Gorrell, Andrea - University of Northern British Columbia

个人简介

Educational Background BSc in Biochemistry, with honors - Texas A&M University, 1991 PhD in Biochemistry - Iowa State University, 2000 Postdoctoral work at Pennsylvania State University, J.G. Ferry 2000-2003 Involved with: Ribowest Scientists and Innovators in the Schools Quantum Leaps (Co-chair with Dr. Margot Mandy)

研究领域

Protein structure and function; interest in the methanogenic pathways of the archaea

近期论文

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Kim SE, Gorrell A, Rader SD, Lee CH. Endoribonuclease activity of human apurinic/apyrimidinic endonuclease 1 revealed by a real-time fluorometric assay. Anal Biochem. 2010 Mar 1;398(1):69-75. PMID: 19932678 Gorrell A, Ferry JG. Investigation of the Methanosarcina thermophila acetate kinase mechanism by fluorescence quenching. Biochemistry. 2007 Dec 11;46(49):14170-6. Epub 2007 Nov 14. PMID: 17999468 Ingram-Smith C, Gorrell A, Lawrence SH, Iyer P, Smith K, Ferry JG. Characterization of the acetate binding pocket in the Methanosarcina thermophila acetate kinase. J Bacteriol. 2005 Apr;187(7):2386-94. Erratum in: J Bacteriol. 2005 Jul;187(14):5059. PMID: 15774882 Gorrell A, Lawrence SH, Ferry JG. Structural and kinetic analyses of arginine residues in the active site of the acetate kinase from Methanosarcina thermophila. J Biol Chem. 2005 Mar 18;280(11):10731-42. Epub 2005 Jan 12. PMID: 15647264 Miles RD, Gorrell A, Ferry JG. Evidence for a transition state analog, MgADP-aluminum fluoride-acetate, in acetate kinase from Methanosarcina thermophila. J Biol Chem. 2002 Jun 21;277(25):22547-52. Epub 2002 Apr 17. PMID: 11960978 Gorrell A, Wang W, Underbakke E, Hou Z, Honzatko RB, Fromm HJ. Determinants of L-aspartate and IMP recognition in Escherichia coli adenylosuccinate synthetase. J Biol Chem. 2002 Mar 15;277(11):8817-21. Epub 2002 Jan 7.PMID: 11781326 Lee P, Gorrell A, Fromm HJ, Colman RF. 8-(4-Bromo-2,3-dioxobutylthio)guanosine 5'-triphosphate: a new affinity label for purine nucleotide sites in proteins. Arch Biochem Biophys. 1999 Dec 1;372(1):205-13. PMID: 10562435 Lee P, Gorrell A, Fromm HJ, Colman RF. Implication of arginine-131 and arginine-303 in the substrate site of adenylosuccinate synthetase of Escherichia coli by affinity labeling with 6-(4-bromo-2,3-dioxobutyl)thioadenosine 5'-monophosphate. Biochemistry. 1999 May 4;38(18):5754-63. PMID: 10231526 Wang W, Gorrell A, Hou Z, Honzatko RB, Fromm HJ.Ambiguities in mapping the active site of a conformationally dynamic enzyme by directed mutation. Role of dynamics in structure-function correlations in Escherichia coli adenylosuccinate synthetase. J Biol Chem. 1998 Jun 26;273(26):16000-4. PMID: 9632649 Kang C, Sun N, Poland BW, Gorrell A, Honzatko RB, Fromm HJ. Residues essential for catalysis and stability of the active site of Escherichia coli adenylosuccinate synthetase as revealed by directed mutation and kinetics. J Biol Chem. 1997 May 2;272(18):11881-5. PMID: 9115248 Wang W, Gorrell A, Honzatko RB, Fromm HJ.A study of Escherichia coli adenylosuccinate synthetase association states and the interface residues of the homodimer. J Biol Chem. 1997 Mar 14;272(11):7078-84. PMID: 9054400