Grigliatti, Thomas - University of British Columbia

个人简介

B.Sc., Santa Clara; M.S., California State (San Francisco); Ph.D., U.B.C.; Member, Nat'l Centres of Excellence Insect Biotec. Lab.; Associate Member, Medical Genetics Dept., U.B.C.; President, Genetics Society of Canada 1993-95 Genes that encode non-histone chromosomal proteins: The modulation of chromatin domains is the first step in the regulation of gene expression in eukaryotes. Yet the assembly of DNA and proteins into active and inactive chromatin, and into chromosomes, is a process about which we know very little. We have isolated mutations in Drosophila that actually alter both chromosome and chromatin structure and consequently also regulate gene expression and developmental switches. Many of these genes are conserved in vertebrates. We are focussing our current work on the molecular analyses of these genes and their products including DNA sequence analysis, cellular and developmental expression of theprotein products, dissecting the hierarchy of gene action and protein interactions in the assembly of chromatin in vivo.

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Clegg, N.S., I.P. Whitehead, J. Williams, M. O'Grady, G.P. Spiegelman & T.A. Grigliatti. 1993. Molecular and developmental analysis of cdc 2 mutations in Drosophila melanogaster. Genome 36:676-685 Meister, G.A. & T.A. Grigliatti. 1993. Rapid spread of a P element/ Pdh Gene construct through populations of Drosophila melangaster. Genome Grigliatti, T.A. 1992. Position-effect Variegation: An Assay for Non-histone Chromosomal Proteins and Chromatin Assembly and Modifying Factors. Functional Organization of the Nucleus Academic Press, Inc. San Diego, CA; pp. pp. 587-627 Henderson, D. & T.A. Grigliatti. 1992. A rapid somatic genotoxicity assay in Drosophila melanogaster using multiple mutant mutagen - sensitivity (mus) strains. Mutagenesis 7: 399-406 Hayashi, S., A. Ruddell, D. Sinclair & T.A. Grigliatti. 1990. Suppressors of position effect variegation alter chromosome and chromatin structure. Chromosoma 99: 391-400 Good, A.G., G. Meister, H. Brock, T.A. Grigliatti & D.A. Hickey. 1989. Rapid spread of transposable P elements in experimental populations of Drosophila melanogaster. Genetics, 112: 387-396 Lansman, R.A., R.O. Shade, T.A. Grigliatti & H.W. Brock. 1987. The evolution of P transposable elements: Sequences of the Drosophila nebulosa P element. Proc. Natl. Acad. Sci., U.S.A. 84: 6491-6495