Nahirney, Patrick - University of Victoria - Division of Medical Sciences

个人简介

Dr. Patrick Nahirney is an Associate Professor of Anatomy and Histology in the Division of Medical Sciences. He teaches human gross anatomy and histology to first and second year undergraduate medical students in the Island Medical Program and conducts research on neurogenesis and neuromuscular disease. He has a particular interest in providing a structural and molecular framework that relates to a number of human diseases including Alzheimer's disease, stress-induced memory loss, Nemaline myopathy, Duchenne muscular dystrophy as well as the development of novel strategies for muscle and nerve tissue engineering and regeneration of injured tissues.

研究领域

"The goal is to understand how stressors and neurological diseases impact learning and memory processes." Synapses in the brain play key roles in neuronal communication and altered synaptic function is believed to underlie a number of neurological disorders. It has long been known that the hippocampus plays a role in learning and memory – it has become of extreme interest since changes in pyramidal, granule, interneuronal and glial cells occur in response to stressors, diseases and experimental treatments, and correspond to changes in spatial learning and memory. Surprisingly, however, data is lacking on the specific subcellular structure of synapses in the hippocampus, and the changes that occur at the level of the synapse to various stressors and treatments. This research examines how maternal stress and ethanol affect in utero and postnatal development of synapses in the hippocampus. Clinical evidence in humans suggests a strong link between prenatal stress and childhood disorders such as autism, fetal alcohol syndrome and schizophrenia. To further these studies, my research will also test how exercise can reverse the effects caused by these stressors during postnatal life. Data from this research will shed new light on how prenatal stress affects synapses made by hippocampal neurons and will provide a testable model system to ascertain the effectiveness of treatments for these neurological disorders. Shown above is a high magnification transmission electron micrograph of a branched spine making two synaptic contacts (*) with presynaptic terminals. The spine and dendrite of the postsynaptic granule cell neuron have been pseudocolored red. Vesicles containing neurotransmitters fill the presynaptic terminals. x50000. Mito: mitochondria, MT: microtubule, Pre: Presynaptic terminal, SER: Smooth endoplasmic reticulum

近期论文

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Nahirney, P.C., P. Reeson and C. E. Brown 2016 Ultrastructural analysis of blood-brain barrier breakdown in the peri-infarct zone in young adult and aged mice. Journal of Cerebral Blood Flow and Metabolism, 36(2): 413-25. PUBMED. Reeson, P., K. Tennant, K. Gerrow, J. Wang, S. Novak, K. Thompson, K. Lockheart, A. Holmes, P.C. Nahirney and C.E. Brown 2015 Delayed inhibition of VEGF signaling after stroke attenuates blood-brain barrier breakdown and improves functional recovery in a comorbidity-dependent manner. Journal of Neuroscience, Apr 1; 35(13):5128-43 (cover image). PUBMED Lindsay, F.J., A.R. Patten, B.R. Christie and P.C. Nahirney 2014 Prenatal ethanol exposure reduces pyramidal cell size and postsynaptic density length in the CA1 region of the hippocampus in adolescent rats. FASEB Journal. Vol 21;726.2. Novak, S.W., M. Vetrici, C.R. King, J. Boots, B.R. Christie and P.C. Nahirney 2013 Developmental changes to dentate gyrus PSD-95 expression and dendritic spine ultrastructure in a mouse model of Fragile X Syndrome. Society of Neuroscience Vol. 43. Nahirney, P.C., P. Reeson, C.E. Brown 2013 Ultrastructral analysis of neurons, glia and capillaries in the peri-infarct zone of an ischemic stroke. FASEB J. Vol 20; 533.15. Brown, C.E., D. Sweetnam, M. Beange, P.C. Nahirney and R. Nashmi 2012 α4* nicotinic acetylcholine receptors modulate experience-based cortical depression in the adult mouse somatosensory cortex. Journal of Neuroscience, 32(4): 1207-19. PUBMED Samson J., I. Piscopo, A. Yampolski, P.C. Nahirney, A. Parpas, A. Aggarwal, R. Saleh and C.M. Drain 2011 fabrication of size-tunable metallic nanoparticles using plasmid DNA as a biomolecular reactor. Nanomaterials, 1(1):64-78. Samson J., P.C. Nahirney, D.M. Drain and I. Piscopo 2011 Simplifying electron diffraction pattern identification of mixed-material nanoparticles. Microscopy Today, 19:38-41 Nowak, S.J., P.C. Nahirney, K. Hadjantonakis and M.K. Baylies. 2009 Live imaging reveals actin cytoskeleton remodeling is essential for mammalian myoblast fusion. Journal of Cell Science, 122: 3282-93. PUBMED Samson, J., A. Varotto, P.C. Nahirney, A. Toschi, I. Piscopo and C.M. Drain. 2009 Fabrication of metal nanoparticles using toroidal plasmid DNA as a sacrificial mold. ACS Nano, 3(2): 339-344. PUBMED Nahirney, P.C., J.G. Forbes, H.D. Morris, S.C. Chock and K. Wang. 2006 What the buzz was all about: Superfast song muscles rattle the tymbals of male cicadas. FASEB Journal, 20:2017-26. PUBMED Nahirney, P.C., D.A. Fischman and K. Wang 2006 Myosin flares and actin leptomeres as myofibril assembly/disassembly intermediates in sonic muscle fibers. Cell and Tissue Research, 324: 127-138. PUBMED Xaymardan, M.,L. Tang, L. Zagreda, B. Pallante, J. Zheng, J.L. Chazen, A. Chin, I. Duignan, P. Nahirney, S. Rafii, T. Mikawa and J.M. Edelberg 2004 Platelet-derived growth factor-AB promotes the generation of adult bone marrow-derived cardiac myocytes. Circulation Research, 94: e39-e45. PUBMED Lewis, M.K., P.C. Nahirney, V. Chen, B.B. Adhikari, J. Wright, M.K. Reedy, A.H. Bass and K. Wang 2003 Concentric intermediate filament lattice links to specialized Z-band junctional complexes in sonic muscle fibers of the type I male midshipman fish. Journal of Structural Biology, 143(1): 56-71. Cover illustration. PUBMED Nahirney, P.C., T. Mikawa and D.A. Fischman 2003 Evidence for an extracellular matrix bridge guiding proepicardial cell migration to the myocardium of chick embryos. Developmental Dynamics, 227: 511-523. Cover illustration. PUBMED *Zippin, J.H., Y. *Chen, *P. Nahirney, M. Kamenetsky, M.S. Wuttke, D.A. Fischman, L.R. Levin, and J. Buck 2003 Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains. FASEB Journal, 17: 82-84. Cover illustration. *First three authors contributed equally. PUBMED Klimuk S.K., S.C. Semple, P.C. Nahirney, M.C. Mullen, C.F. Bennett, P. Scherrer and M.J. Hope 2000 Enhanced anti-inflammatory activity of a liposomal intercellular adhesion molecule-1 antisense oligodeoxynucleotide in an acute model of contact hypersensitivity. Journal of Pharmacology and Experimental Therapeutics, 292: 480-488. PUBMED Jiang X., T. Kobayashi, P.C. Nahirney, E. Garcia del Saz and H. Seguchi 2000 Ultracytochemical study on the localization of superoxide producing sites in stimulated rat neutrophils. Anatomical Record, 258: 156-165. PUBMED Ovalle, W.K., P.R. Dow and P.C. Nahirney 1999 Structure, distribution, and innervation of muscle spindles in avian fast and slow skeletal muscle. Journal of Anatomy, 194: 381-394. PUBMED Ovalle, W.K., S.L. Shinn and P.C. Nahirney 1998 Ultrastructure of the larval tentacle and its skeletal muscle in Xenopus laevis. Tissue & Cell, 30: 216-225. PUBMED Jiang, X., T. Kobayashi, P.C. Nahirney, E. Garcia del Saz and H. Seguchi 1998 An ultracytochemical study on the dynamics of alkaline phosphatase-positive granules in rat neutrophils. Histology and Histopathology, 13: 57-65. Kamada, M., T. Kobayashi, P.C. Nahirney, T. Okada, E. Garcia del Saz, T. Shuin and H. Seguchi 1997 Actin and cytokeratin in superficial transitional epithelial cells of the rabbit urinary bladder: A confocal and electron microscopic study. Acta Histochemica et Cytochemica, 30: 29-36. PUBMED Nahirney, P.C., P.R. Dow and W.K. Ovalle 1997 Quantitative morphology of mast cells in skeletal muscle of normal and genetically-dystrophic mice. Anatomical Record, 247: 341-349. PUBMED Jiang, X., T. Kobayashi, P.C. Nahirney, E. Garcia del Saz and H. Seguchi 1996 Ultracytochemical localization of alkaline phosphatase (ALPase) activity in neutrophils of the rat lung following injection of lipopolysaccharide. Acta Anatomica Nipponica, 71: 183-194. PUBMED Nahirney, P.C. and W.K. Ovalle 1993 Distribution of dystrophin and neurofilament protein in muscle spindles of normal and mdx-dystrophic mice: An immunocytochemical study. Anatomical Record, 235: 501-510. PUBMED