Unrau, Peter - Simon Fraser University - Department of Molecular Biology and Biochemistry

个人简介

B.Sc., McMaster University Ph.D., M.I.T. Peter Unrau’s education includes a B.Sc. in Physics and Mathematics from McMaster University (1992) and a Ph.D. in Theoretical Physics from MIT (1996). Following his graduation from MIT, Peter became interested in the emerging field of RNA catalysis and decided to join David Bartel’s laboratory as a postdoctoral fellow at the Whitehead Institute for Biomedical Research. His work there, which includes isolating the first RNA nucleotide synthase ribozyme, has been cited numerous times in the literature as a highly significant contribution to the RNA catalysis field. In 2001, Peter joined the faculty at Simon Fraser University where, with the help of his bright and energetic lab members, he runs an active research program in the area of RNA catalysis. He is currently Professor in the Department of Molecular Biology and Biochemistry at Simon Fraser University, a Michael Smith Foundation Senior Scholar, and a member of the Faculty of 1000.

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Dolgosheina EV, Jeng SC, Panchapakesan SS, Cojocaru R, Chen PS, Wilson PD, Hawkins N, Wiggins PA, Unrau PJ, RNA Mango Aptamer-Fluorophore: A Bright, High-Affinity Complex for RNA Labeling and Tracking. ACS Chem Biol (2014) [PDF] S. Menon, N. Vishnu, S.S.S. Panchapakesan, A.S. Kumar, K. Sankaran, P. Unrau, and M.A. Parameswaran, Electrochemical Sensing Methodology for Antibiogram Assays Chemical and Biological Sensors. J. Electrochemical Society (2014) [PDF] M. Oviedo Ovando, L. Shephard, P.J. Unrau, In vitro characterization of 6S RNA release-defective mutants uncovers features of pRNA-dependent release from RNA polymerase in E. coli. RNA (2014) [PDF] S.S.S. Panchapakesan and P.J. Unrau, E. coli 6S RNA release from RNA polymerase requires s70 ejection by scrunching and is orchestrated by a conserved RNA hairpin. RNA (2012) [PDF] Q.S. Wang, L.K.L. Cheng and P.J. Unrau, Characterization of the B6.61 polymerase ribozyme accessory domain. RNA (2011) [PDF] L.K.L Cheng and P.J. Unrau, Closing the Circle: Replicating RNA with RNA. (2010) Chapter in The Origins of Life, p229-244. D. Deamer & J. Szostak. eds. Cold Spring Harbor Press. Q. Wang and P.J. Unrau, Evolving an Understanding of RNA Function by In Vitro Approaches. (2010), Chapter in The Chemical Biology of Nucleic Acids, p355-376. G. Mayer ed, Wiley Press. L. Shephard, N. Dobson and P.J. Unrau. Binding and release of the 6S transcriptional control RNA. RNA (2010), 16(5):885-892 [PDF] M. Lau and P.J. Unrau. A Promiscuous Ribozyme Promotes Nucleotide Synthesis in Addition to Ribose Chemistry. Chemistry & Biology (2009), 16:815-825 [PDF] R. Salari, C. Aksay, E. Karakoc, P.J. Unrau, I. Hajirasouliha and S.C. Sahinalp. smyRNA: A Novel Ab Initio ncRNA Gene Finder. PLoS ONE (2009), 4(5), e5433 H.A. Ebhardt and P.J. Unrau. Characterizing multiple exogenous and endogenous small RNA populations in parallel with subfemtomolar sensitivity using a streptavidin gel-shift assay. RNA (2009), 15(4), 724-31 [PDF] L. Wang, N.A. Smith, L. Zhang, E.S. Dennis, P.M. Waterhouse, P.J. Unrau and M.B. Wang. Synthesis of complementary RNA by RNA-dependent RNA polymerases in plant extracts is independent of an RNA primer. Functional Plant Biology (2008) 35(11), 1091-99 E. Dolgosheina, R.D. Morin, G. Aksay, S.C. Sahinalp, V. Magrini, E.R. Mardis, J. Mattsson and P.J. Unrau. Conifers have a unique small RNA silencing signature. RNA (2008), 14(8), 1-8 [PDF] COVER ISSUE! R.D. Morin, G. Aksay, E. Dolgosheina, H.A. Ebhardt, V. Magrini, E.R. Mardis, S.C. Sahinalp and P.J. Unrau. Comparative analysis of the small RNA transcriptomes of Pinus contorta and Oryza sativa. Genome Research (2008), 18(4), 571-84 [PDF][dataset] 2007 & 2006 H.S. Zaher and P.J. Unrau. Selection of an improved RNA polymerase ribozyme with superior extension and fidelity. RNA (2007), 13(7), 1017-1026 [PDF] H.S. Zaher and P.J. Unrau. A General RNA-Capping Ribozyme Retains Stereochemistry during Cap Exchange. J. Am. Chem. Soc. (2006), 128(42), 13894-900 [PDF]. H.S. Zaher, R.A. Watkins and P.J. Unrau. Two independently selected capping ribozymes share similar substrate requirements. RNA (2006) 12(11), 1949-58 [PDF]. H.A. Ebhardt, K.C. Wiese and P.J. Unrau. Ebbie: automated analysis and storage of small RNA cloning data using a dynamic web server. BMC Bioinformatics (2006), 7:185 [PDF] H.A. Ebhardt, E.P. Thi, M.B. Wang, P.J. Unrau. Extensive 3' modification of plant small RNAs is modulated by helper component-proteinase expression. PNAS (2005) Sept 12 [PDF]. N. Lehman and P.J. Unrau. Recombination During In Vitro Evolution. J Mol Evol. (2005) 61(2), 245-52. [PDF]

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