个人简介

B. Sc. & M.Sc. - Shandong University Ph. D. - Peking University (Beijing) Postdoctoral Fellow - California Institute of Technology Postdoctoral Fellow - NRC Steacie Institute for Molecular Sciences

研究领域

Bioanalytical and Materials Chemistry

Bioanalytical Chemistry and Physical Chemistry The research work conducted in my group at Simon Fraser University spans a broad range of analytical, physical, and materials chemistry. In particular, we are interested in surface modification with self-assembled monolayers, fabrication/characterization of nanostructured materials, and development of biosensing devices. Active projects include: DNA surface chemistry and aptamer-based electronic biosensors. A thorough understanding of DNA surface chemistry is critical to the fabrication of DNA microarrays for high-throughput gene analysis and of aptamer (nucleic acid receptor)-based biosensors for ultrasensitive protein detection. We have developed an electrochemical method that is simple and versatile for quantifying DNA-modified surfaces, which also allowed detailed investigations of cation / DNA interactions on surface. We have been exploring chip-based methodologies for measuring the electrochemical signals induced in “deoxyribosensors” (rationally designed DNA conformational switches using aptamer sequences) upon analyte binding. These synthetic DNA-based biosensors have considerable commercial potential as replacement of animal-produced antibody probes for near-patient clinical testing. Disc-based bioanalytical and materials chemistry. We previously invented a method for using compact discs (CD) as inexpensive, high-quality gold substrates suitable for the preparation of self-assembled monolayers and fabrication of electrode microarrays. We also developed an efficient protocol to activate the plastic CD base as biochip substrate (e.g., microfluidic DNA microarrays), which leads to the success of reading disc-based bioassays with standard optical drives of ordinary laptop/desktop computers. In addition, our demonstration of “templated” electrodeposition of inorganic oxide thin films on micropatterned CD-R substrates is a prime example of innovation in research that has significant potential for practical applications. Molecular modification of semiconductors and electrical characterization. Our method of silicon surface modification with Si-C bonded monolayers and the systematic characterization by various analytical techniques has won us a leading position in this rapidly developing field. In particular, we took an important step of directly measuring the electrical properties of organic monolayers on silicon with a non-invasive Hg electrode, and observed molecular rectification behaviors.This work represents a new route toward functional nanoscale electronic devices. Since silicon as electrode material is compatible with existing microelectronic technologies, DNA biosensors may be fabricated in the same manner as computer chips in the future.

近期论文

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Metastable Molecular Metal-Semiconductor Junctions, Zhu, L.; Popoff, R. T. M.; Yu, H.-Z. J. Phys. Chem. C 2015, 119, in press (accepted Dec. 30, 2014). Indirect Competitive Assays on DVD for Direct Multiplex Detection of Drugs of Abuse in Oral Fluids, Zhang, L.; Li, X.; Li, Y.; Shi, X.; Yu, H.-Z. Anal. Chem. 2015, 87, in press (accepted Dec. 23, 2014). DNA mechatronic devices switched by K+ and by Sr2+ are structurally, topologically and electronically distinct, Huang, Y. C.; Yu, H.-Z.; Sen, D. Biopolymers 2015, 103, in press ( accepted Nov. 18, 2014). Unique intramolecular electronic communications in mono-ferrocenylpyrimidine derivatives: correlation between redox properties and structural nature, Xiang, D.; Noel, J.; Shao, H.; Dupas, G.; Merbouh, N.; Yu, H.-Z. Electrochimi. Acta 2015, in press (accepted Aug. 28, 2014). Comment on “Image-based ELISA on an activated polypropylene microtest plate - A spectrophotometer-free low cost assay technique” Wong, J. X.; Yu, H.-Z. Biosen. Bioelectron. 2015, 63, 602-604. Thin-film voltammetry and its analytical applications: A review, Tian, H.; Li, Y.; Shao, H.; Yu, H.-Z. Anal. Chim. Acta 2015, 855, 1-12 (Featured Review Article; cover picture). Mobile app-based quantitative scanometry, Wong, J. X. H.; Liu, F. S. F.; Yu, H.-Z. Anal. Chem. 2014, 86, 11966−11971. Synthesis and photo-sensing properties of Zn-ZnO core-shell nanofibers, Hsu, S.-H.; Chen, Y.-P.; Ye, C.-C.; Tseng, I.-L.; Chao, L.-C.; Yu, H.-Z. Sen. Actuators B 2014, 204,175–182. DNA molecular beacon-based plastic biochip: a versatile and sensitive scanometric detection platform, Shi, X.; Wen, J.; Zheng, Y.; Li, Y.; Zhou, J.; Li, X.; Yu, H.-Z. ACS Appl. Mater. Interface 2014, 6, 21788–21797. Electrochemical identification of molecular heterogeneity in binary redox self-assembled monolayers on gold, Tian, H.; Xiang, D.; Shao, H.; Yu, H.-Z. J. Phys. Chem. C 2014, 118, 13733–13742. DVD technology-based molecular diagnosis platform: quantitative pregnancy test on a disc, Li, X.; Weng, S.; Ge, B.; Yao, Z.; Yu, H.-Z., Lab Chip. 2014, 14, 1686–1694. DVD diagnostic software for reading disc-based bioassays, a comparative study, Zhao, X.; Li, X.; Cui, C.; Yu, H.-Z., Sen. Actuators B 2014, 195, 116–122. Functional DNA switches: rational design and electrochemical signaling, Tang, Y.; Ge, B.; Sen, D.; Yu, H.-Z., Chem. Soc. Rev. 2014, 43, 518–529. Selective dehybridization of DNA-Au nanoconjugates using laser irradiation, Asanuma, H.; Jiang, Z.; Ikeda, K.; Uosaki, K.; Yu, H.-Z. Phys. Chem. Chem. Phys. 2013, 15, 15995–16000. Preparation of transparent superhydrophobic glass slides: Demonstration of surface chemistry characteristics, Wong, J.X.; Yu, H.-Z., J. Chem. Ed. 2013, 90, 1203-1206. Facile fabrication of ZnO nanowire-based UV sensors by focused ion beam micromachining and thermal oxidation, Chao, L.-C.; Ye, C.-C.; Chen, Y.-P.; Yu, H.-Z., Appl. Surf. Sci. 2013, 282, 384–389. Controlled wetting on electrodeposited oxide thin films: from hydrophilic to superhydrophobic, Hao, Y.; Soolaman, D. M.; Yu, H.-Z., J. Phys. Chem. C 2013, 117, 7736–7743. Immobilization of redox-labeled hairpin DNA aptamers on gold: electrochemical quantitation of epithelial tumor marker mucin 1, Ma, F.; Ho, C.; Cheng, A. K. H.; Yu, H.-Z. Electrochimi. Acta 2013, 110, 139-145 (2012 ISE meeting special issue). Reading Disc-Based Bioassays with Standard Computer Drives, Yu, H.-Z.; Li, Y.; Ou, L.M.L. Acc. Chem. Resc. 2013, 46, 258–268. Simple and reproducible method of preparing transparent superhydrophobic glass, Wong, J.X.H.; Asanuma, H.; Yu, H.-Z. Thin Solid Films, 2012, 522, 159-163