研究领域

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Dr. Levine's studies involving clinical pharmacokinetics and drug metabolism are aimed at understanding the effects of drug interactions and genetic polymorphisms on drug therapy. Use of population pharmacokinetic data and Bayesian methods to optimize dosing are also investigated. Clinical research involves both observational studies and clinical trials to evaluate outcomes of drug therapy. Studies using large health databases are employed to address population-based questions of effectiveness and safety of drug therapy. Current projects include: Bayesian forecasting and vancomycin monitoring in premature neonates The use of population pharmacokinetic data to optimize vancomycin monitoring in these patients. Pharmacogenetics of codeine metabolism to morphine in Asian and Caucasian pediatric patients The development of genotyping methods for cytochrome P450 2D6*10 in Asian patients and investigating the effect of this allele on morphine production. Population-based comparison of two regimens for emergency contraception The use of population and clinical data from over 13,000 cases to compare the effectiveness of levonorgestrel and a combination of ethinyl estradiol and norgestrel when used for emergency contraception.