Milsom, William K - University of British Columbia

个人简介

BSc Hons (University of Alberta); MSc (University of Washington); PhD (University of British Columbia) Work in my lab is directed at determining the physiological basis of biodiversity in vertebrates. What are the physiological adaptations that individual species possess that allow them to live in different environments? In particular we study respiratory, cardiovascular, thermoregulatory and metabolic adaptations for life in environments with low / high levels of oxygen, carbon dioxide, temperature, food and water. We are particularly interested in the neural control of these processes and their function in unanesthetized, freely behaving animals.

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Andrade, D., Corcoran, A., Marshall, L.H. and Milsom, W.K. 2006. Hypothermia-induced respiratory arrest and recovery in hamsters. Respir. Physiol. Neurobiol. (In preparation) Boon, J.A., Antignano, F.L., Stewart, S.L. and Milsom, W.K. 2006. Respiratory chemoreflexes and effects of cortical activation state: role of NMDA-type glutamate receptor mediated processes. (In Preparation) Borg, K.A., Sharam, S. and Milsom, W.K. 2006. Inter- and intra-individual variability in ventilation and respiratory chemosensitivity in stickelback and zebrafish. Physiol. Zool. Biochem. (In preparation) Dodd, G.A.A., Scott, G.R. and Milsom, W.K. 2006. Ventilatory roll off during sustained hypercapnia is gender specific in pekin ducks. Respir. Physiol. Neurobiol. 156:47-60 Florindo, L.H., Leite, C.A.C., Kalinin, A.L., Reid, S.G., Milsom, W.K. and Rantin, F.T. 2006. The role of branchial and orobranchial O2 chemoreceptors in the control of aquatic surface respiration (ASR) in the neotropical fish tambaqui (Colossoma macropomum): Prolonged and acute responses to hypoxia. J.Exp. Biol. 209:1709-1715 Gargaglioni, L., Branco,L.G., and Milsom, W.K. 2006. Modulation of respiratory pattern by midbrain sites in Anuran amphibians. Am. J. Physiol. (In Preparation) Gargaglioni, L.H. and Milsom, W.K. 2006. Control of breathing in anuran amphibians. Comp. Biochem. Physiol. (In Press, accepted June 25th, 2006 (CBA ms.11915 LatAM)) Harris, M.B. and W.K. Milsom. 2006. Vagotomy and disruption of NMDA-type glutamate receptors alters ventilation in hibernating ground squirrels. (In Preparation) Hedrick, M.S., Collidge, E.H., and Milsom, W.K. 2006. Ventilatory Systems. In: Ancient Fishes. Fish Physiology: Vol.27, (Series editors A. P. Farrell and C. J. Brauner; Volume Editors: D.J. McKenzie, A.P (Submitted) Leite, C.A.C., Florindo, L.H., Milsom, W.K. and Rantin, F.T. 2006. Gill chemoreceptors and cardiorespiratory reflexes in the neotropical teleost pacu, Piaractus mesopotamicus. J Exp. Biol. (Submitted) Lumsden, A.L., O’Neill, A.E., and Milsom, W.K. 2006. Chemoreceptors mediating cardioventilatory responses to O2 and CO2 in carp (Cyprinus carpio L). Respir. Physiol. Neurobiol. (In preparation) Marshall, L.H. and Milsom, W.K. 2006. The effects of Riluzole on respiratory rhythm generation in neonatal rodents in vitro. Respir. Physiol. Neurobiol. (In revision) Milsom, W.K., Andrade, D.U., Brito, S.P., Toledo, L.F., Wang,T., and Abe, A.S. 2006. Seasonal changes in daily metabolic patterns of tegu lizards (Tupinambis merianae) placed in the cold (17Â°C) and dark. Physiol. Biochem. Zool. (Re-Submitted) Milsom, W.K., Powell, F.L. and Mitchell, G.S. 2006. Frontiers in comparative physiology II: Respiratory rhythm, pattern and responses to environmental change. Foreward. Respir. Physiol. Neurobiol. 154:1-3 O’Neill, A.E., and Milsom, W.K. 2006. Episodiv breathing in carp: role of the midbrain. Respir. Physiol. Neurobiol. (In preparation). Scott, G.R. and Milsom, W.K. 2006. Flying high: A theoretical analysis of the factors limiting exercise performance in birds at altitude. Respir. Physiol. Neurobiol. 154:284-301 Tattersall, G.J., Andrade, D.V. Brito, S.P., Abe, A.S. and Milsom W.K. 2006. Regulation of ventilation in the caiman, (Caiman crocodylus); Effects of inspired CO2 on pulmonary and upper airway chemoreceptors. J. Comp Physiol. B. 176:125-138 Toledo, L.F., Brito, S.P., Milsom, W.K., Abe, A.S. and Andrade D.V. 2006. Effects of Changes in Season, Temperature and Body Mass on the Standard Metabolic rate of Tegu Lizards (Tupinambis merianae). Physiol. Biochem. Zool. (Re-Submitted) Zimmer, M.B. and W.K. Milsom. 2006. The effect of age and pontine input on respiratory rhythm during hypothermia in rat brainstem-spinal cord preparations. J. Physiol. (London). (In Preparation) Foster, G.E., McKenzie, D.C., Milsom, W.K. and A.W. Sheel. 2005. Effects of two paradigms of intermittent hypoxia on human ventilatory, cardiovascular and cerebral responses to hypoxia. J. Physiol. (London), 567.2:689-699 Lang, C.J., A.D. Postle, S. Orgeig, F. Possmayer, W. Bernhard, A.K. Panda, K.D. Jurgens, W.K. Milsom, K. Nag and C.B. Daniels. 2005. Dipalmitoylphosphatidylcholine is not the major surfactant phospholipid species in all mammals. Am. J. Physiol. 289:R1426-R1439 Reid, S.G., Perry, S.F., Gilmour, K.M., Milsom, W.K. and F.T. Rantin. 2005. Reciprocal modulation of oxygen and carbon dioxide cardiorespiratory chemoreflexes in the tambaqui (Colossoma macropomum). Respir. Physiol. Neurobiol. 146:175-194 Skinner, L. and W.K. Milsom. 2005. Respiratory chemosensitivity during wake and sleep in harbour seal pups (Phoca vitulina richardsii). Physiol. Biochem. Zool. 77: 847-863