Linhardt, Robert J. - Rensselaer Polytechnic Institute - Department of Chemistry & Chemical Biology

个人简介

Education 1979-82 Post Doc in Biochemical Engineering and Bioorganic Chemistry in the Langer Lab, MIT, Cambridge, MA 1979 Organic Chemistry Ph.D. from The Johns Hopkins University, Baltimore. MD 1977 Organic Chemistry M.A. from The Johns Hopkins University, Baltimore. MD 1975 Chemistry B.S. from Marquett University, Milwaukee, WI Biography After 21 years on the faculty of the University of Iowa, Linhardt joined Rensselaer in 2003 as a senior constellation professor. Since 2008 Dr. Linhardt's group has been working on a collaboration to bioengineer Heparin from E. coli. During his career in Iowa, he spent eight years as the university’s F. Wendell Miller Distinguished Professor of Chemistry and ten years as a member of the Executive Committee of the Center for Biocatalysis and Bioprocessing. Linhardt began his professional career with a three-year postdoctorate in chemical engineering at Massachusetts Institute of Technology.

研究领域

Bioengineering and Metabolic Engineering Biomolecular Interaction and The Interactome Carbohydrate Analysis and Structural Biology Glycobiology and Glycomics NanoBiotechnology and Nano-scale and Micron-scale Devices Synthetic Carbohydrate Chemistry

近期论文

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"Structural characterization and anti-lung cancer activity of a sulfated glucurono-xylo-rhamnan from Enteromorpha prolifera," W. Jin, X. He, L. Long, Q. Fang, B. Wei, J. Sun, W. Zhang, H. Wang, F. Zhang, R. J. Linhardt, Carbohydrate Polymers, in press, 2020. "Chemical, enzymatic and biological synthesis of hyaluronic acids," J. Li, M. Qiao, Y. Ji, L. Lin, X. Zhang, R. J. Linhardt, International Journal of Biological Macromolecules, in press, 2020. "Loss and rescue of osteocalcin and osteopontin modulate osteogenic and angiogenic features of mesenchymal stem/stromal cells," M. S. Carvalho, J. C. Silva, C. Hoff, J.M. S. Cabral, R. J. Linhardt, C. Lobato da Silva, D. Vashishth, Journal of Cellular Physiology, in press, 2020. "Molecular mechanisms of bioactive polysaccharides from Ganoderma lucidum (Lingzhi), a review," J. Lu, R. He, P. Sun, F. Zhang, R. J. Linhardt, A. Zhang, International Journal of Biological Macromolecules, in press, 2020. "Autophagic degradation of HAS2 in endothelial cells: A novel mechanism to regulate angiogenesis," C. G. Chen, M. A. Gubbiotti, X. Han, Y. Yu, R. J. Linhardt, R. V. Iozzo, Matrix Biology in press, 2019. "Chondrogenic differentiation of mesenchymal stem/stromal cells on 3D porous poly (ε-caprolactone) scaffolds: effects of material alkaline treatment and chondroitin sulfate supplementation," C. S. Moura, J. C. Silva, S. Faria, P. R.Fernandes, J. M. S. Cabral, R. J. Linhardt, P. J. Bártolo, F. C. Ferreira, Journal of Bioscience and Bioengineering, in press, 2020. "Non-anticoagulant heparin as a pre-exposure prophylaxis prevents Lyme disease infection," Y.-P. Lin, , Y. Yu, A. Marcinkiewicz, P. Lederman, T. Hart, F. Zhang, R. J. Linhardt, ACS Infectious Diseases, in press, 2020. "Comprehensive glycomic analysis reveals that human serum albumin glycation specifically affects the pharmacokinetics and efficacy of different anticoagulant drugs in diabetes," H. Qiu, L. Jin, J. Chen, M. Shi, F. Shi, M. Wang, D. Li, X. Xu, X. Su, X. Yin, W. Li, X. Zhou, R. J. Linhardt, Z. Wang, L.Chi, Q. Zhang, Diabetes, in press, 2020. "Effects of glycosaminoglycan supplementation in the chondrogenic differentiation of bone marrow- and synovial- derived mesenchymal stem/stromal cells on 3D-extruded poly (ε-caprolactone) scaffolds," J C. Silva, C. S. Moura, G. Borrecho, A. P. Alves de Matos, Joaquim M. S. Cabral, R. J. Linhardt, F. C. Ferreira, International Journal of Polymeric Materials and Polymeric Biomaterials, in press, 2019. "Extraction, structure and bioactivities of the polysaccharides from Pleurotus eryngii: A Review," B. Zhang, Y. Li, F. Zhang, R. J. Linhardt, G. Zeng, A. Zhang, International Journal of Biological Macromolecules, in press, 2019. "A novel laminin-binding protein mediates microbial-endothelial cell interactions and facilitates dissemination of Lyme disease pathogens," S. Bista, P. Singh, Q. Bernard, X. Yang, T. Hart, Y.-P. Lin, C. Kitsou, V. S. Rana, F. Zhang, R. J. Linhardt, K. Zhang, D. R. Akins, L. Hritzo, Y. Kim, D. J. Grab, J. S. Dumler, U. Pal, Journal of Infectious Diseases, in press, 2019. "Glycosaminoglycan disaccharide compositional analysis of cell-derived extracellular matrices using liquid chromatography-tandem mass spectrometry," J. C. Silva, M. S. Carvalho, K. Xia, J. M. S. Cabral, C. L. da Silva, F. C. Ferreira, D. Vashishth, R. J. Linhardt, In Methods in Cell Biology, Volume 156, Cell-derived Matrices, Part A, Elsevier, in press, 2019. "Enzymatic Bioconversion of Cycloastragenol-6-O-β-D-glucoside into Cycloastragenol by a Novel Recombinant β-Glucosidase from Phycicoccus sp. Soil748," L. Cheng, H. Zhang, H. Liang, X. Sun, X. Shen, J. Wang, W. Wang, Q. Yuan, H.-I. Ri, T.-M. Kim, M.-S. Kang, R. J. Linhardt, Process Biochemistry, in press, 2019. "Fermented cassava residue lignin prepared by sequential acid steam-explosion and hot-alkaline treatment and its antioxidant properties," W. Wang, S. Wanga, Y. Pana, X. Ouyang, R. J. Linhardt, Waste and Biomass Valorization, in press, 2019. "Structural analysis of urinary glycosaminoglycans from healthy human subjects," X. Han, P. Sanderson, S. Nesheiwat, L. Lin, Y. Yu, F. Zhang, I. J. Amster, R. J. Linhardt, Glycobiology, in press, 2019. "Encapsulation of phycocyanin by prebiotics and polysaccharides-based electrospun fibers and improved colon cancer prevention effects," Y. Wen, P. Wen, T.-G. Hu, R. J. Linhardt, M.-H. Zong , H. Wu, Z.-Y. Chen, International Journal of Biological Macromolecules 149, 672–681, 2020. LINK "Extraction Methods Affect the Structure and Bioactivity of Goji (Lycium barbarum) Polysaccharides," S. Zhou, R. Md Atikur, J. Li, D. Wu, C. Wei, J. Chen, R. J. Linhardt, X. Ye, Sh. Chen, Molecules, 25, 936, 2020. LINK "Chemoenzymatic Synthesis of Glycosaminoglycans," X. Zhang, L. Lin, H. Huang, R. J. Linhardt, Accounts of Chemical Research, 53, 335−346, 2020. LINK "Digestibility of squash polysaccharide under simulated salivary, gastric and intestinal conditions and its impact on short chain fatty acid production in type-2 diabetic rats," L. Liang, G. Liu, F. Zhang, Q. Li, R. J. Linhardt, Carbohydrate Polymers, 235, 115904, 2020. LINK "Mass spectrometric evidence for the mechanism of free-radical depolymerization of various types of glycosaminoglycans," N. Zhang, G. Li, S. Li, C. Cai, F. Zhang, R. J. Linhardt, Guangli Yu, Carbohydrate Polymers,233, 115847, 2020. LINK