Matile, Stefan - University of Geneva - Department of Organic Chemistry

个人简介

Stefan Matile is a Full Professor in the Department of Organic Chemistry at the University of Geneva and a founding member of the National Centre of Competence in Research (NCCR) Chemical Biology and the NCCR Molecular Systems Engineering. In 2010, he became an ERC Advanced Investigator. He is the co-author of more than 270 publications, many in top journals (48 JACS, etc), and has delivered more than 240 lectures all over the world. Half of the more than 90 junior researchers he has trained so far (PhD, postdoc) are now active in academia (China, France, Germany, India, Italy, Japan, Spain, Switzerland, USA, etc); others preferred a career in industry (Firmenich, Nestle, DuPont Geneva, Siegfried, BASF, Roche, etc), or elsewhere. Educated at the University of Zurich (PhD, with Wolf Woggon) and Columbia University in New York (postdoc, with Koji Nakanishi), he started his independent academic career as an Assistant Professor at Georgetown University, Washington DC, before moving to Geneva.

研究领域

At the interface of synthetic organic, biological and supramolecular materials chemistry. Emphasis is on functional molecular and supramolecular systems that are synthesized from scratch.

近期论文

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Benz, S.; Mareda, J.; Besnard, C.; Sakai, N.; Matile, S. “Catalysis with Chalcogen Bonds: Neutral Benzodiselenazole Scaffolds with High-Precision Selenium Donors of Variable Strength” Chem. Sci. 2017, in press López-Andarias, J.; Frontera, A.; Matile, S. “Anion-π Catalysis on Fullerenes” J. Am. Chem. Soc. 2017, 139, 13296-13299 Liu, L.; Cotelle, Y.; Bornhof, A. -B.; Besnard, C.; Sakai, N.; Matile, S. “Anion-π Catalysis of Diels-Alder Reactions” Angew. Chem. Int. Ed. 2017, 56, 13066-13069 Derivery, E.; Bartolami, E.; Matile, S.; Gonzalez-Gaitan, M. “Efficient Delivery of Quantum Dots into the Cytosol of Cells Using Cell-Penetrating Poly(disulfide)s” J. Am. Chem. Soc. 2017, 139, 10172-10175 Wang, C.; Matile, S. “Anion-π Catalysts with Axial Chirality” Chem. Eur. J. 2017, 23, 11955-11960 Neuhaus, F.; Zobi, F.; Brezesinski, G.; Dal Molin, M.; Matile, S.; Zumbuehl, A. “Correlation of Surface Pressure and Hue of Planarizable Push-Pull Chromophores at the Air/Water Interface” Beilstein J. Org. Chem. 2017, 13, 1099-1105 Akamatsu, M.; Sakai, N.; Matile, S. “Electric-Field-Assisted Anion-π Catalysis” J. Am. Chem. Soc. 2017, 139, 6558-6561 Zong, L.; Bartolami, E.; Abegg, D.; Adibekian, A.; Sakai, N.; Matile, S. “Epidithiodiketopiperazines: Strain-Promoted Thiol-Mediated Cellular Uptake at the Highest Tension” ACS Cent. Sci. 2017, 3, 449-453 Liu, L.; Cotelle, Y.; Klehr, J.; Sakai, N.; Ward, T. R.; Matile, S. “Anion-π Catalysis: Bicyclic Products with Four Contiguous Stereogenic Centers from Otherwise Elusive Diastereospecific Domino Reactions on π-Acidic Surfaces” Chem. Sci. 2017, 8, 3770-3774 Macchione, M.; Chuard, N.; Sakai, N.; Matile, S. “Planarizable Push-Pull Probes: Overtwisted Flipper Mechanophores” ChemPlusChem 2017, 82, 1062-1066 Chuard, N.; Gasparini, G.; Moreau, D.; Lörcher, S.; Palivan, C.; Meier, W.; Sakai, N.; Matile, S. “Strain-Promoted Thiol-Mediated Cellular Uptake of Giant Substrates: Liposomes and Polymersomes” Angew. Chem. Int. Ed. 2017, 56, 2947-2950 Morelli, P.; Matile, S. “Sidechain Engineering in Cell-Penetrating Poly(disulfide)s” Helv. Chim. Acta 2017, 100, e1600370 Benz, S.; López-Andarias, J.; Mareda, J.; Sakai, N.; Matile, S. “Catalysis with Chalcogen Bonds” Angew. Chem. Int. Ed. 2017, 56, 812-815 Abegg, D.; Gasparini, G.; Hoch, D.; Shuster, A.; Bartolami, E.; Matile, S.; Adibekian, A. “Strained Cyclic Disulfides Enable Cellular Uptake by Reacting with the Transferrin Receptor” J. Am. Chem. Soc. 2017, 139, 231-238 Liu, L.; Matile, S. “Anion-π Transaminase Mimics” Supramol. Chem. 2017, 29, 702-706 Verolet, Q.; Dal Molin, M.; Colom, A.; Roux, A.; Guénée, L.; Sakai, N.; Matile, S. “Twisted Push-Pull Probes with Turn-On Sulfide Donors” Helv. Chim. Acta 2017, 100, e1600328 Soleimanpour, S.; Colom, A.; Derivery, E.; Gonzalez-Gaitan, M.; Roux, A.; Sakai, N.; Matile, S. “Headgroup Engineering in Mechanosensitive Membrane Probes” Chem. Commun. 2016, 52, 14450-14453 Wang, C.; Miros, F. N.; Mareda, J.; Sakai, N.; Matile, S. “Asymmetric Anion-π Catalysis on Perylenediimides” Angew. Chem. Int. Ed. 2016, 55, 14422-14426 Chuard, N.; Fujisawa, K.; Morelli, P.; Saarbach, J.; Winssinger, N.; Metrangolo, P.; Resnati, G.; Sakai, N.; Matile, S. “Activation of Cell-Penetrating Peptides with Ionpair-π Interactions and Fluorophiles” J. Am. Chem. Soc. 2016, 138, 11264-11271 Benz, S.; Macchione, M.; Verolet, Q.; Mareda, J.; Sakai, N.; Matile, S. “Anion Transport with Chalcogen Bonds” J. Am. Chem. Soc. 2016, 138, 9093-9096