个人简介

B.A., Cornell University Ph.D., Yale University

研究领域

Drosophila developmental genetics

In the Verheyen lab we use molecular, genetic and biochemical approaches to understand organismal growth and patterning. Specifically, we are interested in how cells control their growth and how certain tissues regulate their pattern formation. To do this, we use Drosophila melanogaster, the fruit fly, as a genetic model organism. Our studies of Drosophila development allow us to ask questions about how cells respond to cues from neighboring cells. We have focused our efforts on two protein kinases that regulate cellular processes. These kinases, Nemo/Nlk and Hipk, both act during many stages of development and are essential for organismal survival. They exert their effect through regulation of key evolutionarily conserved signal transduction pathways, including those implicated in causing cancer when improperly regulated. Our goal is to gain an understanding of the mechanisms used by cells to ensure properly regulated growth and tissue formation.

近期论文

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Hall, E.T. and E.M. Verheyen (2015) Ras-activated Dsor1 promotes Wnt signaling in Drosophila development (CIHR) Journal of Cell Science, 128: 4499-4511. Pradhan-Sundd, T. and E.M. Verheyen (2015) The Myopic-Ubpy-Hrs nexus enables endosomal recycling of Frizzled. Molecular Biology of the Cell, 26:3329-3342. Fernandes, V.M., Pradhan-Sundd, T., Blaquiere, J. and E.M. Verheyen (2015) Ras/MEK/MAPK-mediated regulation of heparin sulfate proteoglycans promotes retinal fate in the Drosophila eye-antennal disc. Developmental Biology, 402: 109-118. Featured on the cover. Swarup, S., Pradhan-Sundd, T. and E.M. Verheyen (2015) Genome-wide in vivo identification of kinases and phosphatases that regulate Wnt signaling.Development,142 :1502-1515.