个人简介

Our work in biomaterials falls in two areas: (1) the characterization of rubber-like proteins, and (2) the mechanical and molecular design of high performance protein polymers. Our research on protein rubbers deals with the physical chemistry and dynamic mechanical properties of these proteins and with the mechanical design of the arterial elastic tissues in which these rubber-like proteins are found. This includes studies on the elastic mechanism of elastin, on the process of vibration-induced fatigue in mammalian arteries, the characterization of elastic proteins and elastic arteries in cephalopod molluscs and marine mammals. Our research with high-performance protein polymers centres on mechanical and molecular design of spider silks, byssal fibres, hagfish slime fibres and horse hoof keratin. Much of our work on locomotion deals with the role of elastic energy storage in the mechanics of jet-propelled swimming in squid and jellyfish. This includes an investigation into the structure and mechanical properties of a collagen fibre-lattice in squid mantle and an analysis of the contribution of stored elastic energy to the animal's propulsive mechanism. We recently completed a study on the swimming mechanics of hydrozoan jellyfish in which we demonstrated that the mesogleal bell is an elastic structure that resonates at a frequency that is essentially identical to the jet frequency. Postdoctoral Fellow, Cambridge Univ. (1970-73); Assistant Professor, U.B.C. (1973-80); Associate Professor, U.B.C. (1980-86); Professor, U.B.C. (1986 - 2008)

研究领域

Comparative Physiology

My research field is comparative biomechanics, concentrating on the design of structural materials in animal skeletons and on the mechanics of locomotion in soft-bodied animals.

近期论文

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Fudge, D., Hillis, S., Levy, N., and Gosline, J.. 2010. Hagfish slime threads as a biomimetic model for high performance protein fibres. Biomimetics & Bioinspiration published online 20/08/2010; 5 - Lillie, M.A., Shadwick, R.E. & Gosline, J.M. 2010. Mechanical anisotropy of inflated elastic tissue from pig aortas. Journal of Biomechanics 43: 2070–2078 Lv, S., Dudek, Daniel M, Cao, Yi, Balamurali, M. M., Gosline, J. M. & Li, Hongbin. 2010. Designed biomaterials to mimic the mechanical properties of muscles. Nature, London 465: 69 – 73 Ortlepp, C. & Gosline, J.M. 2008. The scaling of safety factor in spider draglines. J. Exp. Biol. 211: 2832-2840 Savage, K. N. & Gosline, J.M. 2008. The effect of proline on the network structure of major ampullate silks as inferred from their mechanical and optical properties. J. Exp. Biol. 211: 1937-1947 Savage, K. N. & Gosline, J.M. 2008. The role of proline in the elastic mechanism of hydrated spider silks. J. Exp. Biol. 211: 1948 – 1957 Lillie, M. & Gosline, J.M. 2007. Limits to the durability of elastic tissue, Biomaterials. 28: 2021–2031 Lillie, M. & Gosline, J.M. 2006. Tensile Residual Strains on the Elastic Lamellae along the Porcine Thoracic Aorta. J. Vascular Res. 43:587–601 Lillie, M. & Gosline, J.M. 2006. Mechanical Properties of Elastin along the Thoracic Aorta in the Pig. J. Biomech. 40: 2214–2221 Lim, J., Fudge, D.S., Levy, N. & Gosline, J.M. 2006. Hagfish slime ecomechanics: testing the gill-clogging hypothesis. J. Exp. Biol. 209: 702-710 Fudge, D.S., Levy, N., Chiu, S. & Gosline, J.M. 2005. Composition, morphology and mechanics of hagfish slime. J. Exp. Biol. 208, 4613-4625 Goldbogen, J.A., Shadwick, R.E., Fudge, D.S. and Gosline, J.M. 2005. Fast-start muscle dynamics in the rainbow trout Oncorhynchus mykiss: phase relationship of white muscle shortening and body curvature. J. Exp. Biol. 208: 929-938 Megill, W., Gosline, J.M. & Blake, R.W. 2005. The modulus of elasticity of mesogleal microfibrils from the hydromedusa Polyorchis pennicilatus. J. Exp. Biol. 208: 3819-3834 Ortlepp, C.S. & Gosline, J.M. 2004. Consequences of forced silking. Biomacromolecules 5: 727 - 731 Savage, K, Guerette, P. & Gosline, J.M. 2004. The supercontraction stress in Major Ampullate silks. Biomacromolecules. 5: 675 - 679 Braun, M.H., Brill, R.W., Gosline, J.M. and Jones, D.R. 2003. Form and Function of the Bulbus Arteriosus in Yellowfin Tuna (Thunnus albacares): Dynamic Properties. J. Exp. Biol. 206; 3311-3326 Braun, M.H., Brill, R.W., Gosline, J.M. and Jones, D.R. 2003. Form and Function of the Bulbus Arteriosus in Yellowfin Tuna (Thunnus albacares), Bigeye Tuna (Thunnus obesus) and Blue Marlin (Makaira nigricans): Static Properties. J. Exp. Biol. 206: 3327-3335 Fudge, D, Gardner, K.H., Forsyth, V.T., Riekel, C., and Gosline, J.M.. 2003. The mechanical properties of hydrated intermediate filaments: Insights from hagfish slime threads. Biophysical J 85: 2015-2027 Fudge, D.S. & Gosline, J.M. 2003. Molecular design of the alpha-keratin composite: Insights from a matrix-free model, hagfish slime threads. Proc. Roy. Soc., Lond. B: 271: 291-299 Gosline, J.M., Lillie, M., Carrington, E., Guerette, P., Ortlepp, C. & Savage, K. 2002. Elastic Proteins: Biological roles and mechanical properties. Phil. Trans. Roy. Soc., B, 357: 121-132 Lillie, M.A. & Gosline, J.M. 2002. One-dimensional swelling of elastin. Biopolymers, 64: 115-126 Lillie, M.A. & Gosline, J.M. 2002. Effects of lipids on elastin’s viscoelastsic properties. Biopolymers, 64: 127 - 138 Lillie, M.A. & Gosline, J.M. 2002. The role of viscoelasticity on the strength of arterial elastin. Intern. J. Biol. Macromolecules, 30:119-127 Chalmers, G.W.G., Gosline, J.M. & Lillie, M.A. 1999. The hydrophobicity of vertebrate elastins, J. exp. Biol.,202: 301-314 Gosline, J.M., Guerette, P.A., Ortlepp, C.S. & Savage, K.N. 1999. The mechanical design of spider silks: from fibroin sequence to mechanical function, J. exp. Biol., 202: 3295 - 3303