Glorius, Frank - Westfälische Wilhelms-Universität Münster

个人简介

since 08/2007Full Professor for Organic Chemistry at the Westfälische Wilhelms-Universität Münster 2004 - 2007 C3-Professor for Organic Chemistry at the University of Marburg 2001 - 2004 Independent research at the Max-Planck-Institut für Kohlenforschung, Mülheim/Ruhr (Mentor: Prof. A Fürstner) 2000 - 2001 Postdoctoral studies with Prof. D. A. Evans, Harvard University 1997 - 2000 PhD thesis with Prof. A. Pfaltz, University of Basel and Max-Planck-Institut für Kohlenforschung, Mülheim/Ruhr 1996 - 1997 Diploma thesis with Prof. A. Pfaltz and Prof. H. M. R. Hoffmann, Max-Planck-Institut für Kohlenforschung, Mülheim/Ruhr and the University of Hannover 1995 - 1996 Research studies with Prof. P. A. Wender, Stanford University 1992 - 1997 Studies of chemistry at the University of Hannover 1991 - 1992 Military service

研究领域

Catalysis & Function! Life without organic molecules (such as pharmaceuticals, crop-protection, chemical industry, energy supply, materials science, nutrition, fragrances and flavors) would be neither convenient nor possible. Thus, the ability to produce any desired organic compound efficiently is of great interest. In this respect, catalysis is a key technology that will become more and more important in the future. Our research program is dedicated to the development and application of new catalytic methods in the area of organic chemistry in order to facilitate the way organic molecules are made. In addition, we design molecules that exhibit sought-after function in diverse areas such as biology and material science. Thereby, we not only apply rational design, but also develop smart screening strategies and data-driven computational models. Arguably, a unique feature of our group is that we successfully do research in many complementary areas of catalysis. The diversification is advantageous for a sound education of the group members and, in addition, enables modern interdisciplinary research projects also within the group.

近期论文

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L. Schlosser, D. Rana, P. Pflüger, F. Katzenburg, F. Glorius,*EnTdecker – A machine learning-based platform for guiding substrate discovery in energy transfer catalysis,J. Am. Chem. Soc. 2024, 146, 13266-13275. D.-H. Liu,§ P. M. Pflüger,§ A. Outlaw,§ L. Lückemeier, F. Zhang, C. Regan, H. Rashidi Nodeh, T. Cernak,* J. Ma,* F. Glorius,*Late-Stage Saturation of Drug Molecules,J. Am. Chem. Soc. 2024, 146, 11866-11875. F. Strieth-Kalthoff,§ S. Szymkuc,§ K. Molga,§ A. Aspuru-Guzik, F. Glorius,* B. A. Grzybowski,*Artificial Intelligence for Retrosynthetic Planning Needs Both Data and Expert Knowledge,J. Am. Chem. Soc. 2024, 146, 11005-11017. D. Rana, P. M. Pflüger, N. P. Hölter, G. Tan, F. Glorius,Standardizing Substrate Selection: A Strategy toward Unbiased Evaluation of Reaction Generality,ACS Cent. Sci. 2024, 10, 899-906. M. L. Schrader,§ F. R. Schäfer,§ F. Schäfers,§ F. Glorius,Bridging the information gap in organic chemical reactions,Nat. Chem. 2024, 16, 491-498. DOI R. Laskar,§ S. Dutta,§ J. C. Spies, P. Mukherjee, A. Renteria-Gomez, R. E. Thielemann, C. G. Daniliuc, O. Gutierrez,* F. Glorius,*γ-Amino Alcohols via Energy Transfer Enabled Brook Rearrangement,J. Am. Chem. Soc. 2024, 146, 10899-10907. Y. Liang, R. Nematswerani, C. G. Daniliuc, F. Glorius,Silver-Enabled Cycloaddition of Bicyclobutanes with Isocyanides for the Synthesis of Polysubstituted 3-Azabicyclo[3.1.1]heptanes,Angew. Chem. Int. Ed. 2024, 63, e202402730; Angew. Chem. 2024, 136, e202402730. P. M. Pflüger,§ M. Kühnemund,§ F. Katzenburg,§ H. Kuchen, F. Glorius,An evolutionary algorithm for interpretable molecular representations, Chem 2024, 10, 1391-1405. S. Dutta, Y.-L. Lu,§ J. E. Erchinger,§ H. Shao, E. Studer, F. Schäfer, H. Wang, D. Rana, C. G. Daniliuc, K. N. Houk,* F. Glorius,*Double Strain-Release [2π+2σ]-Photocycloaddition,J. Am. Chem. Soc. 2024, 146, 5232-5241. J. Ren,*§ M. Das,§ H. Osthues, M. Nyenhuis, B. Schulze Lammers, E. Kolodzeiski, H. Mönig, S. Amirjalayer,* H. Fuchs,* N. L. Doltsinis,* F. Glorius,*The electron-rich and nucleophilic N-heterocyclic imines on metal surfaces: binding modes and interfacial charge transfer,J. Am. Chem. Soc. 2024, 146, 7288-7294. L. Lückemeier,§ T. De Vos,§ L. Schlichter, C. Gutheil, C. G. Daniliuc, F. Glorius, Chemoselective Heterogeneous Hydrogenation of Sulphur Containing Quinolines Under Mild Conditions,J. Am. Chem. Soc. 2024, 146, 5864-5871. C. Gutheil, G. Ross, S. Amirjalayer, B. Mo, A. H. Schäfer, N. L. Doltsinis, B. Braunschweig,* F. Glorius,*Tailored Monolayers of N-Heterocyclic Carbenes by Kinetic Control,ACS Nano 2024, 18, 3043-3052. S. Dutta,§ D. Lee,§ K. Ozols,§ C. Daniliuc, R. Shintani, F. Glorius,Photoredox-Enabled Dearomative [2π+2σ] Cycloaddition of Phenols,J. Am. Chem. Soc. 2024, 146, 2789-2797. F.-P. Wu, C. C. Chintawar, R. Lalisse, P. Mukherjee, S. Dutta, J. Tyler, C. G. Daniliuc, O. Gutierrez,* F. Glorius,*Ring expansion of indene by photoredox-enabled functionalized carbon-atom insertion,Nat. Catal. 2024, 7, 242-251. S. Dutta, J. E. Erchinger, F. Strieth-Kalthoff, R. Kleinmans, F. Glorius,Energy transfer photocatalysis: exciting modes of reactivity, Chem. Soc. Rev. 2024, 53, 1068-1089. J. Goretzko, I. Pauels, N. Heitzig, K. Thomas, M. Kardell, J. Naß, E. Kleinhans Krogsaeter, S. Schloer, B. Spix, A. L. L. Matos, C. Leser, T. Wegner, F. Glorius, F. Bracher, V. Gerke, J. Rossaint, C. Grimm, U. Rescher,* P-selectin-dependent leukocyte adhesion is governed by endolysosomal two-pore channel 2, Cell Rep. 2023, 42, 113501. M. Das,§ C. Hogan,§ R. Zielinski, M. Kubicki, M. Koy, C. Kosbab, S. Brozzesi, A. Das, M. T. Nehring, V. Balfanz, J. Brühne, M. Dähne, M. Franz,* N. Esser,* F. Glorius,* N-Heterocyclic Olefins on a Silicon Surface, Angew. Chem. Int. Ed. 2023, 62, e202314663; Angew. Chem. 2023, 135, e202314663. H. Wang,§ J. E. Erchinger,§ M. Lenz,§ S. Dutta, C. G. Daniliuc, F. Glorius, syn-Selective Difunctionalization of Bicyclobutanes Enabled by Photoredox-Mediated C–S σ-Bond Scission, J. Am. Chem. Soc. 2023, 145, 23771-23780. T. Wegner,§ A. Dombovski,§ K. Gesing, A. Köhrer, M. Elinkmann, U. Karst, F. Glorius* J. Jose,* Combining lipid-mimicking-enabled transition metal and enzyme-mediated catalysis at the cell surface of E. coli, Chem. Sci. 2023, 14, 11896-11906. F. Paulus, C. Stein, C. Heusel, T. J. Stoffels, C. G. Daniliuc, F. Glorius, Three-Component Photochemical 1,2,5-Trifunctionalizations of Alkenes towards Densely Functionalized Lynchpins, J. Am. Chem. Soc. 2023, 145, 23814-23823. F. Buß, M. Das, D. Janssen-Müller, A. Sietmann, A. Das, L. F. B. Wilm, M. Freitag, M. Seidl, F. Glorius* F. Dielmann*, Photoswitchable Electron-rich Phosphines: Using Light to Modulate the Electron-Donating Ability of Phosphines, Chem. Commun. 2023, 59, 12019-12022. P. Bellotti,* F. Glorius,* Strain-Release Photocatalysis, J. Am. Chem. Soc. 2023, 145, 20716-20732. J. Ren, M. Koy, H. Osthues, B. Schulze Lammers, C. Gutheil, M. Nyenhuis, Q. Zheng, Y. Xiao, L. Huang, A. Nalop, Q. Dai, H.-J. Gao,* H. Mönig,* N. L. Doltsinis,* H. Fuchs,* F. Glorius,* On-surface synthesis of ballbot-type N-heterocyclic carbene polymers, Nat. Chem. 2023, 15, 1737-1744. L. Quach, E. Adhitama,§ V. Göldner,§ A. Das, F. Demelash, M. Winter,* U. Karst,* T. Placke,* F. Glorius,* Molecular Design of Film-Forming Additives for Lithium-Ion Batteries – Impact of Molecular Substrate Parameters on Cell Performance, ACS Appl. Energy Mater. 2023, 6, 9837-9850. M. Das, M. Kohlstädt,* M. Enders, S. Burger, H. S. Sasmal, B. Zimmermann, A. Schäfer, B. J. Tyler, H. F. Arlinghaus, I. Krossing, U. Würfel, F. Glorius,* Surface Modification of ITO with N-Heterocyclic Carbene Precursors Results in Electron Selective Contacts in Organic Photovoltaic Devices, Chem. Eur. J. 2023, 29, e202301482. V. Göldner, L. Quach, E. Adhitama, A. Behrens, L. Junk, M. Winter, T. Placke, F. Glorius, U. Karst,* Laser desorption/ionization-mass spectrometry for the analysis of interphases in lithium ion batteries, iScience 2023, 26, 107517. F. Bosse, C. Gutheil, D. T. Nguyen, M. Freitag, M. Das, B. J. Tyler, T. Adolphs, A. H. Schäfer, H. F. Arlinghaus, F. Glorius,* B. J. Ravoo,* Selective Removal of Gold: N-Heterocyclic Carbenes as Positive Etch Resists on Planar Gold Surfaces, ACS Appl. Mater. Interfaces 2023, 15, 36831-36838. H. Wang, H. Shao,§ A. Das,§ S. Dutta, H. T. Chan, C. Daniliuc, K. N. Houk,* F. Glorius,* Dearomative ring expansion of thiophenes by bicyclobutane insertion, Science 2023, 381, 75-81. L. Lückemeier,§ M. Pierau,§ F. Glorius, Asymmetric arene hydrogenation: towards sustainability and application, Chem. Soc. Rev. 2023, 52, 4996-5012. F. Zhang, H. S. Sasmal, C. G. Daniliuc, F. Glorius, Ru-NHC-Catalyzed Asymmetric, Complete Hydrogenation of Indoles and Benzofurans: One Catalyst with Dual Function, J. Am. Chem. Soc. 2023, 145, 15695-15701. Y. Liang, F. Paulus, C. G. Daniliuc, F. Glorius, Catalytic Formal [2π+2σ] Cycloaddition of Aldehydes with Bicyclobutanes: Expedient Access to Polysubstituted 2-Oxabicyclo[2.1.1]hexanes, Angew. Chem. Int. Ed. 2023, 62, e202305043; Angew. Chem. 2023, 135, e202305043. J. L. Tyler,§ F. Katzenburg,§ F. Glorius, A focus on sustainable method development for greener synthesis, Chem. Sci. 2023, 14, 7408-7410. H. Wang, Z. Liu, A. Das, P. Bellotti, S. Megow, F. Temps,* X. Qi,* F. Glorius,* Radical thioesterification via nickel-catalyzed sensitized electron transfer, Nature Synth. 2023, 2, 1116-1126. T. Wegner,§ A. L. L. Matos,§ K. Porte,§ K. Mehring,§ M. Pierau,§ H. Horstmeier, V. Gerke,* F. Glorius,*A bifunctional imidazolium-based cholesterol analog for the tracking of cellular cholesterol distributions and cholesterol–protein interactions,Org. Biomol. Chem. 2023, 21, 4817-4822 Y. Lee,§ X. Liu,§ Y. Tong,§ J. L. Childs-Disney,§ B. M. Suresh, R. I. Benhamou, C. Yang, W. Li, M. G. Costales, H. S. Haniff, S. Sievers, D. Abegg, T. Wegner, T. O. Paulisch, E. Lekah, M. Grefe, G. Crynenf, M. Van Meter, J. L. Cleveland, A. Adibekian, F. Glorius,*, H. Waldmann,* M. D. Disney*,Programming inactive RNA-binding small molecules into bioactive degraders,Nature 2023, 618, 169-179. R. Kleinmans,§ S. Dutta,§ K. Ozols, H. Shao, F. Schäfer, R. E. Thielemann, H. T. Chan, C. G. Daniliuc, K. N. Houk,* F. Glorius,*ortho-Selective Dearomative [2π + 2σ]-Photocycloadditions of Bicyclic Aza-Arenes,J. Am. Chem. Soc. 2023, 145, 12324-12332.DOI R. Zielinski, M. Das, C. Kosbab, M. T. Nehring, M. Dähne, N. Esser,* M. Franz*, F. Glorius,*Influence of the defect density on the ordering of an NHC monolayer on a silicon surface,J. Mater. Chem. C 2023, 11, 7377-7382. Y. Zheng,§ T. Wegner,§ D. Di Iorio, M. Pierau, F. Glorius,* S. V. Wegner,*NTA-Cholesterol Analogue for the Nongenetic Liquid-Ordered Phase-Specific Functionalization of Lipid Membranes with Proteins,ACS Chem. Biol. 2023, 18, 1435-1443. G. Tan,§ F. Paulus,§ A. Petti, M.-A. Wiethoff, A. Lauer, C. Daniliuc, F. Glorius,Metal-free photosensitized radical relay 1,4-carboimination across two distinct olefins,Chem. Sci. 2023, 14, 2447-2454. A. Kaithal, H. Sekhar Sasmal, S. Dutta, F. Schäfer, L. Schlichter, F. Glorius,cis-Selective Hydrogenation of Aryl Germanes: A Direct Approach to Access Saturated Carbo- and Heterocyclic Germanes,J. Am. Chem. Soc. 2023, 145, 4109-4118. M. Dellin, I. Rohrbeck, P. Asrani, J. A. Schreiber, N. Ritter, F. Glorius, B. Wünsch, T. Budde, L. Temme, T. Strünker, B. Stallmeyer, F. Tüttelmann, S. G. Meuth, M. Spehr, J. Matschke, A. Steinbicker, C. Gatsogiannis, R. Stoll, N. Strutz-Seebohm, G. Seebohm,The second PI(3,5)P2 binding site in the S0 helix of KCNQ1 stabilizes PIP2-at the primary PI1 site with potential consequences on intermediate-to-open state transition,Biol. Chem. 2023, 404, 241-254. P. Bellotti,§ H.-M. Huang*,§ T. Faber, F. Glorius*,Photocatalytic Late-Stage C–H Functionalization,Chem. Rev. 2023, 123, 4237-4352. J. E. Erchinger, R. Hoogesteger,§ R. Laskar,§ S. Dutta, C. Hümpel, D. Rana, C. G. Daniliuc, F. Glorius,EnT-Mediated N–S Bond Homolysis of a Bifunctional Reagent Leading to Aliphatic Sulfonyl Fluorides,J. Am. Chem. Soc. 2023, 145, 2364-2374. G. Tan, F. Glorius,Stereochemical Editing,Angew. Chem. Int. Ed. 2023, 62 (11), e202217840; Angew. Chem. 2023, 135 (11), e202217840. S. Ikemoto, S. Muratsugu,* T. Koitaya, Y. Tsuj, M. Das, K. Yoshizawa, F. Glorius, M. Tada,*Coordination-Induced Trigger for Activity: N‑Heterocyclic Carbene-Decorated Ceria Catalysts Incorporating Cr and Rh with Activity Induction by Surface Adsorption Site Control,J. Am. Chem. Soc. 2023, 145, 1497-1504. G. Tan, M. Das, R. Kleinmans, F. Katzenburg, C. Daniliuc, F. Glorius,Energy Transfer-Enabled Unsymmetrical Diamination Using Bifunctional Nitrogen-Radical Precursors,Nat. Catal. 2022, 5, 1120-1130 G. Tan, F. Paulus, Á. Rentería-Gómez,§ R. F. Lalisse,§ C. G. Daniliuc, O. Gutierrez*, F. Glorius*,Highly Selective Radical Relay 1,4-Oxyimination of Two Electronically Differentiated Olefins,J. Am. Chem. Soc. 2022, 144, 21664-21673. Y. Liang, R. Kleinmans, C. G. Daniliuc, F. Glorius,Synthesis of Polysubstituted 2-Oxabicyclo[2.1.1]hexanes via Visible-Light-Induced Energy Transfer,J. Am. Chem. Soc. 2022, 144, 20207-20213. D. A. Evans , J. J. Beiger*, J. D. Burch, P. H. Fuller, F. Glorius, E. Kattnig, D. A. Thaisrivongs, W. C. Trenkle, J. M. Young, J. Zhang,Total Synthesis of Aflastatin A,J. Am. Chem. Soc. 2022, 144, 19953-19972. J. J. Navarro, M. Das, S. Tosoni*, F. Landwehr, M. Heyde*, G. Pacchioni, F. Glorius*, B. Roldan Cuenya,Promoted Thermal Reduction of Copper Oxide Surfaces by N-Heterocyclic Carbenes,J. Phys. Chem. C 2022, 126, 17528-17535. S. Dutta,§ J. E. Erchinger,§ F. Schäfers, A. Das, C. G Daniliuc, F. Glorius,Chromium/Photoredox Dual-Catalyzed Synthesis of α-Benzylic Alcohols, Isochromanones, 1,2-Oxy Alcohols and 1,2-Thio Alcohols,Angew. Chem. Int. Ed. 2022, 61, e202212136. F. Schäfers,§ S. Dutta,§ R. Kleinmans, C. Mück-Lichtenfeld, F. Glorius,Asymmetric Addition of Allylsilanes to Aldehydes – A Cr/Photoredox Dual Catalytic Approach Complementing the Hosomi–Sakurai Reaction,ACS Catal. 2022, 12, 12281-12290. T. Wegner, R. Laskar, F. Glorius,Lipid mimetics: A versatile toolbox for lipid biology and beyond,Curr. Opin. Chem. Biol. 2022, 71, 102209. R. Guo, S. Adak, P. Bellotti, X. Gao, W. W. Smith, S. N. Le, J. Ma, K. N. Houk*, F. Glorius*, S. Chen*, M. K. Brown*,Photochemical Dearomative Cycloadditions of Quinolines and Alkenes: Scope and Mechanism Studies,J. Am. Chem. Soc. 2022, 144, 17680-17691. J. J. Navarro, M. Das, S. Tosoni*, F. Landwehr, J. P. Bruce, M. Heyde*, G. Pacchioni, F. Glorius*, B. Roldan Cuenya,Covalent Adsorption of N-Heterocyclic Carbenes on a Copper Oxide Surface,J. Am. Chem. Soc. 2022, 144, 16267-16271. T. Wegner,§ R. Elias,§ L. Roling, N. Raj, V. Gerke, M. Fridman*, F. Glorius*,Cationic, steroid-based imidazolium amphiphiles show tunable backbone-dependent membrane selectivity in fungi,ACS Infect. Dis.2022, 8, 1815-1822. P. Bellotti,§ T. Rogge,§ F. Paulus,§ R. Laskar, N. Rendel, J. Ma, K. N. Houk*, F. Glorius*,Visible-Light Photocatalyzed peri-(3 + 2) Cycloadditions of Quinolines,J. Am. Chem. Soc. 2022, 144, 15662-15671. R. J. Lewis,§ M. Koy,§ M. Macino, M. Das, J. H. Carter, D. J. Morgan, T. E. Davies, J. B. Ernst, S. J. Freakley, F. Glorius*, G. J. Hutchings*,N-Heterocyclic Carbene Modified Palladium Catalysts for the Direct Synthesis of Hydrogen Peroxide,J. Am. Chem. Soc. 2022, 144, 15431-15436. M. Korff, T. O. Paulisch, F. Glorius, N. L. Doltsinis, B. Wünsch*,Photocatalytic Isomerization of (E)-Anethole to (Z)-Anethole,Molecules 2022, 27, 5342. G. Tan, M. Das, H. Keum, P. Bellotti, C. Daniliuc, F. Glorius,Photochemical single-step synthesis of β-amino acid derivatives from alkenes and (hetero)arenes,Nature Chem. 2022, 14, 1174-1184. P. Bellotti,§ H.-M. Huang,§ T. Faber, R. Laskar, F. Glorius,Catalytic Defluorinative Ketyl-Olefin Coupling by Halogen-Atom Transfer,Chem. Sci. 2022, 13, 7855-7862. T. Wagener, M. Pierau, A. Heusler, F. Glorius,Synthesis of Saturated N-Heterocycles via a Catalytic Hydrogenation Cascade,Adv. Synth. Catal. 2022, 364, 3366-3371. H.-M. Huang,§* P. Bellotti,§ S. Kim, X. Zhang, F. Glorius,*Catalytic multicomponent reaction involving a ketyl-type radical,Nature Synth. 2022, 1, 464-474. J. Ma,§ S. Chen,§ P. Bellotti,§ T. Wagener, C. Daniliuc, K. N. Houk,* F. Glorius,*Facile access to fused 2D/3D rings via intermolecular cascade dearomative [2+2] cycloaddition/rearrangement reactions of quinolines with alkenes,Nature Catal. 2022, 5, 405-413. A. Kaithal, T. Wagener, P. Bellotti, C. G. Daniliuc, L. Schlichter, F. Glorius,Access to Unexplored 3D Chemical Space: cis-Selective AreneHydrogenation for the Synthesis of Saturated Cyclic Boronic Acids,Angew. Chem. Int. Ed. 2022, 61(32), e202206687; Angew. Chem. 2022, 134 (32), e202206687.