Coughtrie, Michael - University of British Columbia - Faculty of Pharmaceutical Sciences

个人简介

Dr. Michael Coughtrie is professor and dean at UBC's Faculty of Pharmaceutical Sciences. Born in Glasgow, Scotland, he received his BSc in biochemistry in 1983 and PhD in 1986 from the University of Dundee. Dr. Coughtrie also began his professional teaching and research career at the University of Dundee, based in the School of Medicine. In 2003, he was awarded a personal chair in biochemical pharmacology and became head of the Division of Pathology and Neuroscience. In 2008, he assumed the role of director, Division of Medical Sciences and in 2011 he accepted the appointment of operations director of the Medical Research Institute. Dr. Coughtrie commenced his term as dean of UBC Pharm Sci on August 1, 2013. His extensive teaching experience encompasses the development and implementation of a number of course modules in the fields of medicine, dentistry and science. As a researcher focusing on the roles of two major families of drug metabolizing enzymes, he has supervised numerous PhD and postdoctoral students, been invited to speak at over 70 international meetings and conferences, and has received more than 70 competitive research grants and contracts. In addition, Dean Coughtrie is an accomplished author, having written more than 170 papers, articles, book chapters, and abstracts appearing in publications such as The Biochemical Journal, The New England Journal of Medicine, The Journal of Biological Chemistry and Drug Metabolism & Disposition. Throughout his career, Dr. Coughtrie has volunteered his significant senior management experience and passion for pharmaceutical sciences to a number of different boards, committees and professional associations. He also serves on the editorial boards of publications including Pharmacogenetics & Genomics, Xenobiotica and Biomarkers.

研究领域

Dr. Coughtrie's research program is directed towards understanding the role of conjugation and transport in drug metabolism, and in the homeostasis of important endogenous compounds such as steroids, thyroid hormones and bilirubin. The main focus has been on the enzyme families sulfotransferases and UDP-glucuronosyltransferases, and he has carried out some of the seminal work that has guided our understanding of the role these enzymes play during human development. Another major interest is in the role that sulfation of glycosaminoglycans, which are important molecules that govern the interaction of cells with each other and their environment, plays in cancer.

近期论文

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Absolute immunoquantification of the expression of ABC transporters P-glycoprotein, breast cancer resistance protein and multidrug resistance-associated protein 2 in human liver and duodenum., Tucker, Theodora G. H. A., Milne Alison M., Fournel-Gigleux Sylvie, Fenner Katherine S., and Coughtrie Michael W. H. , Biochem Pharmacol, 2012 Jan 15, Volume 83, Issue 2, p.279-85, (2012) Epigenetics: methylation-associated repression of heparan sulfate 3-O-sulfotransferase gene expression contributes to the invasive phenotype of H-EMC-SS chondrosarcoma cells., Bui, Catherine, Ouzzine Mohamed, Talhaoui Ibtissam, Sharp Sheila, Prydz Kristian, Coughtrie Michael W. H., and Fournel-Gigleux Sylvie , FASEB J, 2010 Feb, Volume 24, Issue 2, p.436-50, (2010) Quantitative evaluation of the expression and activity of five major sulfotransferases (SULTs) in human tissues: the SULT "pie"., Riches, Zoe, Stanley Emma L., Bloomer Jackie C., and Coughtrie Michael W. H. , Drug Metab Dispos, 2009 Nov, Volume 37, Issue 11, p.2255-61, (2009) X-ray crystal structure of human dopamine sulfotransferase, SULT1A3. Molecular modeling and quantitative structure-activity relationship analysis demonstrate a molecular basis for sulfotransferase substrate specificity., Dajani, R, Cleasby A, Neu M, Wonacott A J., Jhoti H, Hood A M., Modi S, Hersey A, Taskinen J, Cooke R M., et al. , J Biol Chem, 1999 Dec 31, Volume 274, Issue 53, p.37862-8, (1999)