Sindelar, Robert - University of British Columbia - Faculty of Pharmaceutical Sciences

个人简介

Dr. Robert Sindelar completed a MSc (1975) and a PhD (1980) in medicinal chemistry and natural products at the University of Iowa. Dr. Sindelar was previously chair and professor of Medicinal Chemistry at the University of Mississippi (1993-2000), as well as the interim dean of the School of Pharmacy and interim executive director of the Research Institute of Pharmaceutical Sciences at the University of Mississippi (2000–2001). Dr. Sindelar is currently professor and dean emeritus of the Faculty of Pharmaceutical Sciences at UBC. He is also vice president, Research & Academic Affairs at Providence Health Care, president of the PHC Research Institute, and associate dean, Research, at UBC's Faculty of Medicine. His teaching areas of interest include medicinal chemistry, drug discovery and design, and biotechnology as they impact pharmacy practice, patient outcomes and research.

研究领域

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Dr. Sindelar's research areas of interest include natural products isolation, design, synthesis and pharmacological evaluation of potential immunomodulators and agents to combat infectious diseases; rationally-designed enzyme inhibitors; computer-assisted molecular design and computational chemistry; protein homology modeling; and topographical modeling of structurally-rigid natural products and their possible use in immune modulation, microbial chemotherapy, cardiovascular disease, and chemotherapy. Current projects include the optimization of K-76 analogs as immunomodulators of the human complement cascade; and the design of potential inhibitors of human granzyme B.