Zhang, Ge - 香港浸会大学

个人简介

Academic qualifications: 1990-1995: B. Med. Shanghai University of Chinese Medicine, Shanghai, China 1997-2000: M. Med. Institute of Orthopaedics & Traumatology, Shanghai University of Chinese Medicine, China 2000-2003: M.D. Institute of Orthopaedics & Traumatology, Shanghai University of Chinese Medicine, and Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong Previous academic positions held: 1995-2000: Resident, Institute of Orthopaedics & Traumatology, Shanghai University of Chinese Medicine 2000-2003: Physician-in-Charge, Institute of Orthopaedics & Traumatology, Shanghai University of Chinese Medicine 2003-2007 Postdoctoral Research Fellow, Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong 2007-2012 Research Assistant Professor, Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong Present academic position: 2012- Associate Professor, Institute for Advancing Translational Medicine in Bone & Joint Diseases, Hong Kong Baptist University Previous relevant research work: Technical expertise: Bone bioimaging, Bone biology, Bone biomechanics, Bone histomorphometry Research area: RNAi-based or phytotherapy-based translational research in osteoporosis, osteonecrosis, facture repair and arthritis

研究领域

Dr. Ge Zhang's Lab has an interest in understanding molecular mechanisms of musculoskeletal disorders, including osteoporosis, osteoarthritis, osteonecrosis, aged fracture repair and rheumatoid arthritis. Especially, the following histopathological events involved in the above disorders are the lab's recent research focus, i.e. reduction in bone formation during aging in osteoporosis, insufficient cartilage anabolism during cartilage degeneration in osteoarthritis, inadequate bone repair in osteonecrosis, impaired bone healing in aged bone and failure of anabolic repair for bone erosion in rheumatoid arthritis. A series of dysregulated molecules from clinical specimens recruited by the lab (Figure 1 and Figure 2) (Songlin Peng et al. Submitted to ORS 2013) would be identified as potential molecular targets toward translational medicine for preventing and even reversing those histopathological events.

近期论文

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Zhang G (Corresponding Author), Guo BS, Wu H, Tang T, Zhang BT, et al. A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy. Nature Medicine 2012;18:307-14 Xie Xinhui , Wang Xinluan, He Yixin, Liu Zhong, Zhang G(Corresponding Author), Qin Ling (Corresponding Author). Implantation of cryopreserved bone marrow mononuclear cell to promote bone repair within steroid-associated osteonecrotic lesion in a rabbit model. Arthritis & Rheumatism 2012; 64:1562-71 HE Yi-Xin, Liu Zhong, Pan Xiao-Hua, Tang Tao, Guo Bao-Sheng, Zheng Li-zhen, Xie Xin-Hui, Wang Xin-Luan, Lee Kwong-Man, Li Gang, Cao Yong-Ping, Wei Leif, Chen Yang, Hung Leung-Kim, Qin Ling, Zhang G (Corresponding Author). Deletion of estrogen receptor beta accelerates early stage of bone healing in a mouse osteotomy model. Osteoporosis Int. 2011; 23: 377-89 Berry He, Zhang G (Corresponding Author), Liu Zhong, et al. Impaired bone healing pattern in mice with ovariectomy-induced osteoporosis: A drill-hole defect model. Bone 2011; 48:1388-400 Zhang G, Sheng H, He YX, et al. Continuous occurrence of both insufficient neovascularization and elevated vascular permeability during inadequate repair of steroid-associated osteonecrotic lesions. Arthritis & Rheumatism 2009 ;60: 2966-77 Zhang G, Qin L, Shi Y. Epimedium-Derived Phytoestrogen Flavonoids Exert Beneficial Effect on Preventing Bone Loss in Late Postmenopausal Women: A 24-Month Randomized, Double-Blind and Placebo-Controlled Trial. Journal of Bone and Mineral Research 2007; 22: 1072-1079 Zhang G, Qin L, Hung WY, et al. Flavonoids Derived from Herbal Epimedium Brevicornum Maxim. Prevent OVX-induced Osteoporosis in Rats Independent of Its Enhancement in Intestinal Calcium Absorption. Bone 2006; 38: 818-825