Wong, Judy - University of British Columbia - Faculty of Pharmaceutical Sciences

个人简介

Judy Wong is an associate professor in the Faculty of Pharmaceutical Sciences at UBC. She obtained a PhD in pharmacology from the University of Toronto and was a postdoctoral fellow in the Department of Molecular and Cell Biology at the University of California in Berkeley.

研究领域

The Wong laboratory investigates mechanisms responsible for the gross structural maintenance of the genome, the role of telomeres and telomerase in preventing chromosome erosion, and the cellular pathways that respond to DNA damage. Most cancers and premature aging syndromes share an observable loss of genome integrity. Her long-term goal is to discover genetic and pharmacological means to control cellular changes that affect stable genome maintenance.

近期论文

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Structure-function relationship and biogenesis regulation of the human telomerase holoenzyme., Hukezalie, Kyle R., and M Y Wong Judy , FEBS J, 2013 Jul, Volume 280, Issue 14, p.3194-204, (2013) Severity of X-linked dyskeratosis congenita (DKCX) cellular defects is not directly related to dyskerin (DKC1) activity in ribosomal RNA biogenesis or mRNA translation., Thumati, Naresh R., Zeng Xi-Lei, Au Hilda H. T., Jang Christopher J., Jan Eric, and M Y Wong Judy , Hum Mutat, 2013 Dec, Volume 34, Issue 12, p.1698-707, (2013) Telomerase promotes efficient cell cycle kinetics and confers growth advantage to telomerase-negative transformed human cells., Fleisig, H B., and M Y Wong J , Oncogene, 2012 Feb 23, Volume 31, Issue 8, p.954-65, (2012) The accumulation and not the specific activity of telomerase ribonucleoprotein determines telomere maintenance deficiency in X-linked dyskeratosis congenita., Zeng, Xi-Lei, Thumati Naresh R., Fleisig Helen B., Hukezalie Kyle R., Savage Sharon A., Giri Neelam, Alter Blanche P., and M Y Wong Judy , Hum Mol Genet, 2012 Feb 15, Volume 21, Issue 4, p.721-9, (2012) Telomerase inhibition potentiates the effects of genotoxic agents in breast and colorectal cancer cells in a cell cycle-specific manner., Tamakawa, Raina A., Fleisig Helen B., and M Y Wong Judy , Cancer Res, 2010 Nov 1, Volume 70, Issue 21, p.8684-94, (2010)