Hafeli, Urs - University of British Columbia - Faculty of Pharmaceutical Sciences

个人简介

Dr. Urs Hafeli completed a bachelor of science in pharmacy at the Federal Institute of Technology (Zurich, Switzerland) and a doctor of philosophy in pharmacy at Paul Scherrer Institute/Federal Institute of Technology in Zurich. Dr. Hafeli is an associate professor in the Faculty of Pharmaceutical Sciences at UBC. Dr. Hafeli enjoys teaching all aspects of drug delivery for both undergraduate (PHAR 220, PHAR 323) and graduate students (PHAR 592A, 510, 518, 525).

研究领域

Research in the Hafeli Laboratory is primarily directed at fighting cancer with radioactive pharmaceuticals and the development of diagnostic radiopharmaceuticals to be used in different nuclear medicine procedures. He also enjoys exploiting nanotechnology and microtechnology for different drug delivery applications, including the development of painless microneedles and the use of microfluidics for the preparation of monosized microspheres. Under the guidance of Research Associate Dr. Kathy Saatchi, the Hafeli laboratory has a strong chemistry base that encompasses organic, coordination and polymer chemistry. Using these tools, Dr. Hafeli’s research includes the entire spectrum of drug research from the synthesis and radiolabelling of new molecules; the preparation of drug delivery carriers such as nanoparticles, microspheres, antibodies, and polymers; the careful evaluation of drug delivery systems in vitro and in toxicology experiments; and finally, efficacy testing in different in vivo models using many different imaging modalities (SPECT, PET, CT, MRI, optical imaging). Current Projects Radiopharmaceuticals, the general name for radiolabelled diagnostic and therapeutic agents, can take many different shapes including particles sized from tens of nanometers (= nanospheres) up to about 100 micrometers (= microspheres), viscous solutions and micellar/liposomal suspensions, sheets, metal implants such as stents (metal or plastic coils), and biodegradable films. The Hafeli laboratory is interested in preparing radioactively labelled drug delivery vehicles of all shapes, made from many different materials, and using them to kill tumours and prevent their reoccurrence.

近期论文

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Electrospun magnetic nanofibre mats – A new bondable biomaterial using remotely activated magnetic heating, Zhong, Yi, Leung Victor, Wan Lynn Yuqin, Dutz Silvio, Ko Frank K., and Häfeli Urs O. , Journal of Magnetism and Magnetic Materials, Jan-04-2015, Volume 380, p.330 - 334, (2015) Simulation and experimental determination of the online separation of blood components with the help of microfluidic cascading spirals, Sprenger, Lisa, Dutz Silvio, Schneider Thomas, Odenbach Stefan, and Häfeli Urs O. , Biomicrofluidics, Jan-07-2015, Volume 9, Issue 4, p.044110, (2015) Utilization of nanoparticles as X-ray contrast agents for diagnostic imaging applications, é De La Vega, Carlos, and Häfeli Urs O. , Contrast Media & Molecular Imaging, Jan-03-2015, Volume 10, Issue 2, p.81 - 95, (2015) Lung Perfusion Imaging with Monosized Biodegradable Microspheres, Häfeli, Urs O., Saatchi Katayoun, Elischer Philipp, Misri Ripen, Bokharaei Mehrdad, Labiris ́e, and Stoeber Boris , Biomacromolecules, Aug-03-2010, Volume 11, Issue 3, p.561 - 567, (2010)