Ran, Chongzhao - Harvard Medical School - Massachusetts General Hospital

个人简介

Chongzhao Ran, Ph.D., is an Associate Professor in Radiology, Massachusetts General Hospital and Harvard Medical School. He received Master Degree in Medicinal Chemistry from China Pharmaceutical University, and Ph.D. in Medicinal Chemistry from Shanghai Institute of Pharmaceutical Industry, China. He did his postdoctoral training at University of Chicago and Harvard Medical School. Dr. Ran’s research focuses on molecular imaging probe and imaging technology development. Recently, his research group has been successfully designed and synthesized smart fluorescent near infrared imaging probes and 2nd generation PET tracers for amyloid beta of Alzheimer’s disease, and NIRF probes and PET tracers for brown adipose tissue. These probes could be useful tools for monitoring the efficacy of drugs for Alzheimer’s disease, diabetes and obesity in preclinical studies and clinical trials.

研究领域

adipose tissue, brown; amyloid beta-peptides; copper; curcumin; deoxyribonucleosides; elementary particles; fluorescent dyes; fluorine compounds; luminescent measurements; molecular probes; polycyclic hydrocarbons, aromatic; quinones; scapula; spectroscopy, near-infrared Development of new generations of Amyloid imaging probe Development of Two-Photon Imaging Probe New Strategy for AD Drug Development. Developing imaging probes and methods for diabetes and obesity Development of new optical imaging technology

近期论文

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Yang J, Yin W, Van R, Yin K, Wang P, Zheng C, Ran K, Zhu B, Zhang C, Kumar M, et al. Turn-on chemiluminescence probes and dual-amplification of signal for detection of amyloid beta species in vivo. Nature Communications. 2020;11. Yang J, Zhu B, Yin W, Han Z, Zheng C, Wang P, Ran C. Differentiating Aβ40 and Aβ42 with a small molecule fluorescence probe. Chemical Science. 2020;11 :5238-5245 Yang J. Half-curcumin analogues as PET imaging probes for Amyloid beta species. Chem Comm. 2019;55 :3630-3633 . Ran C. PET imaging of human brown adipose tissue with TSPO tracer [11C]PBR28. Molecular Imaging & Biology [Internet]. 2018;20 (2) :188-193. Publisher's Version Hege M, Frautschy S, Schubert D, Maher P, Ran C, Moore A, Bacskai BJ, Koronyo-Hamaoui M, Koronyo Y, Martins R, et al. Drug screening: Don't discount all curcumin trial data. Nature [Internet]. 2017;543 :40. Publisher's Version Ran C. Probe development for systemic molecular imaging of Alzheimer’s disease, in World Molecular Imaging Congress, 2016, Sept.11-14. New York ; Working Paper. Chongzhao Ran, Xiaoyin Xu, Scott B. Raymond, Brian J. Ferrara, Krista Neal, Brian J. Bacskai, Zdravka Medarova, Anna Moore, Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits. J. Am. Chem. Soc. 2009,131(42):15257-61. PMCID: PMC278424. Zhang X, Tian Y, Li Z, Tian X, Sun H, Liu H, Moore A, Ran C.*, Design and Synthesis of Curcumin Analogues for in Vivo Fluorescence Imaging and Inhibiting Copper-Induced Cross-Linking of Amyloid Beta Species in Alzheimer's Disease, J. Amer. Chem. Soc., 2013, 135(44):16397-409. PMID: 24116384. Zhang X, Tian Y, Yuan P, Li Y., Yaseen MA, Grutzendler J, Moore A, Ran C.*, A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease, Chem. Commun., 2014, 50(78):11550-3. PMID: 25134928. Xueli Zhang, Yanli Tian, Can Zhang, Xiaoyu Tian, Alana W. Ross, Robert D. Moir, Hongbin Sun, Rudolph E. Tanzi, Anna Moore, and Chongzhao Ran*, Near‐infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer's disease, Proc. Natl. Acad. Sci. USA, 2015, 112(31):9734-9. PMID: 26199414. YangJ, Zhang X, YuanP, YangJ, XuY, GrutzendlerJ, ShaoY, Moore A, Ran C*, Oxalate-curcumin based probe for micro- and macro-imaging of reactive oxygen species in Alzheimer’s disease, Proc. Natl. Acad. Sci. USA, 2017, In press. Zhang X, Tian Y, Yuan P, Li Y., Yaseen MA, Grutzendler J, Moore A, Ran C.*, A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease, Chem. Commun., 2014, 50(78):11550-3. PMID: 25134928. Tian Y, Zhang X, Li Y, Shoup T, Teng X, Elmaleh D, Moore A, Ran C.*, Crown ethers attenuate aggregation of amyloid beta of alzheimer’s disease. Chem. Commun. 2014, 50(99):15792-5. PMID: 25372154. Tian Y, Zhang X, Li Y, Shoup T, Teng X, Elmaleh D, Moore A, Ran C.*, Crown ethers attenuate aggregation of amyloid beta of alzheimer’s disease. Chem. Commun. 2014, 50(99):15792-5. PMID: 25372154 Ran,C., Pantazopoulos, P., Medarova, Z., Moore, A., Synthesis and Testing of Beta-Cell-Specific Streptozotocin-Derived Near-Infrared Imaging Probes, Angewandte Chemie International Edition,2007, 46(47), 8998-9001. PMID: 17957665. Xueli Zhang, Chaincy Kuo, Anna Moore, Chongzhao Ran*, In Vivo Optical Imaging of Interscapular Brown Adipose Tissue with 18F-FDG via Cerenkov Luminescence Imaging, PLOS One, 2013, 8(4):e62007. PMCID: PMC3634850. Xueli Zhang, Chaincy Kuo, Anna Moore, Chongzhao Ran*, Cerenkov luminescence imaging of interscapular brown adipose tissue. J Vis Exp. 2014 Oct 7;(92):e51790. doi: 10.3791/51790. PMID:25349986. Chongzhao Ran, Zhaoda Zhang, Jacob M. Hooker, Anna Moore. In Vivo Photoactivation Without "Light": Use of Cherenkov Radiation to Overcome the Penetration Limit of Light. Mol Imaging Biol. 2012, 14(2): 156-62. PMID: 21538154. Xueli Zhang, Chaincy Kuo, Anna Moore, Chongzhao Ran*, In Vivo Optical Imaging of Interscapular Brown Adipose Tissue with 18F-FDG via Cerenkov Luminescence Imaging, PLOS One, 2013, 8(4):e62007. PMCID: PMC3634850. Xueli Zhang, Chaincy Kuo, Anna Moore, Chongzhao Ran*, Cerenkov luminescence imaging of interscapular brown adipose tissue. J Vis Exp. 2014 Oct 7;(92):e51790. doi: 10.3791/51790. PMID:25349986.