个人简介

B.Sc. - University of Victoria Ph.D. - University of British Columbia Postdoctoral Fellow - Stanford University

研究领域

Medicinal Inorganic Chemistry and Catalysis

Medicinal Inorganic Chemistry and Catalysis Bioinorganic chemistry, neurodegenerative disease, Alzheimer’s, metal-based diagnostic and therapeutic agents, catalysis, bimetallic cooperativity, and electronic structure. Medicinal Inorganic Chemistry Medicinal inorganic chemistry can be divided into two main categories, (1) drugs that target metal ions in some form, and (2) metal-based drugs where the central metal ion is essential for the clinical application. Due to our increased understanding of biological processes and disease physiology, new opportunities exist for the design of metal-based and metal-binding agents. We are particularly interested in the application of medicinal inorganic chemistry to the diagnosis and therapy of neurodegenerative disorders, and cancer. The increased incidence of neurodegenerative disease such as Alzheimer’s, and the lack of effective treatment strategies, makes this a critical research area. We are focusing our studies on two hallmarks of the disease; amyloid-beta plaques and neurofibrillary tangles. We are also applying chemical tools to oncology to develop non-invasive imaging agents that show selective uptake in cancerous tissue. New cancer diagnostics are needed to increase our understanding of this disease, better assess treatment regimens, and develop innovative therapies. Working at the interface of inorganic chemistry, biology, and medicine, group members have the opportunity to collaborate across disciplines to investigate innovative treatment strategies. Catalysis We are interested in harnessing bimetallic cooperativity and ligand non-innocence to increase substrate affinity, and enhance redox reactivity and ensuing chemical transformations along multi-electron pathways. By integrating knowledge of metalloenzyme structure and function we aim to develop bioinspired catalysts capable of important organic transformations. Key to this work is characterizing the electronic structure of the synthesized transition metal complexes and determining how this relates to the observed physical properties and reactivity.

近期论文

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Leconte, N., Moutet, J., Herasymchuk, K., Clarke, R.M., Philouze, C, Luneau, D., Storr, T., Thomas, F., Mn(IV) and Mn(V)-radical Species Supported by the Redox Non-innocent bis(2-amino-3,5-di-tert-butylphenyl)amine Pincer Ligand. Chem. Commun., 2017, ASAP. DOI: 10.1039/C7CC00516D. 66. Miller, J.J., Gomes, L.M.F., Storr, T., Casini, A., The Interaction of Metal Compounds with Protein Targets: New Tools in Medicinal Chemistry and Chemical Biology. Encyclopedia of Inorganic and Bioinorganic Chemistry., Accepted, eibc.2499. 65. Dyrager, C., Pinto Vieira, R. P., Nyström, S., Nilsson, K. P., Storr, T. Synthesis and Evaluation of Benzothiazole-triazole and Benzothiadiazole-triazole Scaffolds as Potential Molecular Probes for Amyloid-β Aggregation. New. J. Chem., 2017, 41, 1566-1573. DOI: 10.1039/c6nj01703g 64. Garcia, C.V, Parrilha, G.L., Rodrigues, B.L., Barbeira, P.J.S., Clarke, R.M., Storr, T., Beraldo, H., Cobalt(III) Complexes with 2-Acetylpyridine-derived Schiff Bases: Studies Investigating Ligand Release Upon Reduction. Polyhedron, 2017, 124, 86. DOI: 10.106/j.poly.2016.12.024 63. Clarke, R.M., Storr, T., Tuning Electronic Structure to Control Manganese Nitride Activation. J. Am. Chem. Soc., 2016, 138, 15299-15302. DOI: 10.1021/jacs.6b09576 62. Lecarme, L., Chiang, L., Moutet, J., Leconte, N., Philouze, C., Jarjayes, O., Storr, T., Thomas, F., The Structure of a one-electron oxidized Mn(III)-bis(phenolate)dipyrrin Radical Complex and Oxidation Catalysis Control via Ligand-centered Redox Activity. Dalton Trans., 2016, 45, 16325-16334. DOI: 10.1039/C6DT02163H 61. Herasymchuk, K., Chiang, L., Hayes, C. E., Brown, M. L., Ovens, J. S., Patrick, B. O., Leznoff, D. B., Storr, T. Synthesis and Electronic Structure Determination of Uranium(VI) Ligand Radical Complexes. Dalton. Trans. 2016, 45, 12576-12586. DOI: 10.1039/C6DT02089E 60. Langille, G., Yang, H., Zeisler, S.K., Hoehr, C., Storr, T., Andreoiu, C., Schaffer, P. Low Energy Cyclotron Production and Cyclometalation Chemistry of Iridium-192. Appl. Rad. Isotopes 2016, 115, 81-86. DOI:10.1016/j.apradiso.2016.06.005 59. Jones, M. R., Dyrager, C., Hoarau, M., Korshavn, K. J., Lim, M. H., Ramamoorthy, A., Storr, T. Multifunctional Quinoline-Triazole Derivatives as Potential Modulators of Amyloid-β Peptide Aggregation. J. Inorg. Biochem., 2016, 158, 131-138. DOI:1016/j.jinorgbio.2016.04.022 58. Clarke, R.M., Hazin, K., Thompson, J.R., Savard, D., Prosser, K.E., and Storr, T. Electronic Structure Description of a Doubly Oxidized Bimetallic Cobalt Complex with Pro-Radical Ligands. Inorg. Chem., 2016, 55, 762-774. DOI: 10.1021/acs.inorgchem.5b02231 57. Chiang, L., Clarke, R.M., Herasymchuk, K., Sutherland, M., Prosser, K.E., Shimazaki, Y., and Storr, T. Electronic Structure Evaluation of an Oxidized Tris-Methoxy Ni Salen Complex. Eur. J. Inorg. Chem., 2016, 49-55. DOI: 10.1002/ejic.201501144 56. Storr, T., Thompson, J. R., Patrick, B. O., Reiff, W. O., Storr, A., Thompson, R. C. A Sheet Structured MOF Magnet: Poly[(1,10-phenanthroline)tetrakis(imidazolato)diiron(II)]. Polyhedron, 2016, 108, 80-86. DOI: 10.1016/j.poly.2015.08.022 . For the ‘Canadian issue’ 55. Chong, E., Xue, W., Storr, T., Kennepohl, P., Schafer, L. L. Synthesis of a 2-pyridonate titanium(III) complex using benzylamine as a simple reductant. Organometallics, 2015, 34, 4941-4945. 54. Chiang, L., Herasymchuk, K., Thomas, F., Storr, T. Influence of Electron-Withdrawing Substituents on the Electronic Structure of Oxidized Ni and Cu Salen Complexes. Inorg. Chem, 2015, 54, 5970-5980 DOI: 10.1021/acs.inorgchem.5b00783 53. Vieira, R. P., Thompson, J. R., Beraldo, H., Storr, T. Partial conversion of thioamide into nitrile in a copper(II) complex of 2,6 diacetylpyridine bis(thiosemicarbazone), a drug prototype for Alzheimer's Disease. Acta Cryst. C71, 2015, C71, 430-434, doi:10.1107/S205322961500813X 52. Jones, M. R., Mu, C., Wang, M. C. P., Webb, M. I., Walsby, C., Storr, T. Modulation of the Aβ peptide aggregation pathway by KP1019 limits Aβ-associated neurotoxicity. Metallomics, 2015, 7, 129-135. DOI: 10.1039/C4MT00252K . 51. Alaji, Z., Safaei, E., Chiang, L., Clarke, R. M., Mu., C., Storr, T., A new copper complex of a non-innocent iminophenol-amidopyridine hybrid ligand: synthesis, characterization, and aerobic alcohol oxidation. Eur. J. Inorg. Chem., 2014, 35, 6066-6074. DOI: 10.1002/ejic.201402687. 50. Kawai, M, Yamaguchi, T., Masaoka, S., Tani, F., Kohzuma, T., Chiang, L., Storr, T., Ogura, T., Szilagyi, R. K., Shimazaki, Y. Influence of ligand flexibility on the electronic structure of oxidized Ni(III)-phenolato complexes, Inorg. Chem. 2014, 53, 10195-10202. DOI: 10.1021/ic501181k. 49. Savard, D., Storr, T., Leznoff, D. Magnetostructural characterization of copper(II) hydroxide dimers and coordination polymers coordinated to apical isothiocyanate and cyanide-based counteranions. Can. J. Chem., 2014, 92, 1021-1030. DOI: 10.1139/cjc-2014-0186 48. Lecarme, L., Chiang, L., Philouze, C., Jarjayes, O., Storr, T., Thomas, F. Detailed geometric and electronic structures of a one-electron oxidized Ni salophen complex and its amido derivatives. Eur. J. Inorg. Chem., 2014, 3479-3487, DOI: 10.1002/ejic.201402265