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个人简介

A.A. (Theology), Golden Valley Lutheran College B.Sc. (Biology), Syracuse University B.Sc. (Chemistry), University of Minnesota Ph.D. (Chemistry), Ohio State University

研究领域

Protein Chemistry and Crystallography

Our lab uses molecular biology, protein chemistry, X-ray crystallography and other physical methods to investigate the structure and catalytic mechanism of enzymes. Currently we have many project related to viral protease self-processing, compartmentalized proteases, and eukaryotic membrane bound proteases.

近期论文

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Zhang et. al. Structural Characterization of the C3 Domain of Cardiac Myosin Binding Protein-C and its Hypertrophic Cardiomyopathy-Related R502W Mutant. Biochemistry 2014 Nam & Paetzel. Structure of signal peptide peptidase A with C-termini bound in the active sites: insights into specificity, self-processing and regulation. Biochemistry 2013 Chung & Paetzel. Crystal structure of Yellowtail ascites virus VP4 protease: trapping an internal cleavage site trans acyl-enzyme complex in a native Ser/Lys dyad active site. J Biol Chem 2013

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