Abbott, Frank S - University of British Columbia - Faculty of Pharmaceutical Sciences

个人简介

Dr. Frank S. Abbott completed a bachelor of science in pharmacy (with great distinction) and master of science in medicinal chemistry at the University of Saskatchewan. He also holds a doctor of philosophy in medicinal chemistry from Purdue University.

研究领域

Dr. Abbott's research interests include analytical method development, drug receptor interactions, drug discovery, drug metabolism and drug interactions, as well as quantitative structure-activity-relationships-toxicological investigations of drugs and metabolites. Dr. Abbott's current research is focused on reactive metabolites and the production of reactive oxygen species as mechanisms of idiosyncratic drug toxicity. Please note Dr. Abbott is not supervising any new graduate students at this time.

近期论文

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Evaluation of In Situ Generated Valproyl 1-O- -Acyl Glucuronide in Valproic Acid Toxicity in Sandwich-Cultured Rat Hepatocytes, Surendradoss, J., Chang T. K. H., and Abbott F. S. , Drug Metabolism and Disposition, Jan-11-2014, Volume 42, Issue 11, p.1834 - 1842, (2014) A rapid and sensitive assay to quantify valproyl 1-O-acyl glucuronide in supernatants of sandwich-cultured rat hepatocytes using ultra-high performance liquid chromatography–tandem mass spectrometry, Surendradoss, Jayakumar, Szeitz ás, Teng Xiao Wei, Chang Thomas K. H., and Abbott Frank S. , Journal of Chromatography B, Jan-08-2013, Volume 932, p.40 - 49, (2013) Role of Oxidative Metabolism in the Effect of Valproic Acid on Markers of Cell Viability, Necrosis, and Oxidative Stress in Sandwich-Cultured Rat Hepatocytes, Kiang, T. K. L., Teng X. W., Karagiozov S., Surendradoss J., Chang T. K. H., and Abbott F. S. , Toxicological Sciences, Jan-12-2010, Volume 118, Issue 2, p.501 - 509, (2010) Oxidative stress in children receiving valproic acid, Michoulas, Aspasia, Tong Vincent, Teng Xiao Wei, Chang Thomas K. H., Abbott Frank S., and Farrell Kevin , The Journal of Pediatrics, Jan-11-2006, Volume 149, Issue 5, p.692 - 696, (2006) Oxidative Stress as a Mechanism of Valproic Acid-Associated Hepatotoxicity*, Chang, Thomas K. H., and Abbott Frank S. , Drug Metabolism Reviews, Jan-01-2006, Volume 38, Issue 4, p.627 - 639, (2006)