Cui, Xin - Mississippi State University

个人简介

EDUCATION AND EMPLOYMENTS 08/2016-present Assistant Professor Department of Chemistry, Mississippi State University 08/2015-08/2016 Assistant Professor Department of Natural Science, Baruch College at the City University of New York 08/2012-08/2015 Research Assistant Professor Department of Chemistry, University of South Florida 09/2008-08/2012 Postdoctoral Associate Advisor: Prof. X. Peter Zhang Department of Chemistry, University of South Florida 09/2003-07/2008 Ph.D.Advisor: Prof. Qing-Xiang Guo, Prof. Lei Liu Department of Chemistry, University of Science and Technology of China 09/1999-07/2003 B.S. Advisor: Prof. Qing-Xiang Guo Department of Chemistry, University of Science and Technology of China HONORS AND AWARDS 2017 MSU CTL Teaching Improvement and Innovation Small Grant 2015 The Professional Staff Congress-City University of New York (PSC-CUNY) Research Award 2012 USF Postdoctoral Scholar Research Grant 2007 “Dong-Gang Scholarship” for Graduate Students, USTC 2006 “Dong-Gang Scholarship” for Graduate Students, USTC

研究领域

Research in our laboratory focuses on organic chemistry, catalysis, and medicinal chemistry. We are particularly interested in exploring new chemical processes that utilize earth-abundant and biocompatible catalysts to construct value-added molecules in a rapid and selective manner. Catalytic processes for rapid formation of multiple chemical bonds Our research efforts are devoted to the revealing of new catalytic reactivity that involves one-step selective formation of multiple carbon-carbon and carbon-heteroatom bonds. Such reactivity would allow for effective construction of complex skeletons and polyfunctionalized molecules. Specifically, we are interested in new multicomponent cyclization systems that utilize simple and noncyclic starting materials for constructing heterocyclic and heteropolycyclic structures. Mechanistic study-guided catalyst design is used as a powerful tool to investigate new pathways for solving some of the long standing problems. Selective functionalization of unsaturated hydrocarbons Further development of new transformations of unsaturated hydrocarbons will always bring exciting opportunities for synthetic chemistry and other applicable areas such as fine chemical, pharmaceutical, and material sciences. In our lab, we are exploring new types of catalytic activation of heterocyclic small rings for selective functionalization of unactivated alkenes and related unsaturated hydrocarbons. Through the development of both transition and main group element-based catalysts, together with ligand design, these catalytic systems are expected to be able to effectively control and switch chemoselectivity and stereoselectivity. The catalytic processes developed in our group are applied for the syntheses of synthetically and pharmaceutically important molecules, agrochemicals, and functional materials.

近期论文

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Zhou, H.; Chaminda Lakmal, H. H.; Baine, M. J.; Valle, U. H.; Xu, X.; Cui, X.* “Catalytic [2 + 2 + 2] cycloaddition with indium(III)-activated formaldimines: a practical and selective access to hexahydropyrimidines and 1,3-diamines from alkenes” Chem. Sci. 2017, 8, 6520. [link] Xu, X.; Wang, Y.; Cui, X.; Wojtas, L.; Zhang, X. P. “Metalloradical Activation of α-Formyldiazoacetates for Catalytic Asymmetric Radical Cyclopropanation of Alkenes” Chem. Sci. 2017, 8, 4347. Wang, Y.; Wen, X.; Cui, X.; Wojtas, L.; Zhang, X. P. “Asymmetric Radical Cyclopropanation of Alkenes with In Situ-Generated Donor-Substituted Diazo Reagents via Co(II)-Based Metalloradical Catalysis” J. Am. Chem. Soc. 2017, 139, 1049. Cui, X.; Xu, X.; Jin, L. M.; Wojtas, L.; Zhang, X. P. “Stereoselective Radical C–H Alkylation with Acceptor/Acceptor-Substituted Diazo Reagents via Co(II)-Based Metalloradical Catalysis”, Chem. Sci. 2015, 6, 1219. Goswami, M.; Lyaskovskyy, V.; Domingos, S.; Buma, W. J.; Woutersen, S.; Troeppner, O.; Ivanović-Burmazović, I.; Lu, H.; Cui, X.; Zhang, X. P.; Reijerse, E.; DeBeer, S.; van Schooneveld, M.; Pfaff, F.; Ray, K.; de Bruin, B. “Characterization of Porphyrin-Co(III)-‘Nitrene Radical’ Species Relevant in Catalytic Nitrene Transfer Reactions”, J. Am. Chem. Soc. 2015, 137, 5468. Subbarayan V; Jin, L. M.; Cui, X.; Zhang, X. P. “Room temperature activation of aryloxysulfonyl azides by [Co(II)(TPP)] for selective radical aziridination of alkenes via metalloradical catalysis”, Tetrahedron Lett. 2015, 56, 3431.