Devine, Dana - University of British Columbia - Department of Biochemistry and Molecular Biology

个人简介

Boston University, 1978, BA Biology Boston University, 1981, MA Biology Duke University, 1986, PhD Immunology

研究领域

The general subject areas of research expertise of this laboratory are platelet biology, complement biochemistry and blood coagulation. Our particular experimental focus in transfusion medicine is in the area of blood product processing and storage. Ongoing research projects include studies of the storage lesion of platelet concentrates and methods to improve the quality of stored platelet concentrates. Most recently, we have sought to apply leading edge technology to these research questions, in particular through the application of proteomics technology to investigations of blood products. The research in the laboratory also includes a significant component of applied development work with projects related to practical solutions to issues arising in the manufacture of blood products including process control and quality enhancement through modification of production processes or through understanding more about the significance of the variability of donor characteristics. We have ongoing collaborations with other scientists in all of these areas as well as collaborations with companies working in the blood transfusion business.

近期论文

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Serrano K, Chen D, Hansen AL, Levin E, Turner TR, Kurach JD, Acker JP, Devine DV. The effect of timing of gamma-irradiation on hemolysis and potassium release in leukoreduced red cell concentrates stored in SAGM. Vox Sang. 2013 Dec 12. Schubert P, Coupland D, Culibrk B, Goodrich RP, Devine DV. Riboflavin and ultraviolet light treatment of platelets triggers p38MAPK signaling: inhibition significantly improves in vitro platelet quality after pathogen reduction treatment. Transfusion. 2013 Dec;53(12):3164-73. Levin E, Serrano K, Devine DV; Biomedical Excellence for Safer Transfusion (BEST) Collaborative. Standardization of CD62P measurement: results of an international comparative study. Vox Sang. 2013 Jul;105(1):38-46. Williamson LM, Devine DV. Challenges in the management of the blood supply. Lancet. 2013 May 25;381(9880):1866-75. Schubert P, Coupland D, Culibrk B, Goodrich RP, Devine DV. Riboflavin and ultraviolet light treatment of platelets triggers p38MAPK signaling: inhibition significantly improves in vitro platelet quality after pathogen reduction treatment. Transfusion. 2013 Mar 22. doi: 10.1111/trf.12173. Reesink HW, Davis K, Wong J, Schwartz DW, Mayr WR, Devine DV, Georgsen J, Chiaroni J, Ferrera V, Roubinet F, Lin CK, O’Donovan B, Fitzgerald JM, Raspollini E, Villa S, Rebulla P, Makino S, Gounder D, Säfwenberg J, Murphy MF, Staves J, Milkins C, Mercado TC, Illoh OC, Panzer S. The use of the electronic (computer) cross-match. Vox Sang. 2013 May;104(4):350-64. Levin E, Serrano K, Devine DV; Biomedical Excellence for Safer Transfusion (BEST) Collaborative. Standardization of CD62P measurement: results of an international comparative study. Vox Sang. 2013 Jul;105(1):38-46. Schubert P, Culibrk B, Karwal S, Slichter SJ, Devine DV. Optimization of platelet concentrate quality: Application of proteomic technologies to donor management. J Proteomics. 2012 Dec;76 Spec No.:329-36. Semple E, Bowes-Schmidt A, Yi QL, Shimla S, Devine DV. Transfusion reactions: a comparative observational study of blood components produced before and after implementation of semiautomated production from whole blood. Transfusion. 2012 Dec;52(12):2683-91. Culibrk B, Stone E, Levin E, Weiss S, Serrano K, Devine DV. Application of the ADVIA cerebrospinal fluid assay to count residual red blood cells in blood components. Vox Sang. 2012 Oct;103(3):186-93. Devine DV, Serrano K. Preparation of blood products for transfusion: Is there a best method? Biologicals. 2012 May;40(3):187-90. Levin E, Jenkins C, Culibrk B, Gyöngyössy-Issa MI, Serrano K, Devine DV. Development of a quality monitoring program for platelet components: a report of the first four years’ experience at Canadian Blood Services. Transfusion. 2011 Nov 7. doi: 10.1111/j.1537-2995.2011.03402.x. [Epub ahead of print] Benjamin RJ, Bianco C, Goldman M, Seed CR, Yang H, Lee J, Keller AJ, Wendel S, Biagini S, Murray J, Devine DV, et al. Deferral of males who had sex with other males. Vox Sang. 2011 Nov;101(4):339-67. doi: 10.1111/j.1423-0410.2011.01489.x. Schubert P, Culibrk B, Coupland D, Scammell K, Gyongyossy-Issa M, Devine DV. Riboflavin and ultraviolet light treatment potentiates vasodilator-stimulated phosphoprotein Ser-239 phosphorylation in platelet concentrates during storage. Transfusion. 2012 Feb;52(2):397-408. Jenkins C, Ramírez-Arcos S, Goldman M, Devine DV. Bacterial contamination in platelets: incremental improvements drive down but do not eliminate risk. Transfusion. 2011 Dec;51(12):2555-65. Schubert P, Culibrk B, Coupland D, Levin E, Devine DV. Impact of sample volume and handling time during analysis on the in vitro quality measurements of platelet concentrates held in syringes. Int J Lab Hematol. 2011 Dec;33(6):579-85. van der Meer PF, Cancelas JA, Cardigan R, Devine DV, Gulliksson H, Sparrow RL, Vassallo RR, de Wildt-Eggen J, Baumann-Baretti B, Hess JR; BEST Collaborative. Evaluation of overnight hold of whole blood at room temperature before component processing: effect of red blood cell (RBC) additive solutions on in vitro RBC measures. Transfusion. 2011 Jan;51 Suppl 1:15S-24S. Schubert P, Devine DV. Proteomics meets blood banking: Identification of targets for the improvement of platelet quality. Journal of Proteomics 73: 436-44 (2010). Han V, Serrano K, Devine DV. A comparative study of common methods used to measure hemolysis in stored red cell concentrates. Vox Sanguinus (2010) e-pub ahead of print (PMID: 19719459). Serrano K, Scammell K, Weiss S, Culibrk B, Levin E, Gyongyossy-Issa M, Devine DV. Plasma and cryoprecipitate from whole blood held overnight at room temperature meet quality standards. Transfusion (2010) in press (doi: 10.1111/j.1537-2995.2009.02441.x). Hess JR, Sparrow RL, van der Meer PF, Acker JP, Cardigan RA, Devine DV. Red cell hemolysis during blood bag storage: Using national quality management data to answer basic scientific questions. Transfusion 49: 2599-603 (2009).