个人简介

B.Sc., Biochemistry (honours), Bristol University M.Sc., Genetics, Simon Fraser University Ph.D., Bioinformatics, Sanger Institute, Cambridge

研究领域

Bioinformatics, Genomics

Dr Jones studies the genomic changes that accrue during the development of cancer. His work links mutational events with the molecular drivers of cancer. The goal is not only to determine more fully the molecular biology of oncogensis but to explore the potential drug senstivities associated with a cancer genotype. Dr Jones uses high-throughput DNA sequencing data from both the cancer genome and transcriptoome as well as epigenomic data as a substrate for his bioinformatic research.

近期论文

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Lian EY, Maritan SM, Cockburn JG, Kasaian K, Crupi MJ, Hurlbut D, Jones SJ, Wiseman SM, Mulligan LM. Differential roles of RET isoforms in medullary and papillary thyroid carcinomas. Endocr Relat Cancer. 2017 Jan;24(1):53-69. PMID: 27872141 Cancer Genome Atlas Research Network (346 collaborators) including Jones SJ, Integrated genomic characterization of oesophageal carcinoma. Nature. 2017 Jan 12; 541(7636):169-175. doi: 10.1038/nature20805. PMID: 28052061 Sheffield BS, Tessier-Cloutier B, Li-Chang H, Shen Y, Pleasance E, Kasaian K, Li Y, Jones SJ, Lim HJ, Renouf DJ, Huntsman DG, Yip S, Laskin J, Marra M, Schaeffer DF. Personalized oncogenomics in the management of gastrointestinal carcinomas-early experiences from a pilot study. Curr Oncol. 2016 Dec; 23(6):e571-e575. doi: 10.3747/co.23.3165. PMID: 28050146 Chan CK, Pan Y, Nyberg K, Marra MA, Lim EL, Jones SJ, Maar D, Gibb EA, Gunaratne PH, Robertson AG, Rowat AC. Tumour-suppressor microRNAs regulate ovarian cancer cell physical properties and invasive behaviour. Open Biol. 2016 Nov;6(11). pii: 160275. PMID: 27906134 International Human Epigenome Consortium (228 Collaborators) including Jones SJ. The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery. Cell. 2016 Nov 17;167(5):1145-1149. doi: 10.1016/j.cell.2016.11.007.PMID:27863232 Pellacani D, Bilenky M, Kannan N, Heravi-Moussavi A, Knapp DJ, Gakkhar S, Moksa M, Carles A, Moore R, Mungall AJ, Marra MA, Jones SJ, Aparicio S, Hirst M, Eaves CJ. Analysis of Normal Human Mammary Epigenomes Reveals Cell-Specific Active Enhancer States and Associated Transcription Factor Networks. Cell Rep. 2016 Nov 15;17(8):2060-2074. doi: 10.1016/j.celrep.2016.10.058. PMID: 27851968 Feau N, Taylor G, Dale AL, Dhillon B, Bilodeau GJ, Birol I, Jones SJ, Hamelin RC. Genome sequences of six Phytophthora species threatening forest ecosystems. Genom Data. 2016 Oct 3;10:85-88. PMID: 27752469 Lever, Jake, and Steven JM Jones. "VERSE: Event and Relation Extraction in the BioNLP 2016 Shared Task." ACL 2016 Aug 13, (2016): 42. Coombe L, Warren RL, Jackman SD, Yang C, Vandervalk BP, Moore RA, Pleasance S, Coope RJ, Bohlmann J, Holt RA, Jones SJ, Birol I. Assembly of the Complete Sitka Spruce Chloroplast Genome Using 10X Genomics' GemCode Sequencing Data. PLoS One. 2016 Sep 15;11(9):e0163059. doi: 10.1371/journal.pone.0163059. eCollection 2016. PMID: 27632164 Sheffield BS, Fulton R, Kalloger SE, Milne K, Geller G, Jones M, Jacquemont C, Zachara S, Zhao E, Pleasance E, Laskin J, Jones SJ, Marra MA, Yip S, Nelson BH, Gown AM, Ho C, Ionescu DN. Investigation of PD-L1 Biomarker Testing Methods for PD-1 Axis Inhibition in Non-squamous Non-small Cell Lung Cancer. J Histochem Cytochem. 2016 Sep 2. pii: 0022155416665338. [Epub ahead of print] PMID: 27591097 Grinshtein N, Rioseco CC, Marcellus R, Uehling D, Aman A, Lun X, Muto O, Podmore L, Lever J, Shen Y, Blough MD, Cairncross GJ, Robbins SM, Jones SJ, Marra MA, Al-Awar R, Senger DL, Kaplan DR. Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells.Oncotarget. 2016 Jul 18. doi: 10.18632/oncotarget.10661. [Epub ahead of print] PMID: 27449082 Younesy H, Nielsen CB, Lorincz MC, Jones SJ, Karimi MM, Möller T. ChAsE: chromatin analysis and exploration tool. Bioinformatics. 2016 Jul 4. pii: btw382. [Epub ahead of print] PMID: 27378294 Jones MR, Schrader KA, Shen Y, Pleasance E, Ch'ng C, Dar N, Yip S, Renouf DJ, Schein JE, Mungall AJ, Zhao Y, Moore R, Ma Y, Sheffield BS, Ng T, Jones SJ, Marra MA, Laskin J, Lim HJ. Response to angiotensin blockade with irbesartan in a patient with metastatic colorectal cancer. Ann Oncol. 2016 May;27(5):801-6. doi: 10.1093/annonc/mdw060. Epub 2016 Feb 18. PMID: 27022066 Miller RR, Langille MG, Montoya V, Crisan A, Stefanovic A, Martin I, Hoang L, Patrick DM, Romney M, Tyrrell G, Jones SJ, Brinkman FS, Tang P. Genomic Analysis of a Serotype 5 Streptococcus pneumoniae Outbreak in British Columbia, Canada, 2005-2009. Can J Infect Dis Med Microbiol. 2016;2016:5381871. doi: 10.1155/2016/5381871. Epub 2016 Apr 14. PMID: 27366170 de Leeuw CN, Korecki AJ, Berry GE, Hickmott JW, Lam SL, Lengyell TC, Bonaguro RJ, Borretta LJ, Chopra V, Chou AY, D'Souza CA, Kaspieva O, Laprise S, McInerny SC, Portales-Casamar E, Swanson-Newman MI, Wong K, Yang GS, Zhou M,Jones SJ, Holt RA, Asokan A, Goldowitz D, Wasserman WW, Simpson EM. rAAV-compatible MiniPromoters for restricted expression in the brain and eye. Mol Brain. 2016 May 10;9(1):52. doi: 10.1186/s13041-016-0232-4. PMID: 27164903 Kasaian K, Wiseman SM, Walker BA, Schein JE, Hirst M, Moore RA, Mungall AJ, Marra MA, Jones SJ. Putative BRAF activating fusion in a medullary thyroid cancer. Cold Spring Harb Mol Case Stud. 2016 Mar;2(2):a000729. doi: 10.1101/mcs.a000729.PMID: 27148585 Craig DW, Nasser S, Corbett R, Chan SK, Murray L, Legendre C, Tembe W, Adkins J, Kim N, Wong S, Baker A, Enriquez D, Pond S, Pleasance E, Mungall AJ, Moore RA, McDaniel T, Ma Y, Jones SJ, Marra MA, Carpten JD, Liang WS. A somatic reference standard for cancer genome sequencing. Sci Rep. 2016 Apr 20;6:24607. doi: 10.1038/srep24607. PMID: 27094764 Lien S, Koop BF, Sandve SR, Miller JR, Kent MP, Nome T, Hvidsten TR, Leong JS, Minkley DR, Zimin A, Grammes F, Grove H, Gjuvsland A, Walenz B, Hermansen RA, von Schalburg K, Rondeau EB, Di Genova A, Samy JK, Olav Vik J, Vigeland MD, Caler L, Grimholt U, Jentoft S, Inge Våge D, de Jong P, Moen T, Baranski M, Palti Y, Smith DR, Yorke JA, Nederbragt AJ, Tooming-Klunderud A, Jakobsen KS, Jiang X, Fan D, Hu Y, Liberles DA, Vidal R, Iturra P, Jones SJ, Jonassen I, Maass A, Omholt SW, Davidson WS. The Atlantic salmon genome provides insights into rediploidization. Nature. 2016 Apr 18. doi: 10.1038/nature17164. [Epub ahead of print] PMID: 27088604 Pan Y, Robertson AG, Pedersen L, Lim E, Hernandez-Herrera A, Rowat A, Chan C, Wen Y, Zhang X, Patil S, Basu-Roy U, Mansukhani A, Chu A, Sipahimalani P, Bowlby R, Brooks D, Thiessen N, Ma Y, Moore R, Schein J, Mungall A, Pecot C, Sood A, Jones S, Marra M, Gunaratne P. miR-509-3p is clinically significant and strongly attenuates cellular migration and multi-cellular spheroids in ovarian cancer. Oncotarget. 2016 Mar 27. doi: 10.18632/oncotarget.8412. PMID:27036018 Chun H-Y, Lim EL, Heravi Moussavi A, Saberi S, Mungall KL, Bilenky M, Carles A, Tse K, Shlafman I, Zhu K, Qian JQ, Harvey D, He A, Long W, Goya R, Ng M, LeBlanc VG, Pleasance E, Thiessen N, Wong T, Chuah E, Zhao YJ, Schein JE, Gerhard DS, Taylor MD, Mungall AJ, Moore RA, Ma Y, Jones SJM, Perlman EJ, Hirst M, Marra MA. Genome-wide profiles of extra-cranial malignant rhabdoid tumors reveal heterogeneity and dysregulated developmental pathways. Cancer Cell. 2016 Mar 14;29(3):394-406. PMID: 26977886