, 2016, 通讯作者（13） Global profiling of cellular targets of gambogic acid by quantitative chemical proteomics, Chem Commun, 2016, 通讯作者（14） Profiling of Multiple Targets of Artemisinin Activated by Hemin in Cancer Cell Proteome, ACS Chemical Biology, 2016, 通讯作者（15） Structural basis of rifampin inactivation by rifampin phosphotransferase, PNAS, 2016, 第 4 作者（16） Down-regulation of Rubisco Activity by Non-enzymatic Acetylation of RbcL, Molecular Plant, 2016, 第 4 作者（17） Methylerythritol Phosphate Pathway of Isoprenoid Biosynthesis, Annual Review of Biochemistry, 2013, 通讯作者（18） Quaternary Ammonium Oxidative Demethylation: X-ray Crystallographic, Resonance Raman and UV-visible Spectroscopic Analysis of a Rieske-type Demethylase, J. Am. Chem. Soc., 2012, 第 2 作者（19） A Key Enzyme in the Methylerythritol Phosphate Pathway Using Fluoro-substituted Substrate Analogues, Organic Letter, 2011, 第 1 作者（20） Mechanistic Studies of IspH-catalyzed Reaction Using Substrate Analogue: Implications for Substrate Binding and Protonation, Angew. Chem. Int. Ed., 2011, 第 1 作者（21） IspG-catalyzed Positional Isotopic Exchange in Methylerythritol Cyclodiphosphate of the Deoxyxylulose Phosphate Pathway: Mechanistic Implications, ChemBioChem, 2011, 第 1 作者（22） Methylerythritol Cyclodiphosphate (MEcPP) in Deoxyxylulose Phosphate Pathway: Synthesis from an Epoxide and Mechanisms, Chemical Communications, 2010, 第 1 作者（23） IspG converts an epoxide substrate analog to (E)-4-hydroxy-3-methylbut-2-enyl diphosphate: implications for IspG catalysis in isoprenoid biosynthesis, J. Am. Chem. Soc., 2009, 第 2 作者（24） Revisiting the IspH Catalytic System in the Deoxyxylulose Phosphate Pathway: Achieving High Activity, J. Am. Chem. Soc., 2009, 第 1 作者（25） Synthesis of [1-13C] and Stereo-specifically [1-2H] Labeled Fluorinated Substrate Analogues of IspH Enzyme in the Deoxyxylulose Phosphate Pathway, Tetrahedron Letter, 2009, 第 1 作者（26） IspG Enzyme Activity in the Deoxyxylulose Phosphate Pathway: Roles of the Iron-Cluster, Biochemistry, 2009, 第 1 作者（27） Prenyltransferase Substrate Binding Pocket Flexibility and Its Application in Isoprenoid Profiling, Molecular BioSystems, 2009, 第 1 作者（28） Synthesis of P-metlylase Substrates of the Bialaphos Biosynthetic Pathway, Organic Letter, 2008, 第 1 作者（29） Mechanistic Studies of IspH in the Deoxyxylulose Phosphate Pathway: Heterolytic C-O Bond Cleavage at C4 Position, J. Am. Chem. Soc., 2008, 第 1 作者（30） IspH Protein of the Deoxyxylulose Phosphate Pathway: Mechanistic Studies with C1 Deuterium Labeled Substrate and Fluorinated Analogue, Angew. Chem. Int. Ed., 2008, 第 1 作者（31） Intramolecularly Dinuclear Magnesium Complex Catalyzed Copolymerization of Cyclohexene Oxide with CO2 under Ambient CO2 Pressure: Kinetics and Mechanism, Macromolecules, 2006, 第 1 作者（32） Copolymerization of Cyclohexene Oxide with CO2 Using Intramolecularly Dinuclear Zinc Catalysts, Chem.-Eur. J., 2005, 第 1 作者